padilla - 2002 - can agency theory justify the regulation of insider trading

Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf

... in vivo footprinting as being protected in G0cells. The Cdc25C gene is not expressed in resting cellsor in cells in G1phase. Only in G2phase can strong transcription of the gene be detected. ... ARTICLE The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription Gerd A. Muăller and Kurt EngelandMolecular Oncology, Department of Obstetrics ... because inversion of the site in the humanCdc25C promoter resulted in a deregulation of cell cycle-dependent transcription. Deregulation is alsoobserved when the CDE alone is inverted [26].Interestingly,...

Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

... alignment of AP-2a, AP-2b, AP-2c, AP-2d, and AP-2e. The proline-rich and glutamine-rich N-terminus, which is important fortransactivation, is shown in yellow, and contains the PY-motif (green). The ... 2009 The Authors Journal compilation ê 2009 FEBS REVIEW ARTICLE Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development Ann-Kathrin Wenke and Anja K. BosserhoffInstitute ... studyascribe the regulation of outgrowth of limb buds and patterning of the digits to the chicken AP-2. The role of AP-2a was further studied in zebraﬁsh.It was conﬁrmed that AP-2a is an essential...

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... control was maintained in a standard incubator with 21% O2. The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... overexpression, indicating that miR-27 does not play an important role in myogenicdifferentiation. Taken together, these results illustrate a critical and speciﬁc role of miR-27 in the regulation of adipogenic ... Dharmacon, Lafayette, CO, USA). Usingquantitative real-time PCR analysis, we found a > 60-fold increase in mature miR-2 7a and miR-27b in the transfected preadipocytes. As shown in Fig. 2A, miR-2 7a, ...

Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx

... integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensing of glutamine-induced hepatocyte swelling by integrinsfeeds into ... 2007 The Authors Journal compilation ª 2007 FEBS MINIREVIEW Osmosensing and signaling in the regulation of mammalian cell function Freimut Schliess, Roland Reinehr and Dieter HaăussingerClinic ... cell volume to a functional outcome.This minireview summarizes recent progress in the understanding of how osmosensing and osmosignaling integrate into the overall context of growthfactor signaling...

Tài liệu Car-tastrophe - How federal policy can help, not hinder, the greening of the automobile ppt

... and conclusions do not necessarily represent those of the board, supporters, or sta of PRI. Car-tastrophe How federal policy can help, not hinder, the greening of the automobile By Amy Kaleita, ... http://www.eia.doe.gov/oiaf/aeo/arra.html (veried 19 November 2010). 6 4 Car-tastrophe How federal policy can help, not hinder, the greening of the automobile By Amy Kaleita, Ph.D.January 2011Paciﬁc Research Institute ... Green of the American Enterprise Institute and Joel Schwartz for their formal review of this study. Any remaining errors or omissions are the sole responsibility of the author. As the author of...

Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For ... between Src family kinases (SFKs), stabilized by binding of the phosphorylatedC-terminus to the SH2 domain and ⁄ or binding of the SH2 kinase linker to the SH3 domain, lock the molecules in a closed ... Y527FD1)250N-terminal, SH3, SH2, kinase domain and C-terminusDeletion of N-terminal, SH3 and SH2 domain of kinase- dead n -Src B. R. Groveman et al. A novel function of Src SH2 and SH3 domains FEBS Journal...

Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

... muscles and several cancer cell lines [94].Table 1. Role of nuclear actin- binding proteins interacting with the androgen receptor. AR, androgen receptor; LBD, ligand-binding domain. Actin- bindingproteinTargetingsequence ... ARTICLE Nuclear actin and actin- binding proteins in the regulation of transcription and gene expression Bin Zheng1, Mei Han1, Michel Bernier2 and Jin-kun Wen11 Department of Biochemistry and ... members of the actin- bindingLIM protein (ABLIM) family, ABLIM-2 and -3, asSTARS-interacting proteins. These novel proteins con-tain four LIM domains and a C-terminal villin head-piece domain,...

Project Management Theory and the Management of Research Projects pptx

... issues of project management theory 2 as the status and foundations of project management theory (subsection 1.1) and the nature and life cycle of projects (subsection 1.2).1.1 Project management ... between the tasks of the day-to-day administration of a research work place and the management of research work. The research project leader’s task belongs to the last category and a research project ... in 1 Project Management Theory and the Management of Research Projects Erik Ernø-KjølhedeWP 3/2000January 2000 30An important special feature of many research projects is that research project...

Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf

... increases in glucose uptake and glycogen synthesisallowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin. However, one of the potential difﬁculties in interpreting ... phosphatidylinositol3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammaliantarget of rapamycin (mTOR) pathway in the L-leucine-inducedup -regulation ... of GSK3 (using Li or SB-415286) appears to be sufﬁcient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinasepotentiates insulin action in muscle of insulin-resistant...

Báo cáo khoa học: MicroRNAs and the regulation of ﬁbrosis potx

... within the 3Â-UTR of target genes. The speciﬁcity of the miRNA guide strand is thought to bemediated by the ‘seed’ region localized between resi-dues 2 and 8 at the 5Â end [57], and the specicity ... of organs including the heart, kidney, liver and lung. In this review, we summarize our current understanding of the role of miRNAs in the development of tissue ﬁbrosis and their potential asnovel ... remodeling and ﬁbrosis can ultimately lead to failure of a number of organs. Although current treatments typically target the inﬂammatory response, the mechanism of ﬁbrosis is poorly understood and there...

Báo cáo khoa học: Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells doc

... arrange-ment of mitochondria in the cells, in the changes in the kinetics of regulation of mitochondrial respiration by exogenous ADP and ATP, and in the directchannelling of endogenous ADP and ATP ... disorganization of the regular intracellular mitochondrial arrangement,calcium induced changes in the kinetics of regulation of the respiration rate (Fig. 6). This concerned mostly the changes in the apparent ... Reversibility of the effects of calcium-induced contraction of cardiomyo-cytes on the kinetics of regulation of mito-chondrial respiration by exogenous ADP. The kinetics of respiratory regulation...

Quantum information theory and the foundations of quantum mechanics c timpson

... homunculi.)1.2 The Shannon Information and related concepts The technical concept of information re le vant to our discussion, the Shannon informa-tion, ﬁnds its home in the context of communication theory. ... particular the distinction between the technical and non-technicalnotions of information; in Part II, I turn to consider, in light of the preceding discussion, the question of what rˆole the concept ... measure of informa tion, the quantum noiseless coding theorem introduces the concept of the qubit as a measure of quantum information, characterising the quantum source.By an ingenious argument, the...

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Báo cáo Y học: Elucidation of the role of fructose 2,6-bisphosphate in the regulation of glucose fluxes in mice usingin vivo 13 C NMR measurements of hepatic carbohydrate metabolism docx

... the ratioofglycogenC6andC1(Glyc6/Glyc1), we concludethattherelativeisotopicenrichmentinC6ofGlc6P wassigniﬁcantly higher in ADM than that in control mice. Therateof 13 C label incorporation into ... glycogen C6 even in the presence of decreased activity of the indirect pathway,provided that the increase in glycolytic ﬂux exceeded the decreased gluconeogenic ﬂux substantially. The ability of the ... liverLabel incorporation into the glycogen C1 reﬂects glycogensynthesis via the direct pathway (glucose glucose- 6-phos-phateﬁglycogen), whereas label incorporation into the glycogen C6 reﬂects activity...

Báo cáo Y học: Identiﬁcation of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx

... of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity Fumitaka Wada1, Akio Nakamura2, ... might be similar to that bywhich they inhibit the enzymatic activity of TGase 4.Hydrolysing activity of GTP was also found in the puriﬁed PpTGase protein as in the case of TGase 2.Mammalian TGase ... low in the deduced sequence of the Physarum TGase, the middle region of the sequence issigniﬁcantly conserved. The sequences around the GTP- binding region, catalytic site, and Ca2+-binding...

padilla - 2002 - can agency theory justify the regulation of insider trading

... Therefore, the profit-and-loss system is another system shareholders have to evaluate the behavior of their insiders (managers) and to sanction them. CAN AGENCY THEORY JUSTIFY THE REGULATION OF INSIDER ... lessening of the con- trol relation between shareholders and their insiders: legal restrictions on CAN AGENCY THEORY JUSTIFY THE REGULATION OF INSIDER TRADING? 25 financial institutions, insider trading ... takeover, ousts the board of directors. CAN AGENCY THEORY JUSTIFY THE REGULATION OF INSIDER TRADING? 9 to those to whom they owe their positions, that is to say, the management who proposed them as...

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