general principles of clinical pharmacology ppt

... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5- 2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... a Inhibitors affect the molecular pathway, and thus may affect substrate. b Clinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

... basic principles of clinical phar- macology currently are being applied in the process of drug development. Journals Clinical Pharmacology and Therapeutics British Journal of Clinical Pharmacology Journal ... effective use of medicine can be traced back at least to Rudolph Bucheim (1820–1879), who has been credited with 1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION 20 Principles of Clinical Pharmacology Therefore, ... 6 Principles of Clinical Pharmacology TABLE 1.1 Status of Renal Function in 44 Patients with Digoxin Toxicity a Serum creatinine (mg/dL) No. of patients with CL CR of Percentage of group 50...

Ngày tải lên: 22/03/2014, 23:20

... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...

Ngày tải lên: 06/07/2014, 08:20

... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than- normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... prevent elimination by very rapid (t 1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

Ngày tải lên: 06/07/2014, 08:20

... Constitutionalism: The Rule of Law and the Separation of Powers 92 5.1 Introduction: The Nature and Purpose of the Rule of Law 92 5.2 The Core Meaning of the Rule of Law 94 5.3 The Extended Rule of Law 95 5.4 ... The aims of this edition remain the same as those of previous editions: namely, to explain and discuss critically the general principles of the constitutional law and administrative law of the ... Extended Rule of Law 95 5.4 Dicey’s Version of the Rule of Law 97 5.5 The International Rule of Law 101 5.6 Dissent and the Rule of Law 104 5.7 The Separation of Powers 105 Summary 118 Further Reading...

Ngày tải lên: 18/02/2014, 05:20

... 30-Jan Interviews, a preparation for Speech of Introduction A, J 2-Feb SPEECH OF INTRODUCTION S, F 4-Feb SPEECH OF INTRODUCTION S, F 6-Feb SPEECH OF INTRODUCTION S, F, J 9-Feb Organizing the ... incorporate each of the previous speaking purposes, with the additional task of cooperating in a team of approximately 4 to craft an extended presentation (no more than 45 minutes) on a topic of your ... outside of our class and write a thoughtful critique of the speaker. In 2-3 pages, you should discuss topics such as the strengths and limitations of the speaker’s style, organization of content,...

Ngày tải lên: 20/12/2013, 23:15

... Part Two Annotations to the OECD Principles of Corporate Governance 9 © OECD 2004 OECD Principles of Corporate Governance The OECD Principles of Corporate Governance were originally ... board, subject to the approval of the shareholders. Some companies issue preferred (or preference) shares which have a preference in respect of receipt of the profits of the firm but which normally ... support the exercise of entrepreneurship and limit the risks of damaging conflicts of interest in both the private sector and in public institutions. OECD PRINCIPLES OF CORPORATE GOVERNANCE...

Ngày tải lên: 16/01/2014, 16:33

... 92-64-01597-3 26 2004 02 1 P OECD Principles of Corporate Governance OECD Principles of Corporate Governance Since they were issued in 1999, the OECD Principles of Corporate Governance have gained ... corporate officers may not only violate the rights of stakeholders but also be to the detriment of the company and its shareholders in terms of reputation effects and an increasing risk of future ... board. Each of the sections is headed by a single Principle that appears in bold italics and is followed by a number of supporting sub -principles. In the second part of the document, the Principles...

Ngày tải lên: 26/01/2014, 12:20

... of income, in- cluding compensation of employees, corporate profits, and so on. A slice of the pie represents each source’s share of the total. The bar graph in panel (b) compares a measure of ... I’ll produce 24 pounds of meat and 2 pounds of potatoes. After I give you 3 pounds of meat in exchange for 1 pound of potatoes, I’ll have 21 pounds of meat and 3 pounds of potatoes. In the end, ... less of the other. When the economy moves from point A to point C, for instance, society produces more computers but at the ex- pense of producing fewer cars. Another of the Ten Principles of Economics...

Ngày tải lên: 05/03/2014, 20:20