... 3University of California Los Angeles Dental Research Institute and University of California Los Angeles School of Dentistry, Los Angeles, California 90095, USA and 4Department of Immunology, ... effective,presumably because of more efficient formation of dou-ble strand siRNA from a hairpin precursor as opposed tokinetic reassociation of sense and antisense followingindependent expression of each. U6 ... presence of A and lack of G,C at position 19.One algorithm (Sfold[26]) predicted an siRNA sequencesimilar to the sequence of CCR5 shRNA (1005), but hav-ing an additional C at the 5' end and...