carboxyl terminal pdz ligand of neuronal nitric oxide synthase
Báo cáo khoa học: Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase pptx
... this type of structure is also adopted by Ca2+-CaM when it binds to the CaM-binding domain of endothelial nitric oxide synthase (eNOS) [33] The second example is when the C -terminal lobe of Ca2+-CaM ... formation of NO by neuronal nitric oxide synthase (nNOS) [10] These particular amphibian peptides (e.g the caerins and splendipherin [11]), are basic and hinged, and inhibit the operation of nNOS ... that of Ca2+-CaM [10,11,25,26], and therefore adversely affects binding of CaM to the Ca2+-CaM-binding domain of nNOS CaM is not only essential for the operation of nNOS and the other NOS isoforms,...
Ngày tải lên: 23/03/2014, 09:21
Báo cáo khoa học: Thermodynamic and kinetic analysis of the isolated FAD domain of rat neuronal nitric oxide synthase altered in the region of the FAD shielding residue Phe1395 docx
... analysis of the flavin cofactors of neuronal nitric oxide synthase Biochemistry 38, 16413–16418 Wolthers, K.R., Basran, J., Munro, A.W & Scrutton, N.S (2003) Molecular dissection of human methionine synthase ... FAD isoalloxazine ring nNOS, rat neuronal nitric oxide synthase; eNOS, rat endothelial nitric oxide synthase; iNOS, rat inducible nitric oxide synthase; CPR, human cytochrome P450 reductase; NR1, ... Nitric Oxide Synthases Annu Rev Pharmacol Toxicol 37, 339–359 Marletta, M.A (1993) Nitric- oxide synthase structure and mechanism J Biol Chem 268, 12231–12234 Bredt, D.S & Snyder, S.H (1994) Nitric...
Ngày tải lên: 30/03/2014, 14:20
Báo cáo Y học: Amphibian peptides that inhibit neuronal nitric oxide synthase The isolation of lesueurin from the skin secretion of the Australian Stony Creek Frog Litoria lesueuri docx
... three-dimensional structures of certain domains of nitric oxide synthase isoforms are known [53±57], we are not aware of the three-dimensional structure of the calmodulin binding sites of any isoform being reported ... comparison of the calmodulinbinding domains of nitric oxide synthases J.Biol Chem 271, 6435±6440 43 Lee, S.J & Stull, J.T (1998) Calmodulin-dependent regulation of inducible and neuronal nitric oxide synthase ... extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide Nat Struct Biol 6, 417±421 58 Moore, P & Handy, R (1997) Selective inhibitors of neuronal nitric oxide synthase...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps
... DY: Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications Nitric Oxide 2009, 20:223-230 Xu Y, Krukoff TL: Adrenomedullin stimulates nitric oxide ... effects of nitric oxide on baroreflex activation in the brainstem nuclei of rats Chin J Physiol 1996, 39:57-62 26 Pontieri V, Venezuela MK, Scavone C, Michelini LC: Role of endogenous nitric oxide ... endothelial and neuronal nitric oxide synthase in the nucleus tractus solitarii Brain Res 2007, 1171:42-51 28 Tai MH, Weng WT, Lo WC, Chan JY, Lin CJ, Lam HC, Tseng CJ: Role of nitric oxide in alpha-melanocyte-stimulating...
Ngày tải lên: 10/08/2014, 05:21
Tài liệu Báo cáo khoa học: Polarized distribution of inducible nitric oxide synthase regulates activity in intestinal epithelial cells pdf
... Decreased activity of inducible nitric oxide synthase type and modulation of the expression of glutathione S-transferase alpha, bcl-2, and metallothioneins during the differentiation of CaCo-2 cells ... assembly of inducible NO synthase into an active dimer J Biol Chem 274, 930–938 Kuncewicz T, Balakrishnan P, Snuggs MB & Kone BC (2001) Specific association of nitric oxide synthase- 2 with Rac isoforms ... subcellular distribution of the human inducible nitric oxide synthase in an intestinal cell line: evidence for post-translational regulation In The Biology of Nitric Oxide Part 7, (Moncada S,...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Space, time and nitric oxide – neuronal nitric oxide synthase generates signal pulses pptx
... profiles of nitric- oxide synthases I, II, and III J Biol Chem 276, 48887–48898 Nishimura JS et al (1999) The stimulatory effects of Hofmeister ions on the activities of neuronal nitricoxide synthase: ... (1997) A tutorial on the diffusibility and reactivity of free nitric oxide Nitric Oxide 1, 18–30 Salerno JC (2008) Neuronal nitric oxide synthase: prototype for pulsed enzymology FEBS Lett 582, ... density of dendritic spines PLoS ONE 30, 42 Ghosh DK, Holliday MA, Thomas C, Weinberg JB, Smith SM & Salerno JC (2006) Nitric- oxide synthase output state Design and properties of nitric- oxide synthase...
Ngày tải lên: 07/03/2014, 00:20
Báo cáo y học: "Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes" pps
... Abramson SB: The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: evidence for up regulated neuronal nitric oxide synthase J Exp Med 1995, 182:2097-102 ... was representative of three experiments GAPDH, glyceraldehyde-3-phosphate dehydrogenase; iNOS, inducible nitric oxide synthase; JNK, c-Jun amino -terminal kinase; NO, nitric oxide; OCP, octacalcium ... induction of nitric oxide synthase by interleukin-1β in rat glomerular mesangial cells J Biol Chem 1999, 274:36200-36206 69 Taylor BS, Geller DA: Molecular regulation of the human inducible nitric oxide...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: " Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice" potx
... effects of overexpression of one of the NOS isoforms on the development of asthmatic features Furthermore, although the importance of iNOS in asthma is well established [30,34], the precise role of ... Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase J Immunol 1999, 162:445-452 Lee YC, Cheon KT, Lee HB, Kim W, Rhee YK, Kim DS: Gene polymorphisms of endothelial nitric oxide ... Mistretta A, Nadel JA, Sapienza MA, Bellofiore S, Di Maria GU: Randomised double-blind placebo-controlled study of the effect of inhibition of nitric oxide synthesis in bradykinin-induced asthma...
Ngày tải lên: 12/08/2014, 16:20
Báo cáo y học: " Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury" pot
... cytotoxic potential of superoxide and nitric oxide Arch Biochem Biophys 1991, 288:481-487 Lyons CR: The role of nitric oxide in inflammation Adv Immunol 1995, 60:323-371 Page of (page number not ... characterization of nitric oxide synthase isoforms reveals striking active-site conservation Nat Struct Biol 1999, 6:233-242 Schulz C, Gillissen A, Schultze-Werninghaus G: Inducible nitric oxide synthase ... lungs: role of inducible nitric oxide synthase Toxicol Appl Pharmacol 2002, 181:93-105 Dorger M, Allmeling AM, Kiefmann R, Schropp A, Krombach F: Dual role of inducible nitric oxide synthase in...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo y học: " Inhibition or knock out of Inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury" potx
... vitro In addition to ROS, an overproduction of nitric oxide (NO) due to the expression of the inducible isoform of NO synthase (iNOS) also plays Page 10 of 17 (page number not for citation purposes) ... lacking inducible nitric oxide synthase Nature 1995, 375:408-11 El-Khatib AS: Possible modulatory role of nitric oxide in lung toxicity induced in rats by chronic administration of bleomycin Chemotherap ... C: Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation Free Rad Biol...
Ngày tải lên: 12/08/2014, 18:21
Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... constitutively express neuronal nitric oxide synthase mRNA Nitric Oxide 1998, 2, 203-212 Hooper, D.C., Ohnishi, S.T., Kean, R., Numagami, Y., Dietzschold, B and Koprowski, H Local nitric oxide production ... expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis J Vet Sci., 2000, 1, 11-17 11 Moncada, S., Palmer, R.M.J and Higgs, E.A Nitric oxide: physiology, ... Magnification A and B, ×66 C and D, ×132 Immunohistochmical study of nitric oxide synthase in the central nervous system of goat Enhanced expression of nNOS and iNOS in L monocytogenes-infected brain At...
Ngày tải lên: 07/08/2014, 14:23
Tài liệu Báo cáo khoa học: Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain pdf
... calcium-regulated isoforms of nitric oxide synthase J Biol Chem 272, 29769–29777 Daff S, Sagami I & Shimizu T (1999) The 42-amino acid insert in the FMN domain of neuronal nitricoxide synthase exerts ... regulation of neuronal nitric oxide synthase by specific regions of its C -terminal tail Biochemistry 46, 14418–14428 Knudsen GM, Nishida CR, Mooney SD & Ortiz de Montellano PR (2003) Nitric- oxide synthase ... activation of neuronal nitric- oxide synthase J Biol Chem 275, 5052–5058 Roman LJ, Miller RT, de La Garza MA, Kim JJ & Masters BSS (2000) The C-terminus of mouse macrophage inducible nitric- oxide synthase...
Ngày tải lên: 18/02/2014, 11:20
Báo cáo khoa học: Binding and activation of nitric oxide synthase isozymes by calmodulin EF hand pairs potx
... modulation of nitric oxide synthase activity Chem Rev 120, 32047–32050 Abu-Soud HM, Yoho LL & Stuehr DJ (1994) Calmodulin controls neuronal nitric- oxide synthase by a dual mechanism Activation of intra- ... (1997) Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase Biochemistry 36, 12337–12345 11 Ghosh DK & Salerno JC (2003) Nitric oxide synthases: domain structure ... surprising as nCaM only consists of the N -terminal EF hand pair with no central linker region The requirement of the N -terminal EF hand pair of CaM for activation of •NO production by iNOS suggests...
Ngày tải lên: 16/03/2014, 13:20
Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx
... substrates for nitric oxide synthases Bioorg Med Chem 10, 3049–3055 Jia Q, Cai T, Huang M, Li H, Xian M, Poulos TL & Wang PG (2003) Isoform-selective substrates of nitric oxide synthase J Med ... binding of arginine analogs to nitric oxide synthases Nitric Oxide Biol Chem 5, 442–452 13 Ghosh S, Wolan D, Adak S, Crane BR, Kwon NS, Tainer JA, Getzoff ED & Stuehr DJ (1999) Mutational analysis of ... expression of functional rat neuronal nitric oxide synthase in Escherichia coli Proc Natl Acad Sci USA 92, 8428–8432 Chen PF, Tsai AL, Berka V & Wu KK (1996) Endothelial nitric- oxide synthase Evidence...
Ngày tải lên: 16/03/2014, 22:20
Báo cáo khoa học: Rapamycin inhibits lipopolysaccharide induction of granulocyte-colony stimulating factor and inducible nitric oxide synthase expression in macrophages by reducing the levels of octamer-binding factor-2 doc
... Regulation of the expression of inducible nitric oxide synthase Biol Chem 384, 1343–1364 10 Kleinert H, Pautz A, Linker K & Schwarz PM (2004) Regulation of the expression of inducible nitric oxide synthase ... (2000) Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production ... lipopolysaccharidestimulated nitric oxide production in macrophages via interferon-beta J Leukoc Biol 67, 405–414 Xie Q (1997) A novel lipopolysaccharide-response element contributes to induction of nitric oxide synthase...
Ngày tải lên: 22/03/2014, 17:20
Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
... Ubiquitination of neuronal nitric- oxide synthase in vitro and in vivo J Biol Chem 275, 17407–17411 Hajimohammadreza I, Raser KJ, Nath R, Nadimpalli R, Scott M & Wang KKW (1997) Neuronal nitric oxide synthase ... Degradation of NOS isozymes by calpain 44 Araujo IM, Ambrosio AF, Leal EC, Santos PF, Carvalho AP & Carvalho CM (2003) Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide ... binding and activation of apo -neuronal nitric- oxide synthase J Biol Chem 277, 20504–20509 Minami Y, Kimura Y, Kawasaki H, Suzuki K & Yahara I (1994) The carboxy -terminal region of mammalian HSP90...
Ngày tải lên: 23/03/2014, 07:20
Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... activation of apo -neuronal nitric- oxide synthase J Biol Chem 277, 20504–20509 11 Dunbar AY, Kamada Y, Jenkins GJ, Lowe ER, Billecke SS & Osawa Y (2004) Ubiquitination and degradation of neuronal nitric- oxide ... University of Genoa References Kone BC, Kuncewicz T, Zhang W & Yu Z (2003) Protein interaction with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide ... degradation of nitric oxide synthase: effect of inhibitors and role of HSP90-based chaperones J Pharmacol Exp Ther 304, 493–497 13 Govers R, de Bree P & Rabelink TJ (2003) Involvement of the proteasome...
Ngày tải lên: 30/03/2014, 04:20
báo cáo hóa học: " Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells" pptx
... iNOS, inducible nitric oxide synthase; MAPK, mitogen activated protein kinase; NF-κB, nuclear factor kappa B; NGF, nerve growth factor; NO, nitric oxide; nNOS, neuronal nitric oxide synthase; NTR, ... Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate: Involvement of glutamate induced nitric oxide in motor neuron toxicity and nonmotor neuron protection Annals of ... cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells Diabetologia 1998, 41:1101-8 Kong GY, Peng ZC, Costanzo C, Kristensson K, Bentivoglio M: Inducible nitric oxide synthase...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo khoa học: "Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis" pdf
... of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomelitis 27 28 29 30 31 32 33 34 35 36 37 38 Induction of nitric oxide synthase activity in human astrocytes ... Fujimura, H and Yanagihara, T Nitric oxide via an inducible isoform of nitric oxide synthase is a possible factor to eliminate inflammatory cells from the central nervous system of mice with experimental ... Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis J Immunol 1997, 158(6), 2940-2946 Buisson, A., Plotkine, M and Boulu, R G The neuroprotective effect of nitric...
Ngày tải lên: 07/08/2014, 14:22