Báo cáo khoa học: "Induction of cell-cell fusion by ectromelia virus is not inhibited by its fusion inhibitory complex" doc

... the presence of viral antigens as appears by immunohisto- chemistry (Fig. 8B). Discussion Virus induced cell-cell fusion (syncytia) is a well-charac- terized phenomenon in many viruses [19]. In poxviruses, syncytia ... that deletion of certain members of this complex result in inhibition of virus entry and of pH- dependent cell-cell fusion. Thus, the current model for...

Ngày tải lên: 12/08/2014, 04:20

... genes induced by all-trans retinoic acid [4]; KLF4 could induce inhibition of proliferation of VSMC, which is mechanistically linked to a KLF4-induced enhance- ment of the expression of the tumour ... for excretion, which is known as reverse cholesterol trans- port and is a protective mechanism against the devel- opment of atherosclerosis. By using the matinspector Profess...

Ngày tải lên: 18/02/2014, 04:20

... knockdown of all Shc isoforms strongly reduced Decma-induced Erk phos- phorylation. Moreover, expression of silent mutants of Shc isoforms showed that only p46 Shc and p52 Shc res- cued the effect of ... described in this report is a consequence of Decma acting as a ligand for E-cadherin. However, several lines of evidence suggest it is the disruption of cell–cell adhesion t...

Ngày tải lên: 19/02/2014, 05:20

... an agonistic effect, but this is weak and not isoform speci- fic [32]. PGI 2 , an AA derivative formed by the succes- sive action of Cox and PGIS, has been suggested as a PPARb specific agonist [2,33,34]. ... lack of activation by PGI 2 was not due to rate-limiting levels of the obligatory PPAR hetero- dimerization partner. These results clearly suggested that PGI 2 is not a...

Ngày tải lên: 07/03/2014, 12:20

... cooling curves is charac- teristic of this transition and is caused by the slow rate of interconversion of two forms of anhydrous choles- terol crystals [15]. The polymorphic transition of anhy- drous ... cationic residues comprised of four or more Lys or Arg residues in sequence. One of the few examples we have found is the membrane fusion protein, p15, of baboon re...

Ngày tải lên: 07/03/2014, 17:20

... dioxins is related to their action as ‘endocrine disrupters’. The endocrine disrupter function includes changes of expression of dioxin target genes, one of which is the gene encoding TCTP [21]. Dioxins ... improved expression by hypoxia is partially controlled by UTRs of the appropriate mRNAs in interaction with RNA-BPs [26,27]. In the case of TCTP mRNA, this view is su...

Ngày tải lên: 16/03/2014, 05:20

... self-inacti- vation of PAI-1 is a crucial regulatory mechanism, by which this protein functions in circulation. Another mechanism of PAI-1 regulation results from the tran- scriptional control of its expression. ... the suppression of NF-jB. Although TNFa could activate NF-jB by a ROS-independent mechanism, the ability of ROS to stimulate NF-jB activity may provide a synergi...

Ngày tải lên: 30/03/2014, 11:20

... McOrist 4 , In-Soo Choi 1 , Joong-Bok Lee 1, * 1 Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea 2 Department of Physiology College of ... correlates with the regression of testes. Fusion proteins composed of canine GnRH and T helper (Th) cell epitope p35 originated from canine distemper virus (CDV) F protein and goat...

Ngày tải lên: 07/08/2014, 18:21

... of cypermethrin on oxidative stress after dermal application 259 Exacerbated responses to oxidative stress by an Na + load in isolated nerve terminals: the role of ATP depletion and rise of ... Induction of mitotic cell division disturbances and mitotic arrest by pyrethroids in V79 cell cultures. Toxicol Lett 1999, 107, 81-87. 15. Hafeman DG, Sunde RA, Hoekstra WG. Effect of...

Ngày tải lên: 07/08/2014, 23:22

... the clinical rele- vance of up-regulation of target genes for the treatment of many disease conditions clearly exists. One of the obsta- cles for this up-regulation is to identify the transcription factors ... for their experimental assistance. We also thank Dr. T. Kocarek and L. Wang for their critical readings of this manuscript. Performance of this work was facilitated by...

Ngày tải lên: 10/08/2014, 22:20