... development. Androgen insensi-
tivity syndromes stem from aberrations in this pathway.
A. 5-ALPHA-REDUCTASE DEFICIENCY
5-Alpha-reductase deficiency results in normal develop-
ment of the testes and ... receive lifelong testoste-
rone for normal virilization and sexual function.
D. SERTOLI-CELL-ONLY SYNDROME
Also referred to as germ cell aplasia, the hallmarks of Ser-
toli-cell-only syndrome...
... more recently, recombinant interferon-alpha (r-IFN-
α). Various doses and schedules of r-IFN-α have demon-
strated reproducible overall response rates of 10 15% in
advanced renal cancer (Pastore ... with meta-
static melanoma or renal cell cancer using high-dose bolus inter-
leukin-2. JAMA 1994;271:907.
Rosenberg SA et al: Use of tumor-infiltrating lymphocytes and inter-
leukin-2 in the ......
... early
prognosis, and long-term follow-up shows a recurrence
rate of about 10% . Patients with the ectopic ACTH syn-
drome and malignant tumors in general have a poor prog-
nosis; these patients ... is
measured in a 24-hour urine collection (normal range, 10
50 µg/24 h). A urine cortisol value more than twofold ele-
vated is typical of Cushing’s syndrome. False-positive eleva-
tions can o...
... in patients with diabetes insipidus.
Figure 36 10. Obstructed megaureter. Follow-up study
in a 9-month-old boy with unilateral hydronephrosis de-
tected by ultrasonography in utero. Excretory ... nephropathy. NEJM 2003;349:2326–33.
Narkun-Burgess DM, Nolan CR, Norman JE et al: Forty-five year fol-
low-up after uninephrectomy. Kidney Int 1993;43:1 110 5.
North American Pediatric Renal Transpl...