7—evaluation of new aggregate sources

... used on treatment of HSV infections [3–5] However, the widespread use of these compounds has been associated with the emergence of drug-resistant HSV strains [5] The discovery of new non-nucleoside ... mechanisms of action could offer an additional strategy against drug resistance of viruses Several examples of non-nucleoside inhibitors have been proposed as candidate drugs for the treatment of herpes ... activity of 3H-benzo[b]pyrazolo[3,4h]-1,6-naphthyridines In the course of our search for new 1,6-naphthyridines derivatives with potential activity against HSV-1, we have synthesized and evaluated new...

Ngày tải lên: 20/06/2014, 20:20

... preservation of biodiversity and the landscape, etc., are the lengthening of the rotation, retention of part of the trees in final cutting and, to a lesser extent, the thinning regime and the level of ... the option of leaving 25% of the volume at the end of the first cutting becomes the most appealing If we compare the alternative of lengthening the rotation with increases in the amount of wood ... instead of continuing with traditional management implies to trade off 75% of the LEV for an increase in the final volume and veneer volume of 10% and 4%, respectively Despite the financial cost of...

Ngày tải lên: 08/08/2014, 01:22

... the evaluation of best suited reference gene(s) for normalization of qPCR data in a given set of biological samples Recognizing the importance of reference genes in normalization of RT-qPCR data, ... 10 μL of diluted cDNA (1:50), 0.2 μM of each primer, 50 μM of each dNTP, 1× PCR Buffer (Invitrogen), mM MgCl2, μL of SYBR®Green I (Molecular Probes) water diluted (1:10000), and 0.25 units of Platinum ... GhUBQ14 Table Values of efficiency ± standard deviation (SD) of the primers of the housekeeping genes and average values of quantification cycle (Cq) ± standard deviation (SD) of biological replicates...

Ngày tải lên: 12/08/2014, 03:21

... which may lead to the further development of more selective cruzain inhibitors TABLE OF CONTENTS List of Figures vii List of Tables x List of Schemes xi List of Abbreviations xiii Acknowledgments ... regions of the 1H-NMR spectrum of E isomer 4b 93 4.4 Expanded region of the 1H-NMR (CD2Cl2) spectrum of compound 13 99 4.5 Minimimum-energy structure of compound 13 99 4.6 1H-NMR and DEPT 135 of compound ... structure of compound 66 202 9.1 Minimun energy conformations of compounds 59, 62 and 66 223 9.2 One of the best calculated orientations of compound 66 in the active site of cruzain 225 ix LIST OF TABLES...

Ngày tải lên: 14/11/2014, 11:32

... both to minimize roundoff error, and also (as pointed out by A.J Glassman) to ensure that no choice of branch for the complex cube root can result in the spurious loss of a distinct root If you ... Rubber Co.), pp 130–133 Pachner, J 1983, Handbook of Numerical Analysis Applications (New York: McGraw-Hill), §6.1 McKelvey, J.P 1984, American Journal of Physics, vol 52, pp 269–270; see also vol ... is to choose h properly, an issue we now discuss: There are two sources of error in equation (5.7.1), truncation error and roundoff error The truncation error comes from higher terms in the Taylor...

Ngày tải lên: 24/12/2013, 12:16

... indicates the importance of RGDechiHCit in the selective inhibition of endothelial aVb3 integrin Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, offering clinical ... angiogenesis The knowledge of molecular basis of this complex mechanism remains a challenge of fascinating interest, with clinical implications for treatment of a large number of pathophysiological ... issue by increasing the times of application of the drug both in vitro and in vivo, or by reducing the times of observation This issue can be solved by the use of a more stable aromatic pharmacophore...

Ngày tải lên: 18/06/2014, 16:20

... array processing of near-field sources, as shown in Figure Suppose that there are K sources of interest with complex baseband representations si (t), i = 1, , K Let the band of interest have ... nonzero eigenvalues) of ¯ C are easily matched with those of C by contrasting the two sets of eigenvectors [12], while they can be both considered as estimates of the K column vectors of A, it is easy ... Estimation for 3D Parameters of Near-Field Sources where d is the interelement spacing of the uniform linear array, while λi , ri , and θi are the wavelength, range, and bearing of the ith source, respectively...

Ngày tải lên: 23/06/2014, 01:20

... national laboratory of the U.S Department of Energy, Office of Energy Efficiency & Renewable Energy, operated by the Alliance for Sustainable Energy, LLC National Renewable Energy Laboratory 1617 Cole ... Analysis Assumptions for New and Retrofit Residential 25 3.3.3 Economic Analysis Assumptions for New and Retrofit Commercial 26 3.4 Cooling Performance 26 3.4.1 New Residential ... 28 3.4.2 Retrofit Residential 30 3.4.3 New and Retrofit Commercial 31 3.5 Energy Performance 32 3.5.1 New Residential 32 3.5.2 Retrofit Residential...

Ngày tải lên: 27/06/2014, 14:20

... Messages were product-focused with little regard to providing value beyond the intrinsic value of the product NEW MARKETING MODEL Use human engagement and dialogue to drive customer preference and loyalty ... Mentions Share of Voice IF YOUR POINT IS SALES THEN WHAT MATTERS IS: Web Traffic Time Spent on Site Bounce Rate Repeat Visits Content Acceptance Followers, Friends, Fans Social Mentions Share of Voice ... outreach elements, digital and traditional, lead back to the center of your strategy – your website; the digital embodiment of your brand SOMETIMES YOU ONE SILOANOTHER WEBSITE NEED ESPECIALLY...

Ngày tải lên: 03/07/2014, 09:44

... methods were observed by time of first reaction of the heart to the reperfusion of the normothermic Krebs perfusate, on-set of spontaneous heart beat, frequency of left ventricular fibrillation, ... The hearts of the experimental group showed a first beating at an average of 2.8 minutes while the hearts of the control group showed the first response of fibrillation at an average of 3.8 minutes ... P 10 The value of “P180” is the last coronary pressure after 180 minutes of perfusion The value of “P10” is the first coronary pressure after 10 minutes of perfusion The mean of these variations...

Ngày tải lên: 07/08/2014, 15:20

... biological behavior of tumors of different sizes and the outcome of patients with tumors of different sizes may not be uniform, and certainly the prognostic significance of tumor size requires ... types of cancer, the prognosis of HCC is determined not only by the anatomical involvement and growth pattern of the tumor but also by pathophysiological features such as the presence of liver ... [10], which was introduced in 2009, is a modified version of the 6th edition (TNM-6) of this system The major modifications of this new system are: stage IIIA includes only multiple tumors or...

Ngày tải lên: 09/08/2014, 02:21

... any loss of efficiency after 12 hours of continuous use, and reached a steady state in terms of temperature and humidity after only 15 of use To improve the efficiency of HMEs, use of two other ... temperature of 25.1 ± 1.4°C In normal conditions the temperature of expired gases ranges between 28 and 32°C with an AH of 27–33 mgH2O/l [22,23], and thus a temperature of 29–33°C with an AH of 28–35 ... evaporation of the sterile water is proportional to the dryness of the gas, and so the difference in temperature between the dry and wet probe is related to the dryness of the gas [19] At the start of...

Ngày tải lên: 12/08/2014, 20:20

... a routine level of activity or does not protect the privacy of their vocal conversations during the recording period The results of this study describe a newly developed method of objectively ... Protection Office of the Penn State College of Medicine approved the study Cough definitions and recording analysis As has been done previously, a "cough bout" was defined as a one-second period of time ... analysis software: Graphical user interface (GUI) Data analysis software: Graphical user interface (GUI) and audio counts, agreement of audio counts between investigators, and agreement of video...

Ngày tải lên: 13/08/2014, 08:20

... suitability of the objectives of the material to the needs of students within the framework of the English program .31 3.3.2 The suitability of the contents of the material to the needs of students ... % of grammar, 7.2% and 18.9% of vocabulary, 9.8% and 24.5% of skills work, 7.9% and 7.9% of everyday English, 20.4% and 23.4% of writing Teachers and students’ opinions about the number of new ... number of new words is suitable while only 74% of students have the same idea 26% of students think new words is many in each unit, so it is difficult to learn all 3.2.3 The suitability of the...

Ngày tải lên: 19/03/2015, 10:34

... order of the appearance of the cultural content of the countries in the course book New English File Pre-Intermediate? Figure 3.1.5: Students’ opinions about the order of the appearance of kinds of ... illustrates the rank of the kind of cultural content embedded in the course book In the group 1, half of informants shared the same view of the first position of cultures of English speaking countries, ... stimulus for learning, offers teachers to organize the process of teaching and learning Moreover, it must have a view of the nature of language and learning, the nature of the learning tasks,...

Ngày tải lên: 10/07/2015, 14:50

... Comparison of iF between the three cases With a sense of the impact of the background ventilation system on the flow pattern of the indoor air, thus influencing the concentration of exhaled contaminated ... cases with closer distances, higher concentration of exhaled air is measured at the breathing zone of HP, thus the change of iF over the half hour of the three cases when no PE is used is shown ... unwanted local cooling of the body caused by air movement, the increase of draft rating is not preferred The figures show that the increase of PE flow rate also brings an increase of DR at the neck/ear...

Ngày tải lên: 10/09/2015, 09:21

... years i TABLE OF CONTENTS TABLE OF CONTENTS ii SUMMARY iv LIST OF TABLES vi LIST OF FIGURES vii LIST OF SCHEMES ix LIST OF ABBREVIATIONS x Chapter 1: Introduction 1.1.1 Overview of Cancer 1.1.2 ... Optimization of the synthesis of 3-4 119 Table 3.2 Cytotoxicity of synthesized compounds against various cancer cells 122 Table 4.1 Optimization of the synthesis of 4-7a 137 Table 4.2 List of compounds ... No of 15 Approvals 10 1971- 1976- 1981- 1986- 1991- 1996- 20011975 1980 1985 1990 1995 2000 2005 Figure 1.3 Number of approval of new drugs for cancer by FDA.40 Despite the development of new...

Ngày tải lên: 10/09/2015, 15:49

... level of renewable energy sources, each renewable energy source has a capacity of 250 MW Therefore, the total capacity of all renewable sources is 1000 MW, same as the first two cases 36 G G Renewable ... vii LIST OF TABLES 2.1 2.2 2.3 2.4 2.5 2.6 Accuracy Comparison of Reliability Indices of Case Variance Comparison of Reliability Indices of Case Accuracy Comparison of Reliability Indices of Case ... Indices of Case Variance Comparison of Reliability Indices of Case Accuracy Comparison of Reliability Indices of Case Variance Comparison of Reliability Indices of Case 18 19 19 19 20 20 3.1...

Ngày tải lên: 12/10/2015, 17:34