... tensile test specimens and mm in diameter and a lengthen of 50 mm for the samples used for compressive tests The compression and the tensile tests of bulk metallic glasses were conducted at different ... and fatigue tests ofthe pure Cu and Cu-Al single crystals, Cu bicrystals and ultrafine-grained Al-Cu polycrystals were performed on Shimadzu testing machine After fracture, all the specimens were ... thay b n riêng c a v t li u Ch HKV H phá h y d c theo m t ng su t pháp l n nh t, θT = 90o , ta m i có σ T = σ o [4]; Tuy v y, h u h t HKV H phá h y theo mode trư t v i góc trư t khác nhau, tương...
... in the one-cell stage to visualize the localization and to measure the mobility ofthe components in the PGCs The medaka embryo was peeled off the chorion, and the segment containing the part of ... of OlvasGFP reveals the dynamic natureofthe nuage Schematic diagram ofthe preparation of PGCs of medaka specimen (A) OlvasGFP was expressed in the medaka PGC at stage 24 and localized in the ... investigation ofthe features of PGCs Results Time-lapse laser scanning microscopy (LSM) image analysis of Olvas reveals the dynamic natureofthe nuage Previous studies showed that the 3Â-UTR of genes...
... (pTDN1) [14] The lack of characterization ofthe structural determinant ofthe substrate specificity ofthe AtdA enzyme has thus limited its development as a biocatalyst for the bioremediation of a wide ... reported which ofthe five genes control the substrate specificity ofthe AtdA enzyme The objective of this study was to identify and probe the residues determining the activity as well as the substrate ... may indicate that the steric limitation ofthe enzyme’s binding pocket takes place in the area between the ortho and para positions ofthe aromatic substrate On the basis of these results, aniline...
... wild-type ALP I On the other hand, the Tm of D266N/Y269A-ALP I increased by only °C The denaturation temperature indicates the stability ofthe structure ofthe protein The difference ofthe increments ... surrounding residues ofthe depression, and the side chain ofthe mutated residue might restrain the mobility ofthe N-terminal region on the surface by interaction with the main chain of Lys26 by van ... the substitutions did not influence the activities or specificity ofthe mutant enzymes The N-terminal region of ALP I was also on the surface The side chains of Ile10 and Tyr11 were close to the...
... bullet-proof fashion that will stand the test of time The second, and for the working mathematician the most important, aspect of proof is that the proof of a new theorem explains why the result ... the bulk of their time proving theorems, it is nevertheless the case that proof is the lingua franca of mathematics It is the web that holds the enterprise together It is what makes the subject ... What Does a Proof Consist Of? 0.5 The Purpose of Proof 0.6 The Logical Basis for Mathematics 0.7 The Experimental Natureof Mathematics 0.8 The Role of Conjectures ...
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health ofthe public The Institute acts under the responsibility given to the ... as the prospect of new ways of meeting the need, provides the back-drop for the discussions at the 37th Annual Meeting ofthe Institute of Medicine (IOM) Entitled Evidence-Based Medicine and the ... president ofthe National Academy of Sciences The National Academy of Engineering was established in 1964, under the charter ofthe National Academy of Sciences, as a parallel organization of outstanding...
... the location of amyloidogenic mutations and position of b-strands (A) The structure ofthe polypeptide backbone ofthe two chains (purple and blue) is shown along with the location ofthe N-terminus ... tissue and that the distribution of TTR deposition reflects the presence of these endogenous factors In the case ofthe Ab protein of Alzheimer’s disease, a number of proteins and factors (pathological ... these diseases, in particular Alzheimer’s disease, may help to explain some aspects ofthe pathogenesis of FAP The idea is discussed further in the following sections Tissue-specific pattern of...
... described by the Standard Model Other challenges to the Standard Model are posed by the predominance ofmatter over antimatter in the universe, the early evolution ofthe universe, and the discovery ... of electrons and positrons Together, the LHC and an ILC will enable physicists to explore the unification ofthe fundamental forces, probe the origins of mass, uncover the dynamic natureofthe ... be one ofthe first signals ofthe new physics expected in the years ahead, since the observed masses are in the range predicted by theoretical ideas that unify the forces ofnature In the future,...
... loss, within affected cells, ofthe two alleles of a given CCM gene Loss of one ofthe alleles (first hit) would be the result of a germline mutation and loss ofthe second allele (second hit) ... K569E, were detected in the CCM lesion and were shown to be absent in the blood ofthe patient However, the data were difficult to interprete because ofthenatureofthe mutations which were ... occur somatically This hypothesis is not easy to test because ofthe heterogeneous cellular natureof CCM lesions and the very limited number of endothelial cells lining the capillary cavities Indeed,...
... that the advent of quantum physics in the sciences and the rise of modernism in the arts in the early twentieth century represent two facets ofthe same profound shift in the cultural evolution of ... spots The lighter a particular area ofthe image is, the higher the density of random spots, or “events”, the algorithm generates in this area Fig shows the output ofthe program used to create the ... materials or in the mathematical concept ofthe Cartesian grid, but as something more organic The Universe (The Cellular Structure of Space-Time) imagines the smallest units of space-time as the bubbles...
... center of mass and the energy of motion is proportional to the sum ofthe squares ofthe speeds ofthe molecules The observer inside the moving vehicle calculates the gas temperature by measuring the ... can say that the understanding of matter, the development of electricity, and the unveiling ofthe structure ofthe atom have led to the discovery of a new state ofmatter It is more than 100 years ... above encouraged us to write the second edition ofThe Fourth State ofMatterThe aim ofthe second edition is to bring The Fourth State ofMatter up to date in the light of progress Sometimes progress...
... earlier, themolecular identity ofthe protein(s) that actually form the PTP channel remains the most intriguing question On the basis of structural and other information, we hypothesize that the ... increased the conductance of artificial lipid bilayers in the presence of Ca2+, and the conductance was sensitive to ruthenium red [22], implying that it may be the Ca2+ uniporter or part thereof Further ... is driven by the pH gradient, in the case ofthe Ca2+ ⁄ 2H+ exchanger Elevated intramitochondrial Ca2+ can stimulate the activities of enzymes ofthe tricarboxylic acid cycle (TCA), thereby boosting...
... Evolution oftheMolecular Biology of Brain Tumors and the Therapeutic Implications high grade gliomas The structure and compounds ofthe ECM ofthe brain tissue have many specific differences from other ... mortality ofthe patient Moreover, the presence ofthe blood-brain barrier (BBB) limits the passage of a wide variety of anticancer agents The high incidence of recur‐ rence and poor prognosis of malignant ... Hofmann M Characterisation ofthe murine gene encoding the intracellular hyaluronan receptor IHABP (RHAMM) Gene 1999;226:41 23 24 Evolution oftheMolecular Biology of Brain Tumors and the Therapeutic...
... characterized the contribution of these assay components by omitting them individually In the absence of ferredoxin the reaction rate decreased to 46.5% ofthe complete reaction while the absence of ascorbate ... Arrows indicate the direction ofthe major changes in absorption over the course ofthe measurements (C) Michaelis– Menten plot ofthe PsHO1 reaction for heme concentrations of 1, 2, 5, 10 and ... account for the failure ofthe PsHO1 probe to detect any HO2-like sequences in Southern blot experiments Whatever the basis ofthe recovery of phytochrome responses in older pcd1 plants, they still...
... of units, which are inde- natureofthe substance which the electrification is the seat of CHAPTEE II THE ORIGIN OFTHE MASS OFTHE CORPUSCLE The origin ofthe mass ofthe corpuscle is very interesting, ... thus the number of drops will be the volume of for ; the water deposited divided by the volume of one ofthe Hence, if we find the volume of one ofthe drops drops we can find the number the charged ... different rays in the same tube may be these rays is independent different, but the value of e/m for ofthe velocity as well as ofthenatureofthe gas and the electrodes In the case ofthe canalstrahlen...
... thus reflects the actual activity level ofthe patient The presence ofthe physician's assessment ofthe severity ofthe patient's condition here is of interest and leads us to hypothesize if not ... thus the physician perceived urgency of need for TKAR, is based largely on the physician's assessment ofthe individual patient's activity or lack thereof Factor reflects the mental status ofthe ... Ireland Neither of these organizations participated in study design; in the collection, analysis, and interpretation of data; in the writing ofthe manuscript; or in the decision to submit the manuscript...
... that the pathological natureofthe clavicular fracture was appreciated in retrospect To the best of our knowledge, this is the first time that the delay that can be associated with diagnosing the ... above the age of 45 years, multiple recent fractures or pain at the site before the fracture [9] Such patients should also have a thorough physical examination ofthe upper limbs, the rest ofthe ... radiograph ofthe left shoulder taken months later Plain radiograph ofthe left shoulder taken months later The radiograph demonstrates a large lytic lesion (arrow) over the medial aspect ofthe clavicle...