Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease" docx

... to be mediated bytwo distinct domains. In VEGF-A, these correspond to thebasic heparin-binding domain encoded by exon 6 and theNRP1/heparin-binding domain encoded by exons 7 and 8[10]. The ... ligandsfor VEGFR2 and VEGFR3 and are initially synthesized asdisulfide-linked polypeptides containing amino- and carboxy-terminal propeptide extensions not found in otherVEGF proteins, flanking a central ... conditions of low oxygentension as a result of binding of unidentified factors to its 3ЈUTR. VEGF-A gene expression is also upregulated by avariety of growth factors and cytokines, including PDGF-BB,TGF-␤,...

Báo cáo sinh học: "Combined vascular endothelial growth factor-A and fibroblast growth factor 4 gene transfer improves wound healing in diabetic mice" pptx

... Hamani Y, Khudyak V, Ariel I, Yagel S: Vascular endothelial growth factor, epidermal growth factor and fibroblast growth factor- 4 and -10 stimulatetrophoblast plasminogen activator system and metalloproteinase-9. ... [1]. Many factors contribute to chronic, non-healing diabetic wounds, among which crucial is theimpairment in the production of cytokines and growth factors, such as keratinocyte growth factor ... and no significant side effects. In the present study combinatory therapy with VEG F-A and FGF4 coding sequences increased the vascularityof granulation tissue. Concerning vascularity, onlymature...

Báo cáo y học: "The evidence base for chiropractic treatment of musculoskeletal conditions in children and adolescents: The emperor''''s new suit" pdf

... hardly anything to review, turning this intoa very brief report.The reviewType of studiesRandomized, quasi-randomized (allocation subject tobias) and non-randomized clinical studies were includedif ... disorders in children and adolescents.Randomized, quasi-randomized and non-randomized clinical studies were included if they investigated the effect of manual therapy on musculoskeletal disorders in ... authors independently screened the titles and abstracts from the search results. Potentially relevantpapers were obtained in full text and independentlyassessed for inclusion.Qualitative and quantitative...

Báo cáo y học: "Action of fibroblast growth factor-2 on the intervertebral disc" docx

... actively regulatematrix homeostasis through activities modulated by a variety ofstimuli, including cytokines and growth factors acting in aparacrine and/ or autocrine fashion. The cells in the ... understanding of the complex interplay of growth factors, cytokines, and enzymes in the IVD. To our knowledge,this is the first study that demonstrates the pathophysiologiceffects of FGF2 in spine ... IVD homeostasis includepolypeptide growth factors, such as insulin-like growth factor 1, transforming growth factor beta (TGFβ) and the bone mor-phogenetic proteins (BMPs) [7]. In particular,...

Báo cáo y học: "The Impact of a Nationwide Antibiotic Restriction Program on Antibiotic Usage and Resistance against Nosocomial Pathogens in Turkey"

... ones in a study comparing antibiotic utilisation before and after NARP in a single centre from Turkey revealed 125.3% increase in the use of 2nd and 3rd generation oral cephalosporins ... in four year period, which included two years before and after of the initiation of NARP in 2003. The study in- cluded the data obtained from all of the four univer-sity hospitals, and one ... 29. Aypak C, Altunsoy A, Düzgün N. Empiric antibiotic therapy in acute uncomplicated urinary tract infections and fluoroquino-lone resistance: a prospective observational study. Ann Clin Microbiol...

Báo cáo Y học: The cold-active lipase of Pseudomonas fragi Heterologous expression, biochemical characterization and molecular modeling pdf

... ofproline and arginine residues, and hydrophobic coreinteractions are generally recognized as key factors in determining the ﬂexibility of the enzyme molecule and, as aconsequence, its catalytic ... peptide-independent pathway and calls for furtherinvestigation on this subject.Enzyme activity and speciﬁcity In the standard tricaprylin hydrolysis assay, rPFL displayedhighest activity at 29 ... rigidity of the protein backbone and thereforeits thermostability [35]. Interestingly, the only disulphidebridge present in BCL and PAL is missing in the PFL,where only one cysteine residue is present....

Báo cáo Y học: The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei docx

... recombinant protein. The individualdomains A and B were puriﬁed by cobalt-afﬁnitychromatography, and were assayed for cGMP bindingFig. 6. PKI inhibits the activity of coimmunoprecipitating kinase.Immunoprecipitates ... analyzed byimmunoblotting, using an afﬁnity-puriﬁed polyclonalantibody raised against recombinant TbRSU (see Materials and methods). This polyclonal antibody not only recognizesTbRSU in trypanosomes, ... involved in binding and inactivation of the catalytic subunit, and twoC-terminally located, closely spaced cyclic nucleotidebinding domains. Immunoprecipitation of TbRSU copre-cipitates a protein...

Báo cáo y học: "The psychological well-being of children orphaned by AIDS in Cape Town, South Africa" pptx

... Congoleseorphans, and found 20% experiencing psychological dif-ficulties, including depression, anxiety and irritability(34%), fugue, offending and hyperactivity (27%), and PTSD (39%).Studies in the USA In ... thesefindings suggest that children orphaned by AIDS mayhave unmet psychological needs. The finding of strikinglyhigh PTSD-type symptoms in this study indicate that thisshould be a key area ... siblings and increased family size. Volle et al. [23] interviewed 788orphans in Zambia. 89% reported unhappiness, and 19%running away from their new homes. Makaya et al.(2002), used clinical interviews...

Báo cáo y học: "The PI3K–NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis" pdf

... functionality and is accompanied by modulation ofdownstream cell growth regulatory proteins resulting in tumor growth inhibition. In the present study, key signaling proteins in the synovial cells and ... adjuvant-induced arthritis; BSA = bovine serum albumin; DLN = drain lymph node; GSK-3β = glycogen syn-thase kinase-3β; H & E = hematoxylin and eosin; IB-MECA = 1-deoxy-1-(6-{[(3-iodophenyl)methyl]amino}-9H-purine-9-yl)-N-methyl-β-D-ribofura-nuronamide; ... mediating the anti-inflammatoryeffect of adenosine. The highly selective A3AR agonist 1-deoxy-1-(6-{[(3-iodophenyl)methyl]amino}-9H-purine-9-yl)-N-methyl-β-d-ribofuranuronamide (IB-MECA) inhibited...

Báo cáo y học: "Activation of transforming growth factor-β1 and early atherosclerosis in systemic lupus erythematosus" pptx

... adjusting for Fram-ingham risk factors, a significant excess risk remains [25]. Thissuggests that additional factors contribute to atherogenesis in SLE. Additional factors at play in SLE may include ... activation during blood clotting in patients and controlindividuals, and examined whether TGF-β1 activation wasassociated with clinical phenotype, in particular inflammatorydisease activity, cumulative ... resuspended in 1 ml staining buffer (50 µg/ml PI, 0.5µg/ml RNase A, PBS). Samples were incubated at 4°C for 2hours, washed once in PBS, resuspended in PBS and ana-lyzed by flow cytometry. Flow cytometric...

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