Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx

... Therapies and Vaccines Open Access Original research Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults Renata ... alteration in humoral immune response seen as a shift in isotype from IgG to IgA, suggesting that oral revaccina- tion is capable of provo...

Ngày tải lên: 11/08/2014, 10:23

... detected interferon (IFN)-γ staining but no interleukin (IL)-4 staining. Mul- tiplex cytokine assay was used to analyse the cytokine profile of three T-cell line supernatants. (b) An excess of ... flow cytometry. T-cell lines were derived after sorting for proliferating T cells (CFSE low ). Cytokine expression in CI-responsive T cells was detected by intracellular staining/flow cyto...

Ngày tải lên: 09/08/2014, 08:22

... detailed analysis of reproducibility in subjects most likely to be referred to a laboratory for exercise testing to identify EIB, i.e. subjects with mild symptoms of asthma but without a definite ... study offered an ideal opportunity to determine reproducibility of the response to exercise in a large group in an unbiased manner. The usefulness of these data are not...

Ngày tải lên: 12/08/2014, 11:22

... been shown to inhibit proteolytic activity by binding to the inactive PR subunits and preventing their association into active dimer [16–19]. Peptides corresponding to the C-terminal segment of the ... mutation in the p51 subunit of HIV-1 RT [55]. The introduction of this mutation into RT significantly diminishes the ability of TSAO to bind to and inhibit the enzyme [55]...

Ngày tải lên: 08/03/2014, 09:20

... a serine peptidase characterized by oligopeptidase activity. It is grouped in family S9A in clan SC [1]. Enzymes belonging to clan SC are distinct from trypsin-type and subtilisin-type serine ... lines show reduced remaining activity and expression intensity compared with wild-type cell line U343. Remaining acti- vity ¼ percentage of the activity found in wild-type U343 cells; rem...

Ngày tải lên: 31/03/2014, 08:20

... hours, inflammatory cell responses in the synovial tissue were clearly provoked. Activation by inflammatory stimuli after antibody transfer to the mice was indicated by increases in leukocyte rolling ... extended role as a regulatory molecule of innate immunity. Of course, inter- esting questions remain to be answered in further studies: the effect of ALP on the regulation...

Ngày tải lên: 09/08/2014, 08:22

... regulated by distinct kinase pathways independent of inhibitor of κB kinase (IKK). Here, we examine the role of protein kinase C isoforms and janus activated kinase 2 (JAK2) activation in NF-κB ... expression during such inflammatory responses. A range of inflammatory stimuli, including endotoxin [1,2] and cytokines [3], produce activation and nuclear translo- cation of NFκB fol...

Ngày tải lên: 11/08/2014, 08:21

... TH2 inflammatory cytokines IL-4, IL-5 and IL-13 Generation of pathogenic Th2 cells is the main cause of asthma. We measured a panel of proinflammatory cytokines in lung homogenates by using ... activation in A549 cells Increased synthesis of nitric oxide (NO) during airway inflammation caused by induction of nitric oxide syn- thase-2 in several lung cell types may contrib...

Ngày tải lên: 12/08/2014, 14:20

... population of T cells to redirect their cytokine response to secrete predominantly IL-4, a cytokine known to ameliorate arthritis. The ability to induce a population of regulatory-like T cells to secrete suppressive ... treatment of RA are currently broad based, designed for introducing cytok- ines [3,4,18-22]. The capability of collagen peptides to act locally to indu...

Ngày tải lên: 12/08/2014, 14:22

... two inflammatory cytokines that are well defined as critical inflammatory m ediators in arthritis [18]. TNF-a is pro- posed to be the dominant pro-inflammatory cytokine in the inflammatory manifestations ... largely cytosolic (Figure 6). Discussion In this study, we examined the use of innate immune- modulatory IDR peptides in limiting IL-1b-induced inflammatory responses in s...

Ngày tải lên: 12/08/2014, 17:22