Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2

... conformational states of protein under force 21 2. 2 Energy landscape of two state model 21 2. 3 Calculated force-extension curve of folded and unfolded i27 23 2. 4 Calculated ... transitions of protein 20 2. 1.1 2. 1 .2 Force-extension curves of the structural states 22 2. 1.3 Force dependent free energy diﬀerences between states 23 2. 1.4 2. 2 Structural states during two state ... elucidate the key players and underlying mechanosensing mechanisms (Reviewed in [38]) 1 .2. 2 integrin based cell- matrix adhesions Integrin based cell- matrix adhesions are the most-studied cell adhesions...

Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc

... neuronal death FEBS J Teixeiro E & Daniels MA (2009) ERK and cell death: ERK location and T cell selection FEBS J Martin P & Pognonec P (2009) ERK and cell death: cadmium toxicity, sustained ERK activation ... ERK- mediated cell death: sustained and sequestered activity ROS as mediators of ERK- induced cell death In the majority of the studies related to cell death induced by the Ras ⁄ Raf ⁄ ERK pathway, ERK ... 1773, 122 7–1 237 Balmanno K & Cook SJ (2009) Tumour cell survival signalling by the ERK1 ⁄ pathway Cell Death Differ 16, 36 8–3 77 Subramaniam S & Unsicker K (2009) ERK and cell death: ERK1 ⁄ in...

Báo cáo y học: "Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection" pdf

... this TAHIV cohort after 20 years of infection [7] Early studies on this cohort of TAHIV patients led to the identification of the Sydney Blood Bank Cohort (SBBC) of long-term survivors [8], and ... NSW, Australia, a cohort of 13 (10%) remained asymptomatic after 10 years of infection We now report that only remain non-progressors after 23 to 26 years of HIV- 1 Page of 14 (page number not for ... transitionary stage toward disease progression in C13 The p24 proliferative response was the single immune parameter that consistently defined control of viraemia and non -progression The p24 proliferative...

Báo cáo y học: " Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin c" ppsx

... Mechanism of CS-induced lung damage and prevention by vitamin C Figure Mechanism of CS-induced lung damage and prevention by vitamin C Mechanism of CS-induced lung damage and prevention by vitamin ... Figure and lung damage caused by intratracheal instillation of p-BSQ in guinea pigs and prevention by vitamin C Apoptosis Apoptosis and lung damage caused by intratracheal instillation of p-BSQ ... days CS+vit C 15mg Figure large dosage of of lung C Histopathology vitamin sections of guinea pigs exposed to CS showing progressive lung damage and prevention by moderately Histopathology of lung...

Báo cáo y học: "Lung epithelium as a sentinel and effector system in pneumonia – molecular mechanisms of pathogen " pdf

... resistant bacteria, and the emergence of new pulmonary pathogens into account, an exact analysis of molecular mechanisms of disease is mandatory to form a rational basis for the development of innovative ... pulmonary innate immune system A large variety of pathogens are known to cause pneumonia The innate immune system serves as the first line host defense system against invading pathogens Localized at ... pathways, including e.g tyrosine kinases [197] or protein kinase C [198], may also play an important role, but have not been analyzed yet in detail in pulmonary epithelium Importantly, most investigations...

Dendritic cells respond differently to live and killed bacteria molecular mechanisms of pathogen recognition by dendritic cells and implications for vaccine development

... B and T cells leading to proliferation and the generation of antibodies (for B cells) and the generation of armed effector T cells such as cytotoxic T cells and helper T cells (Th) (for T cells) ... responses to live and killed bacteria may also provide important insights into the molecular mechanisms of how DC senses microbial pathogens These may help in targeting of vaccines to DCs for specific ... response of DC to live and killed E.coli Heat -killed E.coli was indistinguishable from live and UV -killed bacteria in promoting DC expression of MHC II, CD40, CD54, CD83, CD80 and CD86 With respect to...

Investigating the molecular mechanism of ERp29 regulated cell cycle arrest in breast cancer

... nodes behind the breastbone Or Inflammatory breast cancer is a rare type of breast cancer The breast looks red and swollen because cancer cells block the lymph vessels in the skin of the breast ... dissertation, the author attempt to investigate how ERp29 may regulate another effector of PERK, Nrf2 in breast cancer cell lines The levels of eIFα and Nrf2 in a panel of breast cancer cell lines including ... malignant cancer that originates from breast cells Breast cancer mostly originates in the cells of lobules or ducts Cancers originating from ducts are known as ductal carcinomas; those originating...

A study on pronunciation errors made by fourth year students of english at vinh university and suggested solutions

... Findings and Discussion on Pronunciation Errors made by fourth year students of English First and foremost, the data helps to reveal the vowel and consonant sounds errors that fourth year students of ... such as "English Pronunciation Made Simple" and English Phonetics and Phonology” Hence, these subjects have basic ideas of pronunciation rules and certain awareness of their own pronunciation ... Hence, pronunciation of English 20 varies from place to place, and therefore, a standard pronunciation in one place may not be as much standard in others It seems that the goal Standard English has...

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Báo cáo khoa học: Molecular mechanisms of the phospho-dependent prolyl cis ⁄ trans isomerase Pin1 docx

... destabilizing the double bond character of the pThr-Pro bond [26] Further evidence is available for the catalytic mechanism of Pin1 resembling more closely that of the other prolyl cis ⁄ trans isomerases, ... about the molecular mechanisms of the enzyme action Most importantly, we want to critically review the evidence that Pin1 would or would not act as a prolyl cis ⁄ trans isomerase Molecular mechanisms ... downstream of the proline could lead the WW domain to read the cis form in a reversed manner The initial screen for Pin1 substrates, which identiﬁed it as a phospho-dependent prolyl cis ⁄ trans isomerase, ...

Báo cáo khoa học: Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation potx

... deﬁned as physiological substrates for each protein kinase Speciﬁcally, protein phosphatase inhibitor-1 was used in the PKA, MAPK, Cdk1 and Ó FEBS 2004 Recombinant mouse AK as a protein phosphorylation ... migrating bands are Ó FEBS 2004 Recombinant mouse AK as a protein phosphorylation target (Eur J Biochem 271) 3551 Fig Phosphorylation of recombinant mAK-L by a panel of protein kinases PKC, PKA, ... (PPM) and phosphoamino acid analysis (PAAA) of mAK-L preparatively phosphorylated by PKC (E) Site-directed mutagenesis analysis of PKC phosphorylation of mAK-L The Coomassie stain and autoradiogram...

Báo cáo khoa học: Mechanisms of amyloid ﬁbril self-assembly and inhibition Model short peptides as a key research tool pptx

... information of the role of aromatic moieties in amyloid ﬁbril formation [36–41] A parameter-free model based on the mathematical analysis of many peptide fragments and their analogues had clearly ... short fragments, such as the pentapeptide fragments of the human calcitonin peptide and IAPP (Table 1), rapidly and efﬁciently form typical amyloid ﬁbrils Despite having a diameter larger than ... electrostatic charges and ⁄ or amide side-chains (glutamines and asparagines) is an important factor in the formation of efﬁcient amyloidogenic short peptide fragments More research should be undertaken...

Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 1) potx

... Sites A microbial pathogen can potentially enter any part of a host organism In general, the type of disease produced by a particular microbe is often a direct consequence of its route of entry ... presence of potentially pathogenic microbes in or on a host), infection (attachment and growth of pathogens and avoidance of host defenses), and disease (often, but not always, the result of activities ... ligands or adhesins for host receptors constitute a major area of study in the field of microbial pathogenesis Adhesins comprise a wide range of surface structures, not only anchoring the microbe to...

Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 2) potx

... chemokine herpesvirus type virus receptors (CCR5 and CXCR4) Epstein-Barr Envelope protein CD21 (=CR2) Adenovirus Fiber protein Coxsackie-adenovirus virus receptor (CAR) Coxsackievirus Viral coat ... and histocompatibility major class I antigens Bacterial Pathogens Neisseria spp Pili Membrane cofactor protein (CD46) Pseudomonas Pili and flagella Asialo-GM1 Lipopolysaccharide Cystic aeruginosa...

Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 3) doc

... residues on globosides of the human P blood groups Both of these types of pili have proteins located at the tips of the main pilus unit that are critical to the binding specificity of the whole pilus ... of the organism (polar pili) or distributed more evenly over the surface An individual cell may have pili with a variety of functions Most pili are made up of a major pilin protein subunit (molecular ... micrographic images of fixed cells of Pseudomonas aeruginosa Flagella (A) and pili (B) projecting out from the bacterial poles can be seen C and D Atomic force microscopic image of live P aeruginosa...

Chapter 114. Molecular Mechanisms of Microbial Pathogenesis (Part 4) potx

... Binding of the highly conserved Staphylococcus aureus surface protein clumping factor A (ClfA) to fibrinogen has been implicated in many aspects of pathogenesis The conserved outer-core portion of ... adherence of pathogenic Candida to host tissues These adhesins are expressed under certain environmental conditions (often associated with stress) and are crucial for pathogenesis of fungal infections ... surface polysaccharide composed of poly-N- acetylglucosamine One function of this polysaccharide is to promote binding to materials used in catheters and other types of implanted devices; poly-Nacetylglucosamine...

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