Báo cáo y học: " Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury" pot

... present in the intestinal lumen. This hypothesis is supported by positioning of iNOS on the apical side of intestinal crypts. Recently PDZ-binding a 2 ⁄ b 1 -NO-sensitive guanylate cyclase [29] ... (iNOS) protein is responsible for sustained release of nitric oxide (NO) and is typically synthesized in response to proinflam- matory stimuli [1]. iNOS protein is induced in a large...

Ngày tải lên: 19/02/2014, 16:20

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Ngày tải lên: 07/08/2014, 15:20

... production of several proinflamma- tory cytokines (IL-6, IL-8 and GM-CSF) and VEGF in RA- FLS. Since they were suppressed by an EGFR tyrosine kinase inhibitor, the AREG-dependent induction of these cytokines ... by ELISAs. The proinflammatory roles were assessed by the growth-promoting and cytokine-inducing effects of the corresponding recombinant proteins on cultured fibroblast-lik...

Ngày tải lên: 11/08/2014, 08:21

... Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme for PAA and derivatives thereof, while maintaining the ... phenylglycyl- and p-hydroxyphe- nylglycyl-enzyme of bF24A, as indicated by, respectively, a twofold and fourfold increased V s /V h ratiocomparedtothe wild-type (Table 4). The V s /V h r...

Ngày tải lên: 17/03/2014, 23:20

... Bersselaar L, Van den Berg WB: Reduction of interleukin-17-induced inhibi- tion of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4. Arthritis Rheum 2000, 43: 1300-1306. 46. ... induction of metalloproteinases by IL-17 in synoviocytes and chondrocytes [48–50]. Interestingly, the IL-17 family subtypes IL-17F and IL-17E also showed cartilage des...

Ngày tải lên: 09/08/2014, 06:22

... to interfere with the inflammatory response in SLE by adminis- tering only an induction regime of four infusions of infliximab within 10 weeks rather than by planning for long-term therapy. Evidence ... appears to play a major pro-inflammatory role in SLE also. The available open-label experience on infliximab therapy in SLE suggests that, in combination with azathioprine, infli...

Ngày tải lên: 09/08/2014, 10:22

... pro-inflammatory cytokine that is produced in response to injury, exerting a number of important roles in the immune system and during inflammatory responses. It is of particular interest in neuropathology ... con- sequences in each case may enhance the inflammatory response and the clearance of infection in acute infection, but have potentially deleterious effects in chro...

Ngày tải lên: 11/08/2014, 08:21

... VEGF in the lung induces pulmonary edema with increased lung vascular permeability, the role of VEGF in the development of acute lung injury remains to be determined. Methods: To evaluate the role ... role of VEGF in the pathogenesis of acute lung injury, we first evaluated the effects of exogenous VEGF and VEGF blockade using monoclonal antibody on LPS-induc...

Ngày tải lên: 12/08/2014, 15:21

... joint involvement and rapid joint progression confirm observations that the frequency of CD4 + CD28 – T cells may correlate with the risk of occurrence of joint erosions in RA [18]. Competing interests None ... protein Bcl-2 and Fas-associ- ated with death domain-like IL-1-converting enzyme inhibitory protein (FLIP) [16]. The absence of CTLA4 surface expression on CD28 – T cells may...

Ngày tải lên: 09/08/2014, 01:22

... University, Husargatan 3, SE-751 21 Uppsala, Sweden. § Key Laboratory of Zoonosis, Ministry of Education, Jilin University, Xi An Da Lu 5333, Changchun 130062, China. ¶ Laboratory of Parasitology, ... are known to interact with the host immune system [12]. These include the family of P. falciparum erythrocyte membrane protein 1 (PfEMP1) proteins, employed by the parasite to seques...

Ngày tải lên: 09/08/2014, 20:20