... dsDNA preparation induces maturation of mouse spleen and bone marrow DCs in vivo To evaluate the efficacy of vaccination with human dsDNA preparation, we chose a strategy whereby mice were treated ... treated with an agent alone, CP or dsDNA preparation, showed no marked increase in the number of mature DCs The peak of bone marrow DC maturation in the DNA and DNA+ CP groups was also on day In the ... 22 Coban C, Koyama S, Takeshita F, Akira S, Ishii KJ: Molecular and cellular mechanisms of DNA vaccines Hum Vaccin 2008, 4:453-456 23 Martin DA, Elkon KB: Intracellular mammalian DNA stimulates...