Harper’s Illustrated Biochemistry - Part 7 ppsx
Harper’s Illustrated Biochemistry - Part 7 ppsx
... ENZYME
ANGIOTENSINASES
Asp-Arg-Val-Tyr-
I
le-His-Pro-Phe-His-Leu-Leu (~400 more amino acids)
Asp-Arg-Val-Tyr-
I
le-His-Pro-Phe-His-Leu
Asp-Arg-Val-Tyr-
I
le-His-Pro-Phe
Arg-Val-Tyr-
I
le-His-Pro-Phe
Figure ... α-Hydroxylase24-Hydroxylase
HO
HO
27
25
24
26
HO
CH
2
CH
2
OH
OH
7- Dehydrocholesterol
1,25(OH)
2
-D
3
24,25(OH)
2
-D
3
1,24,25(OH)
3
-D
3
25-Hydroxycholecalciferol (25[OH]-D
3
)
1,...
Harper’s Illustrated Biochemistry - Part 2 pptx
...
hemolymph.
1
O- -
D
-Glucopyranosyl-(1 → 1 )- -
D
-glucopyranoside.
HO
H
HOCH
2
H
OH
H
H
OH
O
H
O- -
D-Glucopyranosyl-(1 → 4 )- -D-glucopyranose
O- -
D-Glucopyranosyl-(1 → 2 )- -D-fructofuranoside
3
5
6
4
H
HOCH
2
H
OH
H
H
OH
O
OH
H
5
6
4
O
Maltose
**
11
232
HO
H
HOCH
2
H
OH
H
H
OH
O
H
3
5
6
4
O
Sucrose
1
2
*
HOCH
2
1
O
OH ... +
⋅
+
Substrate A-H
A-OH
P450-A-H
Fe
3
+
P450
F...
Harper’s Illustrated Biochemistry - Part 3 pdf
... (6-phospho-
fructo-2-kinase/fructose-2,6-bisphosphatase). (PFK-1,
phosphofructokinase-1 [6-phosphofructo-1-kinase];
F-1,6-Pase, fructose-1,6-bisphosphatase. Arrows with
wavy shafts indicate allosteric effects.)
fructose-1,6-bisphosphatase. ... 6-phosphate
H
2
O
P
i
GLUCONEOGENESIS
GLYCOLYSIS
Glycogen
Glucose
Pyruvate
Citrate
F-1,6-Pase
PROTEIN
PHOSPHATASE-2
Inactive
F-2,6-Pase
Active
PFK-2
A...
Harper’s Illustrated Biochemistry - Part 5 pptx
... 2 97
HN
2
H
7
5
Formylglycinamidin
e
ribosyl-5-phosphate
R- 5-
P
(VI)
3
6
ATP, Mg
H
2
O
H
2
O
H
2
O
2
+
Ring closure
7
R- 5-
P
Aminoimidazole
ribosyl-5-phosphate
(VII)
N
2
H
8
OOC
CO
2
C
CH
R- 5-
P
2
H
N
N
Aminoimidazole
carboxylate ... is
D
-ribose, and in deoxyribonucleo-
sides it is 2-deoxy-
D
-ribose. The sugar is linked to the
heterocyclic base via a -N-glycosidic bond, a...
Harper’s Illustrated Biochemistry - Part 6 potx
... properties.
ch 37. qxd 3/16/04 11:02 AM Page 355
386 / CHAPTER 39
HMGI-Y
ATF-2
cJun
NF-κB
IRF(IRF3 /7)
HMG
PRDIV PRDII NRDI
HMG HMG HMG
PRDI-III
IRF3
HMGI
HMGI
HMGI
HMGI
ATF-2
cJun
IRF7
NF-κB
Figure ... the in-
creased number of subunits, eukaryotic pol II differs
from its prokaryotic counterpart in that it has a series of
heptad repeats with consensus sequence Tyr-Ser-Pro-
Thr-Ser-Pro-Ser a...
Harper’s Illustrated Biochemistry - Part 9 pps
... proteins” (or re-
actants) and include C-reactive protein (CRP, so-named
because it reacts with the C polysaccharide of pneumo-
cocci), α
1
-antitrypsin, haptoglobin, α
1
-acid glycopro-
tein, and ... form “arrowheads.”
(Courtesy of JA Spudich.)
ATP-Myosin
ADP-P
i
-Myosin
Actin
H
2
O
Actin
ATP
ADP
+
P
i
Actin-Myosin
Actin-Myosin
ADP-P
i
Actin-Myosin
ATP
1
2
3
4
5
Figure 49–6. The hydrolysis ....
Harper’s Illustrated Biochemistry Twenty-Eighth Edition_2 docx
... hydrolases, including α-neuraminidase,
β-galactosidase, β-hexosaminidase, - and β-mannosidases,
α-N-acetylgalactosaminidase, α-fucosidase, endo- β-N-acetyl-
glucosaminidase, and aspartylglucosaminidase. ... using
Dol-P-Man as the donor. Dol-P-Man is formed by the
following reaction:
Dol-P + GDP-Man → Dol-P-Man + GDP
4. Finally, the three peripheral glucose residues are
donated by Dol-...
Harper’s Illustrated Biochemistry Twenty-Eighth Edition_1 ppt
... well-ordered crystals. To establish appropriate
Forkhead transcription factor
DNA-bindingNLS Pr-Pr
6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase
Reg
RegCatalysis
Pr-Pr
RegCatalysis
Pr-Pr
Pr-Pr
Catalysis
Catalysis
Phenylalanine ... hydrolyze pep-
tide bonds and generate peptides with as few as two or three
amino acids. Each peptide was reacted with 1- uoro-2,4-dini-
IEF
SDS
PAGE
01=...
harper's illustrated biochemistry - robert k. murray, darryl k. granner, peter a. mayes, victor w. rodwell
... Cleaved
CNBr Met-X
Trypsin Lys-X and Arg-X
Chymotrypsin Hydrophobic amino acid-X
Endoproteinase Lys-C Lys-X
Endoproteinase Arg-C Arg-X
Endoproteinase Asp-N X-Asp
V8 protease Glu-X, particularly ... terminal aminoacyl residue. For example, Lys-
Leu-Tyr-Gln is called lysyl-leucyl-tyrosyl-glutamine.
The -ine ending on glutamine indicates that its α-car-
boxyl group is not involved in peptide bon...
