... rubripes;Brare, Danio rerio; Anoga, Anopheles gambiae; Drome,Drosophila melanogaster; Sacce, Saccharomyces cerevisi-ae; Schizo, Schizosaccharomyces pombe; Ciona, Cionaintestinalis; Caeel, Caenorhabditis ... variants of various lengths; each variantencodes distinct protein domain architectures thatshare a canonical bipartite nuclear localization signal and a PHD domain (Zn finger) at the N-terminalregion. ... (Fig. 1), in which the SPP1 representatives are at the basal branch of CGBP and DIO. The GCBP proteins contain a PHD domain, fol-lowed by a DNA-binding domain (the zf-CXXC) and the newly described...