Báo cáo y học: " Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease" potx

... Synarc, Inc. (Portland, OR). The efficacy and safety analyses were based on all randomized subjects (intent-to-treat population). A confirmatory analysis of subjects who met key eligibility and evaluability ... 80% adherence in recording diary data between screening and baseline. Study design This was a randomized double-blind, placebo-con- trolled, parallel-group study in mal...

Ngày tải lên: 12/08/2014, 14:20

... (dehydro- genation, hydroxylation, and N-dealkylation), mainly by cytochrome P450 2D6 (CYP2D6) and cytochrome P450 3A4 (CYP3A4) [60]. The parenteral drug is excreted only in traces. There is only ... Pharmacokinetics and tolerability of intra- muscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia. Clin Pharmacokinet 2008, 47:475-4...

Ngày tải lên: 08/08/2014, 23:21

... current smoking, rela- tionship to any study personnel, and administration of any investigational drug or participation in any other clinical trial within 4 weeks of entry into our study. All co-existent ... Eccles et al.: Efficacy and safety of an antiviral Iota- Carrageenan nasal spray: a randomized, double-blind, placebo- controlled exploratory study in volunteers with ea...

Ngày tải lên: 12/08/2014, 11:22

... Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease. Respiratory Research 2011 12:55. Submit your next manuscript to BioMed Central and take full advantage of: ... Lamarca R, Garcia GE, Ferrer P: Safety and pharmacokinetics of single doses of aclidinium bromide, a novel long-acting, inhaled antimuscarinic, in healthy subject...

Ngày tải lên: 12/08/2014, 13:22

... Committee of the BTS. Thorax 1997, 52(suppl 5):S1-S28. 2. Chronic Obstructive Pulmonary Disease: Management of Chronic Obstructive Pulmonary Disease in Adults in Primary and Secondary Care. NICE Clinical ... Boehringer Ingelheim and Pfizer. References 1. British Thoracic Society: BTS guidelines for the management of chronic obstructive pulmonary disease. The CO...

Ngày tải lên: 12/08/2014, 15:20

... Antonelli 4 and Jeremy C Wyatt 5 1 Department of Pulmonology, Faculty of Medicine, University of Porto, Portugal 2 Department of Biostatistics and Medical Informatics, Faculty of Medicine, University of ... to understand. The aim of our study was to systematically review the evidence in order to answer key clinical questions about the efficacy and safety of CPAP...

Ngày tải lên: 12/08/2014, 23:23

... College of Rheumatology; AS: ankylosing spondylitis; ASAS: Assessment of SpondyloArthritis International Society; BASDAI: Bath Ankylos- ing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing ... Ankylosing SpOnDYlitis (RHAPSODY) and SafeTy and Efficacy of Adalimumab in Patients with Active Psoriatic Arthritis (PsA): An Open- Label, Multinational Study to Evaluate the R...

Ngày tải lên: 12/08/2014, 14:22

... over-distension and cyclic inflation and deflation of alveoli can damage the alveolar–capillary barrier and initiate or amplify a local and systemic inflammation, so the concept of ventilator-induced lung injury ... (Modena), Italy) and treatment was started. No changes in ventilatory setting were made during the treatment. A bolus of 2,000 UI of heparin was administered i...

Ngày tải lên: 13/08/2014, 03:20

... (as defined in each study), and the remaining 3 % had inde- terminate biochemical findings. Methodological quality There were no randomized or non-randomized con- trolled trials of effusion drainage. ... 14 of 14 Table 1 Summary of studies included in the systematic review (Continued) Ahmed 2004 [33] Measure effects of thoracentesis on hemodynamic and pulmonary physiology Si...

Ngày tải lên: 14/08/2014, 07:21

... histidine. The serine/threonine protein phosphatases type 1, t ype 2 A a nd type 2C, in contrast, a re highly active against phosphohistidine in histone H4 (reviewed in [1]). Intriguingly, none of ... appearance and disappearance of phos- phohistidine on P-selectin are very rapid. The next finding of an intracellular signaling system involving histidine phosphorylation in mamma...

Ngày tải lên: 24/03/2014, 03:21