design, synthesis, and biological evaluation of new anti-cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of chagas

... diagram of crystal structure o f CD2 CD58 complex and crystal structure of rat CD2. (A) Ribbon diagram of crystal structure of CD2 CD58 (LFA-3) complex. Starting positions of peptides for docking ... tructure of the surface epitopes of the CD2 protein. Docking studies of CD2 peptides and CD58 protein revealed the possible binding sites of the cyclic...

Ngày tải lên: 19/02/2014, 13:20

... bodies, of the basidiomycete Macrolepiota procera, and have characterized some of its natural and recombinant members. Results Isolation of cysteine- protease inhibitors from M. procera Cysteine protease ... promoter sequences have a typical TATA box (TATAAAA) present at position )85, and a putative transcription initiation site (CTAGTCC) at position )55, indicat...

Ngày tải lên: 16/03/2014, 02:20

... We have determined the secondary structure of the cyclic OP analogs by two-dimensional 1 H-NMR and molecular dynamic simulation, and we have investigated the biological activity of these analogs ... we have shown that head-to-tail cyclization of the ODN agonist OP and the weak antagonist [ D-Leu5]OP enhances their biological activity on rat astrocytes l...

Ngày tải lên: 24/03/2014, 04:21

... Sciences and Humanities Research Council of Canada Doctoral Fellowship. ASCILITE ’98 467 Delivering Health Education via the Web: Design and Formative Evaluation . . . The Health and Health Behaviour ... 473 Delivering Health Education via the Web: Design and Formative Evaluation . . . Figure 4: An example of a Submit Page in the Web...

Ngày tải lên: 28/03/2014, 21:20

... tibial Less Invasive Stabilization System (LISS) plate [AO-ASIF] for the treatment of paediatric supracondylar fracture of femur: a case report Hoi Yan Lam * , Chun Kwong Lo, Kai Yin Cheung Abstract Paediatric ... intra-articular pin pla cement, causing septic arthritis and a risk of damaging the growth plate. An external fixator is also use...

Ngày tải lên: 20/06/2014, 04:20

... (1a–k), and new three 3H-pyrido[2,3-b]pyrazolo[3,4-h]- 1,6-naphthyridine derivatives (2a–c). 1 Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]- 1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6- naphthyridines ... acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon. Synthesis and anti-HSV-1 eva...

Ngày tải lên: 20/06/2014, 20:20

... Article Design and Experimental Evaluation of a Vehicular Network Based on NEMO and MANET Manabu Tsukada, 1 Jos ´ e Santa, 2 Oliv ier Mehani, 1 Yacine Khaled, 1 and Thierry Ernst 1 1 INRIA Paris, ... paper, regarding NEMO and MANET, are also introduced, such as Multihoming, Route Optimization, and MANEMO. 2.1. VANET. Vehicular Ad hoc Networks (VANET ) are...

Ngày tải lên: 21/06/2014, 08:20

... pages doi:10.1155/2008/250895 Research Article Design and Performance Evaluation of an Adaptive Resource Management Framework for Distributed Real-Time and Embedded Systems Nishanth Shankaran, 1 Nilabja Roy, 1 Douglas ... between resource management algorithms and middleware platforms and im- prove flexibility. (iii) Design of a framework determi...

Ngày tải lên: 22/06/2014, 00:20

... __________________ Abstract iii of forward error correction coding (FEC). System capacity (for BER = 10 −12 ) is shown to be 23 Gb/s without coding, and 75 Gb/s with a (255,239) Reed Solomon code. The effect of non-rectangular ... spectrum- sliced FSK systems using optical preamplifier receivers are shown, for the first time, to perform better in a peak optical power limited enviro...

Ngày tải lên: 06/08/2014, 00:20

... of May on a sample of ten control and 15 thinned trees from each plot Original article Intra- and interannual variations of transpiration, leaf area index and radial growth ... of transpiration were successively analysed as a consequence of i) seasonal and annual variations in leaf area index and ii) soil water balance. F...

Ngày tải lên: 08/08/2014, 18:21

... al.: Effects of radiation therapy on tissue and serum concentrations of tumour associated trypsin inhibitor and their prognostic significance in rectal cancer patients. Radiation Oncology 2011 ... 6:100 http://www.ro-journal.com/content/6/1/100 Page 10 of 10 RESEARC H Open Access Effects of radiation therapy on tissue and serum conce...

Ngày tải lên: 09/08/2014, 09:21

... number not for citation purposes) Head & Face Medicine Open Access Research Biological and biomechanical evaluation of interface reaction at conical screw-type implants Andre Büchter* 1 , ... after 28 days of osseointegration. SEM of implantation sites in tibia specimens at different mag-nificationsFigure 5 SEM of implantation sites in tibia specimens at diff...

Ngày tải lên: 11/08/2014, 23:22

... Evaluation of New Anti-cancer Nitrogen-Containing Combretastatins and Novel Cysteine Protease Inhibitors for the Treatment of Chagas Rogelio Siles Mentor: Kevin G. Pinney, Ph.D. In an effort ... Six: Synthesis, Design and Biochemical Evaluation of Cysteine Protease Inhibitors: Novel Compounds for Chagas Disease Treatment 143...

Ngày tải lên: 14/11/2014, 11:32