The Molecular Mechanism of Break Induced Replication

... Disclaimer Title of Thesis/Dissertation: For the degree of Choose your degree I certify that in the preparation of this thesis, I have observed the provisions of Purdue University ... Approved by: Head of the Graduate Program Date Sandeep Ayyar The Molecular Mechanism of Break Induced Replication Master of Science Dr. Anna Ma...

Ngày tải lên: 24/08/2014, 13:24

... sensible strategy if the concentration of the oligomeric species were also decreased. Mechanism of neurotoxicity in FAP: the lesson from other amyloidoses A number of studies have examined the mechanism of neurotoxicity ... showing the location of amyloidogenic mutations and position of b-strands. (A) The struc- ture of the polypeptide backbone of the two c...

Ngày tải lên: 07/03/2014, 10:20

... was detected in the synovial fluids from RA patients. The ratio of the concentration of soluble RANKL to that of OPG was significantly higher in the synovial fluids of RA patients than in those of patients ... differentiation. In conclusion, control of the production of RANKL, of OPG and of other T-cell-derived cytokines in RA patients will provide a clue for strat...

Ngày tải lên: 09/08/2014, 06:22

... into the lumen of the SR by the Ca 2+ pump, SERCA2a, making Ca 2+ available for the next contraction (1). Therefore, the rate of Ca 2+ transport by SERCA2a determines both the rate of myofilament ... small amount of extracellular “activator” Ca 2+ to enter the cell. Then, through the process known as Ca 2+ induced Ca 2+ release, the “activator” Ca 2+ tri...

Ngày tải lên: 24/08/2014, 11:06

... after the cell has “confirmed” the absence of a second end to participate in repair, and both the distance between and orientation of the DSB ends affect whether the cell senses the break as ... 2.2). Rather, mitotic GC of a DSB proceeds through: 1) 5’-to-3’ resection of both sides of the break, 2) invasion by at least one of the ssDNA ends into the donor s...

Ngày tải lên: 24/08/2014, 11:07

... coli agmatinase, of the loop indicated by the letter a. Fig. 5. Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the modelled structures of wild-type ... indicating that the environ- ment of tryptophan residues is essentially conserved in the mutant enzyme. On the other hand, the absence of major differ...

Ngày tải lên: 21/02/2014, 01:21

... eggs in the one-cell stage to visualize the localization and to mea- sure the mobility of the components in the PGCs. The medaka embryo was peeled off the chorion, and the segment containing the ... reported that, in Drosophila, the function of the nuage might be related to the protection of the genome via repression of the selfish genetic elements in the...

Ngày tải lên: 18/02/2014, 16:20

... may indicate that the steric limitation of the enzyme’s binding pocket takes place in the area between the ortho and para positions of the aromatic substrate. On the basis of these results, aniline ... AtdA3 are critical for the activity of the enzyme and provide good start- ing points for the study of the molecular determi- nants of the substrate specificit...

Ngày tải lên: 19/02/2014, 02:20

... is composed of residues 25–540. The overall structure of the model of IPU and the mutated residues in this study are shown in Fig. 3. To elucidate the mechanism of the substrate recognition of IPU, ... panose (data not shown). Prediction of the positions of amino acid residues whose substitutions resulted in the reduction of the IPU activity While the study...

Ngày tải lên: 19/02/2014, 16:20

... oxidize them [19]. On the other hand, this fact does not represent proof of the presence of one or two oxidizing equivalents on the decay product of Cpd I. The EPR spectrum of a spin-trapped radical ... formulated a hypo- thesis that describes an integrated vision of the catalytic mechanism of both enzymes. The main points are: (a) a re-evaluation of the role of...

Ngày tải lên: 20/02/2014, 02:21