... common drug used on treatment of HSV infections [3–5] However, the widespread use of these compounds has been associated with the emergence of drug- resistant HSV strains [5] The discovery ofnew ... mechanisms of action could offer an additional strategy against drug resistance of viruses Several examples of non-nucleoside inhibitors have been proposed as candidate drugs for the treatment of herpes ... primary cause of facial lesions (mouth, lips, and eyes) in humans The widespread use of acyclovir and nucleoside analogues has led to emergence of HSV strains that are resistant to these drugs Recently,...
... profitability of the investment The variability of this profitability when there are changes in the percentage of the stand retained does seem to differ among the cases that are studied: some of ... preservation of biodiversity and the landscape, etc., are the lengthening of the rotation, retention of part of the trees in final cutting and, to a lesser extent, the thinning regime and the level of ... the option of leaving 25% of the volume at the end of the first cutting becomes the most appealing If we compare the alternative of lengthening the rotation with increases in the amount of wood...
... confirmed by many other studies In a study of 61 industry-sponsored trials of nonsteroidal anti-inflammatory drugs [17], 100% of trials found the sponsor’s drugs comparable or superior to the comparator; ... violate the principle of equipoise Publication bias Results The results from every RCT (45 out of 45) favored the drugof the sponsor (P < 0.0001) Discussion Clearly, the results of these trials could ... value of outcomes after accepting the trial This comparison does not depend on the expected values of the individual arms of the RCT but on their pooled average For example, consider an RCT of a new...
... for the evaluationof best suited reference gene(s) for normalization of qPCR data in a given set of biological samples Recognizing the importance of reference genes in normalization of RT-qPCR ... 10 μL of diluted cDNA (1:50), 0.2 μM of each primer, 50 μM of each dNTP, 1× PCR Buffer (Invitrogen), mM MgCl2, μL of SYBR®Green I (Molecular Probes) water diluted (1:10000), and 0.25 units of Platinum ... GhUBQ14 Table Values of efficiency ± standard deviation (SD) of the primers of the housekeeping genes and average values of quantification cycle (Cq) ± standard deviation (SD) of biological replicates...
... based on their mode of action and the phase of the cell cycle in which the drug acts If the action of the drug is most effective at any particular phase of the cell cycle, the drug is called a cell ... regions of the 1H-NMR spectrum of E isomer 4b 93 4.4 Expanded region of the 1H-NMR (CD2Cl2) spectrum of compound 13 99 4.5 Minimimum-energy structure of compound 13 99 4.6 1H-NMR and DEPT 135 of compound ... structure of compound 66 202 9.1 Minimun energy conformations of compounds 59, 62 and 66 223 9.2 One of the best calculated orientations of compound 66 in the active site of cruzain 225 ix LIST OF TABLES...
... Incubation of samples at reference temperature for duration of shelf life Incubation of plates 24-28 h @ 23°C- 25°C Plating of samples, Incubation as at left, Evaluationof results of plating Evaluation ... Guideline for Microbiological Evaluationof Chilled Dairy Products Procedural Flow Chart Evaluationof customer requirements Verification of plant pre-requisites Commissioning of equipment Filling tests ... Procedures & Guidelines Guideline for Microbiological Evaluationof Chilled Dairy ProductsEvaluationof customer requirements It is the responsibility of the local Tetra Pak Market Company to fully...
... for Microbiological Evaluationof Commercially Sterile Products 4.4.3 Choice of sampling plans The table below will assist in the choice of sample size and the evaluationof the test runs The ... tests start The purpose of the filling test is fold: • Finalisation of software program of the controller • Calibration of instruments and control loops • Mechanical test of the complete line with ... introduction ofnewproducts 1.3 Low acid vs High acid products This guideline distinguishes between procedures for low-acid products (pH >4,6), described in chapter and high acid products (pH...
... CHALLENGES OF HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ASSAY OF COMBINED DRUGPRODUCTS Éva Kalmár, Pharm.D Supervisors Prof György Dombi, Ph.D., C.Sc Gerda Szakonyi, Ph.D., Pharm.D University of ... Szeged Faculty of Pharmacy Institute of Pharmaceutical Analysis Szeged 2014 TABLE OF CONTENTS TABLE OF CONTENTS Abbreviations iii List of figures iv List of tables ... solidus compositus iii LIST OF FIGURES List of figures Figure Potential uptake locations of the drug from the different sections of the rectum Figure log D vs pH curves of paracetamol, ASA and papaverine...
... EVALUATIONOF NATURAL PRODUCTS AND THEIR ANALOGS AS NEW CANCER CHEMOTHERAPEUTIC AGENTS FANG ZHANXIONG (B.Sc.(Hons.) NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF ... years i TABLE OF CONTENTS TABLE OF CONTENTS ii SUMMARY iv LIST OF TABLES vi LIST OF FIGURES vii LIST OF SCHEMES ix LIST OF ABBREVIATIONS x Chapter 1: Introduction 1.1.1 Overview of Cancer 1.1.2 ... cause of death in the world and there is a continual search for new anti cancer drugs Today, more than half of the clinically available drugs are either natural products or derived from natural products...
... 1. FT-IR spectra of PA (a) and pullulan (b) 500 Stability and in vivo evaluationof pullulan acetate 555 (2008) also reported that the smaller size of NPs may be in favor of longer circulation ... Safety, pharmacokinetics and biodistribution studies of a beta-galactoside prodrug of doxorubicin for improvement of tumor selective chemotherapy Drug Dev Ind Pharm 34:789–95 Fessi, H., Puisieux, ... Bioavailability (BA) is a measurement of the rate and extent of a therapeutically active drug that reaches the systemic circulation and is available at the site of action When a medication is administered...
... for import or export ofnewproducts Trade openness encourages technology flows and awareness about and availability ofnew products, encouraging the faster adoption ofnewproducts (Perkins and ... years of takeoff across the same set of countries Convergence in the year of takeoff may occur due to two reasons First, there may be a convergence in the year of commercialization ofnewproducts ... considerably on the type ofproducts Because timesto-takeoff of fun products are more similar across countries and takeoff of fun products is converging faster over time than that for work products, they...
... Figure Trend ofnew product (source: Web of Science ® 2010) Mohammadjafari et al 11853 Figure Schematic diagram of the literature Department of Design Department of Production Department of Procurement ... 2005) and New product development New product development (NPD) is a business process for developing newproducts for a company, whether it is an upgrade of an existing product or a new concept ... SMEs and new product development Future research can improve 11852 Afr J Bus Manage Figure Trend of project management (source: Web of Science ® 2010) Figure Trend of SMEs (source: Web of Science...
... indicates the importance of RGDechiHCit in the selective inhibition of endothelial aVb3 integrin Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, offering clinical ... angiogenesis The knowledge of molecular basis of this complex mechanism remains a challenge of fascinating interest, with clinical implications for treatment of a large number of pathophysiological ... issue by increasing the times of application of the drug both in vitro and in vivo, or by reducing the times of observation This issue can be solved by the use of a more stable aromatic pharmacophore...
... is a national laboratory of the U.S Department of Energy, Office of Energy Efficiency & Renewable Energy, operated by the Alliance for Sustainable Energy, LLC National Renewable Energy Laboratory ... Analysis Assumptions for New and Retrofit Residential 25 3.3.3 Economic Analysis Assumptions for New and Retrofit Commercial 26 3.4 Cooling Performance 26 3.4.1 New Residential ... 28 3.4.2 Retrofit Residential 30 3.4.3 New and Retrofit Commercial 31 3.5 Energy Performance 32 3.5.1 New Residential 32 3.5.2 Retrofit Residential...
... 5a), but the percentage of log products increased at the same time (Fig. 5b) In other words, with the reduction of total timber products in these forests the quality ofproducts also changed to ... Products, Consuming in Iran Annual reports of the Forest and Range Organization of Iran Tehran, Forest and Range Organization of Iran: 43–45 K M (2007): The study of import and exports of ... Industrial Office of the Forest organization of Iran: 28–30 S H (2000): Evaluating of quality and quantity of importing timbers to Iran [MSc Thesis.] Tehran, University of Azad of Iran: 186–189...
... 20 the use of hypothermic cardioplegia That explains why the hearts of the control and the experimental group Development and Evaluationof a New Apparatus for Continuous Perfusion of Isolated ... methods were observed by time of first reaction of the heart to the reperfusion of the normothermic Krebs perfusate, on-set of spontaneous heart beat, frequency of left ventricular fibrillation, ... The hearts of the experimental group showed a first beating at an average of 2.8 minutes while the hearts of the control group showed the first response of fibrillation at an average of 3.8 minutes...
... behavior of tumors of different sizes and the outcome of patients with tumors of different sizes may not be uniform, and certainly the prognostic significance of tumor size requires further reevaluation ... types of cancer, the prognosis of HCC is determined not only by the anatomical involvement and growth pattern of the tumor but also by pathophysiological features such as the presence of liver ... [10], which was introduced in 2009, is a modified version of the 6th edition (TNM-6) of this system The major modifications of this new system are: stage IIIA includes only multiple tumors or...