... Nakamura K, Tokunaga Y, Hanada S, Kumemura H, Maeyama M, Harada M, Ogata H, YanoH, Kojiro M, Ueno T, Yoshimura A, Sata M: Spreds, inhibitors ofthe Ras/ERK signal transduction, are dysregulated ... strains.DiscussionRA histology is typically characterized by pronounced synovialhyperplasia, also called 'pannus'. The RA pannus producesproinflammatory cytokines and proteases, and invades carti-lage ... expression analysiswas conducted to identify genes and pathways that are differ-entially expressed between highly invasive DA and minimallyinvasive DA.F344(Cia5d) FLSs. The analysis revealed that...