Báo cáo y học: "A mathematical model of the euglycemic hyperinsulinemic clamp" ppsx

... interested in, whether the speed or the capacity of response. The case of the obese subject represents this ambiguity very well: if by insulin resistance we mean the result of the EHC at 2 hours, ... sensitivity in this patient group. While the observed lack of significance may well be a conse- quence of the limited power of the present study, given the small n...

Ngày tải lên: 13/08/2014, 23:20

... 8:8 http://www.tbiomed.com/content/8/1/8 Page 29 of 29 not be exceeded. The latter effect is of the type of a superdiffusion singularity, the for- mer of the type of the porous medium equation degeneracy. The diffusion coefficients ... remains largely unanswered. We expand on the works of [38-40,42]. Study [42] analyzes the effectiv eness of the modelled anti-q...

Ngày tải lên: 13/08/2014, 16:20

... further treatment or surgery [1,2]. The data analy- sis of the Dialysis Outcomes Quality Initiative panel [2,3] suggests a primary patency of 85% for AV fistulas at one year and 75% at two years, ... by synthetic ePTFE graft. Pathogenesis of venous neointimal hyperplasia (VNH) The most important events initiating the pathogenesis of VNH are: (a) surgical injury at the time...

Ngày tải lên: 13/08/2014, 16:21

... over protein synthesis. Thus the availability of cysteine and the activity of GCS are the major determinants of GSH synthe- sis. The enzyme cystathionine-β-synthase (CBS) that cata- lyzes the first ... [28-30]. The third factor in the following formula is the activation of GCS by H 2 O 2 [25,26]. The second step in the synthesis of GSH is the addition of th...

Ngày tải lên: 13/08/2014, 16:21

... γ- phosphoryl groups of GTP, the other with the aspartate in the enzyme's active center, improving the affinity of the enzyme for ASP. Kinetic experiments on the interactions of Mg 2+ and ... biochemical data on the reaction mechanism, at least two alternative hypotheses could be put forward. We checked whether these hypotheses were consistent with the kinetic data...

Ngày tải lên: 13/08/2014, 16:21

... in the previous model, the volume of the ER is assumed to be 1/20 of the volume of the cytosol. CAC is deter- mined by the rate of calcium efflux through ion channels in the ER membrane minus the ... Thus, in the present study, we limit the time of exposure to three hours. We also ignore the long term effects of diacylglycerol which is known to cause an incr...

Ngày tải lên: 13/08/2014, 22:22

... Holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) 47 D00943 MYH6 Myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic ... test the validity of the array data by examining a physiologic mechanism implicated by computer modelling of the array data. As noted in Table 1, adult monocytes over-expressed a small num...

Ngày tải lên: 11/08/2014, 08:21

... build on the fundamen- tal knowledge that the risk of disease transmission is not only a function of the infectivity of the infectious agent and the quality of the immune response but also of the host's ... single contact partner. Additionally, most people plausibly have only a very limited set of persons with whom they interact very closely. Additionally, the...

Ngày tải lên: 13/08/2014, 16:20

... this hypothesis is the log-likelihood ratio (LR) of the reduced to the full model, i.e., where the tildes and hats denote the MLEs of the unknown parameters under the H 0 and H 1 , respectively. AA ... null hypothesis states that there is no QTL affecting the clonal expansion of the cells (the reduced model) , whereas the alternative states that such a QTL does e...

Ngày tải lên: 13/08/2014, 16:21

... (TIR) genes pathway analysis. To determine the putative biological role of the TIR genes, the expression data were analyzed through the use of Ingenuity Pathway Analysis. The top ranking module ... supported by the type 1 diabetes (TID) research community. [http://www.t1dbase.org]. 29. Marsin AS, Bouzin C, Bertrand L, Hue L: The stimulation of glycolysis by hypoxia in acti...

Ngày tải lên: 13/08/2014, 21:21