Essentials of Clinical Research - part 7 ppt

... 2003; 289:1969 75 . 2. Lenfant C. Shattuck lecture clinical research to clinical practice–lost in translation? N Engl J Med 2003; 349:868 74 . 3. Kiefe CI, Sales A. A state -of- the-art conference ... Jan 17, 20 07; 2 97( 3): 278 –285. 63. D’Agostino RB, Jr. Propensity score methods for bias reduction in the comparison of a treat- ment to a non-randomized control group. Stat Med. Oc...

Ngày tải lên: 14/08/2014, 11:20

... use Short-term use of drug Narrowly-specified or restricted population PE-POSTMARKETING Large population of users Long study period Off-label use; new indications Long- term use Hetero- geneous population Exposure ... the adulteration of agricultural commodities was actu- ally initiated as early as 18 67. When Harvey Washington Wiley arrived as chief S.P. Glasser (ed.), Essentials o...

Ngày tải lên: 14/08/2014, 11:20

... 32, 35– 37, 42, 49, 50, 57, 60, 65, 66, 68, 70 73 , 75 , 78 , 80, 81, 84, 90, 103, 104, 106, 1 07, 109, 121, 160, 1 67, 174 , 177 , 178 , 179 , 208, 214, 221–244, 291, 296 rapport 152, 346, 3 47 RCT, ... 308, 3 17, 318 Bayesian logic 250 beta-blocker heart attack trial 132 bias 6, 10, 23, 24, 34, 35, 60, 68, 72 , 76 , 78 , 106, 1 07, 136, 1 47, 163–168, 170 , 172 , 175 , 177 , 1...

Ngày tải lên: 14/08/2014, 11:20

... Chapter 005. Principles of Clinical Pharmacology (Part 7) Renal Disease Renal excretion of parent drug and metabolites is generally accomplished by ... in the elderly because of altered pharmacokinetics and pharmacodynamics, the frequent use of multidrug regimens, and concomitant disease. For example, use of long half-life benzodiazepines ... of lidocaine is reduce...

Ngày tải lên: 06/07/2014, 08:20

... subtype of ALL violates the dogma that cytoplas- mic granules are suggestive of AML. This case is a B-lineage type of ALL with cytoplasmic granules that are peroxi- dase-negative and behave as lyso- somes a ... isolated Lan- ghans giant cells Fig. 138 a, b), and toxoplasmosis (epitheloid-cell lymphadenitis of Piringer-Ku- chinka, see Fig. 136 a – d). In the examination of cervical l...

Ngày tải lên: 10/08/2014, 08:20

... phenotypes Total 11 5 97 685 37 60 12 379 Table 16.2 Entries in the ‘OMIM’ database by chromosomal location Chromo- Loci Chromo- Loci Chromo- Loci some some some 1 689 9 264 17 413 2 428 10 244 18 ... Information, National Institute of Health, USA) 0 5000 10000 15000 20000 25000 30000 35000 1 972 1 974 1 976 1 978 1980 1982 1984 1988 1990 1992 1994 1996 1998 1986 acg-16 11/20/01 7...

Ngày tải lên: 10/08/2014, 14:22

... time. Essentials of Clinical Research Part I This Part addresses traditional clinical research, beginning with the history of the development of clinical research, to traditional clinical research ... description of the randomization process 2 Introduction to Clinical Research and Study Designs 17 comes in. You challenge him to a free throw shooting contest...

Ngày tải lên: 14/08/2014, 11:20

... trials. A clinical trial is one type of clinical research. A clinical trial is a type of experi- mental study undertaken to assess the response of an individual (or in the case of group clinical ... 1995; 273 (18):142 1-1 428. 19. Lang JM. The use of a run-in to enhance compliance. Stat Med. Jan-Feb 1990;9( 1-2 ):8 7- 9 3; discussion 9 3-8 5. 20. Shem S. The House...

Ngày tải lên: 14/08/2014, 11:20

... Project Research Group 73 planned to evaluate the efficacy and safety of several lipid-influencing drugs in the long-term treatment of coronary heart disease. This randomized, double-blind, pla- cebo-controlled, ... Modernization Act of 19 97. In: Department of Health and Human Services FaDA, ed. Vol 21 U.S.C. 352(a). 37. Baylor-Henry M, Drezin N. Regulation of prescription d...

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... meta-analysis Raw data Treatment A PLACEBO Study Total no. of patients No. dead No. alive Total no. of patients No. dead No. alive 1 615 49 566 624 67 5 57 2 75 8 44 71 4 77 1 64 70 7 3 3 17 27 290 ... number 7 above. One limited type of meta-analysis, and a way to overcome some of the limita- tions of meta-analysis in general, is to preplan them with the prospective reg...

Ngày tải lên: 14/08/2014, 11:20