Báo cáo y học: " Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation" pps

... 2009, 183(4):2758-2766. doi:10.1186/1465-9921-12 -39 Cite this article as: Nikota et al.: Differential expression and function of breast regression protein 39 (BRP -39) in murine models of subacute cigarette smoke exposure and allergic airway ... Access Differential expression and function of breast regression protein 39 (BRP -39) in...

Ngày tải lên: 12/08/2014, 13:22

... Sun K, Myatt L: Enhancement of glucocorticoid-induced 11beta-hydroxysteroid dehydrogenase type 1 expression by proinflammatory cytokines in cultured human amnion fibrob- lasts. Endocrinology 2003, ... enzyme 11β-HSD1, which exhibited cell-specific and cytokine-specific variations in expression and activity. Cytokine induction of stromal cell 11β- HSD1 has previously been repor...

Ngày tải lên: 09/08/2014, 08:22

... expression levels controlled by proinflammatory cytokines and increased responses to TLR ligands. GM-CSF was shown to play an important role in inflammatory sig- naling in a model of LPS-induced ... Alterna- tively, they suggest that separate expression control of TLR5 by inflammatory cytokines may contribute to regulation of innate immunity in monocytes and neu- trop...

Ngày tải lên: 08/08/2014, 16:23

... for- mation in the developing embryo by antagonizing Ang-1- induced autophosphorylation of Tie2 [6]. Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and ... determine the expression of Ang-1, Ang-2, Tie1 and Tie2 in synovial tissue of normal subjects and those with RA and OA. Ang-1, Ang-2, Tie1 and Tie2 mRNA and...

Ngày tải lên: 09/08/2014, 03:24

... chronically inflamed synovial tissue [7,8]. Both the residual synovial-lining cells and infiltrating leuko- cytes are the source of pro-inflammatory chemokines such as CCL2, CCL3, CCL5, CCL20, CXCL9 and ... were analyzed. Expression levels of chemokine receptors were measured by flow cytometry and were compared between the different patient groups and healthy individuals. The an...

Ngày tải lên: 09/08/2014, 06:23

... (TRAF6) was determined by polymerase chain reaction, enzyme-linked immunosorbent assay, Western blotting, and cytofluorometry. RANK signaling was analyzed by the degradation of inhibitor of kappaB-alpha ... adapter protein in neutrophil biology. Conclusion Direct evidence is provided for the differential expression of proteins of the RANK/RANK-L pathway in neutrophils in...

Ngày tải lên: 09/08/2014, 10:20

... activated, probably as a result of inflammation in RA ST. Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (Pyk)2 are two members of a family of nonreceptor protein tyrosine kinases that ... by a variety of extracellular stimuli [1]. FAK and Pyk2 associate with the cytoskeleton and with integrin-signaling complexes by binding to Src kinase and paxillin [2-5]. F...

Ngày tải lên: 09/08/2014, 10:21

... ligands induce production of pro-inflammatory cytokines by bronchoalveolar cells and monocytes To assess the cytokine-inducing functional capability of TLR2, TLR4 and TLR9, we assessed the release of ... and monocytes from healthy donors were analyzed by flow cytometry using phycoerythrin (PE)-coupled mouse anti-TLR2, TLR4 and TLR9 antibodies and their corresponding isotype co...

Ngày tải lên: 12/08/2014, 14:20

... levels Western blot analysis of the metallothionein proteinsFigure 5 Western blot analysis of the metallothionein proteins. Immunoreactive bands of total metallothionein of pooled frac- tions of the Doberman ... (GSH) is induced slightly in mRNA expression in the N-CASH group, and is doubled in the Schematic overview of intra-cellular copper trafficking in hepatocytesF...

Ngày tải lên: 13/08/2014, 13:20

... are readily secreted in mammalian [20] and insect [5] cells, respectively. Cystatin F is an unusual type 2 cystatin in that it is a glycoprotein [5,6], and it is known that many proteins found in intracellular ... cystatins, the kininogens, are larger proteins containing three tandemly repeated type 2-like cystatin domains. Type 2 cystatins identified in higher animals include cyst...

Ngày tải lên: 21/02/2014, 01:21