nature of the immune response to adenoviral vectors
Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... concurrent analysis of the phenotype and proliferative response of antigen-specific T cells was used to study the immune response to a specific antigen [17] We employed a similar method to demonstrate ... = 0.359) None of the SSc-related disease manifestations was predictive of an immune response to CI in vitro, except for a trend toward more lung fibrosis in the CI responders Of the CI responders, ... Multiplex cytokine assay was used to analyse the cytokine profile of three T-cell line supernatants (b) An excess of Th1 over Th2 cytokines was detected PE, phycoerythrin; TNF, tumour necrosis factor...
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Báo cáo y học: "Using an agent-based model to analyze the dynamic communication network of the immune response" docx
... ticks The plots show the frequency distribution of the contacts as log10 of the number of nodes vs the log10 of the number of links per node for the first 400 ticks of the simulation for the given ... to set one of the challenges to the immune system at the top of the list “Set_ViralInfection:” and “Set_Bacti:” are the verified choices A ‘1’ must be typed in to replace the ‘0’ for one of the ... distributions of contacts for each immune agent type at 1000 ticks The plots show the frequency distribution of the contacts as log10 of the number of nodes vs the log10 of the number of links per...
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Báo cáo y học: "Mactinin: a modulator of the monocyte response to inflammation" pps
... decided to pursue this further Owing to the autoimmune nature of rheumatoid arthritis, we examined whether mactinin was present in immune complexes That is, antibody-bound mactinin might not bind to ... material at the top of the gel (data not shown) Hence, the R313 Arthritis Research & Therapy Vol No Luikart et al Figure Dissociation of immune complexes in rheumatoid arthritis fluid An aliquot of rheumatoid ... role in the pathogenesis of chronic arthritis [8] The release of proinflammatory cytokines, chemokines, growth factors, and enzymes by the synovial lining macrophages is important for the onset,...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx
... consented to the immune response kinetic study (Table 1) and just two of them agreed to have an oral booster vaccination 42 days after primary immunisation Of these subjects, gave a history of contact ... capable of mounting humoral and cellular immune responses to the antigens tested The data presented here will form the basis for further studies with larger numbers of subjects, with the aim of studying ... immunoglobulins isotypes, other cytokines of importance in mucosal immune responses as well as responses to purified secreted proteins Competing interests The kinetics of lymphoproliferative response described...
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báo cáo khoa học: " Public health the leading force of the Indonesian response to the HIV/AIDS crisis among people who inject drugs" doc
... (two of the main provinces of Indonesia) is to lead the response and use the infrastructure of the health system to scale the response to the level of the epidemic The expansion was based on ... 2007, 4:9 motion of safe sex than to the promotion of safer use of drugs Advocacy of the police is the most difficult part of the job Indonesia has a history of militarization of the street police ... experience conducted in the City of Sao Paulo, Brazil, from 2001 to the present [10] Today the aim of the current projects is to achieve treatment of 30% of the injecting drug users in the country but...
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Báo cáo y học: " Reproducibility of the airway response to an exercise protocol standardized for intensity, duration, and inspired air conditions, in subjects with symptoms suggestive of asthma" pdf
... is Chief of the Division of Allergy/Immunology and Director of the Asthma Clinical Research Center at the University of California Competing interests SDA is the inventor of the mannitol test ... reproducibility of the exercise response in relation to the different NAEPPII scores is given in Table There was no relationship between the NAEPII score and the severity of the response to exercise ... reproducibility of the airway response to exercise in the type of individual most likely to be referred for exercise testing for EIB Exercise testing to identify EIB in the laboratory is affected by the...
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Characterization of the cellular response to hypoxia
... thus leading to mTORC1 activation In the second pathway, presence of amino acids leads to the Rag-GTPases-Ragulator dependent translocation of mTORC1 to the lysosomal surface, where mTORC1 is activated ... comparable effect on mTORC1 activities in all cell lines Taken together, these results strongly suggest REDD1 does not play a role as the key mediator of the rapid response of mTORC1 to hypoxia and ... exposed to hypoxic conditions were not significantly lower compared to cells in normoxia Therefore, the focus of the last part of the project was to characterize the hypoxia-independent regulation of...
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study on the immune response of orange spotted grouper (epinephelus coioides hamilton, 1822) cultured in khanh hoa province to bacteria vibrio parahaemolyticus
... causing the ulcerative disease in grouper Study on the effect of oral administration β-glucan on the native immune response of orange-spotted grouper Study on the specific immune response of orange-spotted ... Influence factors for fish immune responses Factors affecting fish immune responses include factors related to fish ontogenesis Among environmental factors, temperature has been shown to greatly ... Observation of phagocytic activity was based on the ability to ingest the fluorescent beads of HKL according to Yeh et al (2008); The respiratory burst activity of HKL were measured according to Cheng...
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Báo cáo y học: "Celastrus aculeatus Merr. suppresses the induction and progression of autoimmune arthritis by modulating immune response to heat-shock protein 65" pptx
... secretion of anti-inflammatory cytokines over proinflammatory cytokines in response to Bhsp65 To test and compare the T cell proliferative and cytokine response to the disease-related antigen Bhsp65 of ... turn generate some of the critical mediators of the inflammatory response [14,15,35] In fact, some of the active components of Celastrus have been shown to serve as inhibitors of the NF-κB pathway ... deviation) of the cytokine response to an anti-inflammatory type [26] This relative deviation of the cytokine response, caused either by decreased Th1-type cytokines and/or by enhanced Th2-type cytokines...
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Báo cáo y học: " Characterization of the innate immune response to chronic aspiration in a novel rodent model" ppsx
... aspiration of either gastric fluid or normal saline are shown The ratio of macrophages in the left to the macrophage in the right lung is shown as a function of time In the inset, the ratio of macrophages ... phenotypic response It is also quite possible that, in the setting of a pulmonary allograft, the development of these inflammatory mediators could recruit and/or exacerbate immune responses that ... predispose recipients to acute and/or chronic rejection The activation of TH1 immune pathways and the generation of a cytotoxic response has been associated with rejection in a number of lung allograft...
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INVESTIGATING THE HOST IMMUNE RESPONSE TO MYCOBACTERIUM TUBERCULOSIS THE ROLES OF ANNEXIN a1 PROTEIN AND CLEC9A+ DENDRITIC CELLS
... The heterogeneous consequences of M tuberculosis infection The implications of the heterogeneity of the host immune response to M tuberculosis infection are becoming increasingly recognised The ... crucial to the delivery of antigen from the site of infection to the draining LN, where the initial activation of T cells occurs (Wolf et al., 2008) In addition, DCs are unique in their ability to ... dissemination is initiated by the migration of infected DCs to the draining LN (Humphreys et al., 2006) Taken together, these studies suggest that the migratory properties of infected DCs is 18 Chapter...
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The Future of Justification: A Response to N. T. Wright pptx
... least to draw together the identity of the whole of God’s people so that what is true of him is true of them and vice versa Here we arrive at one of the great truths of the gospel, which is that the ... up into the one body “joined and held together” as we “attain to the unity of the faith and of the knowledge of the Son of God” (Eph 4:13, 16) “Grace and peace” 7He addresses the danger of boasting ... indeed into the mould of the doctrine that the mind embraceth—when the evidence and necessity of the truth abides in us—when not the sense of the words only is in our heads, but the sense of the thing...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... In recent years the concept of ‘inhibitory receptors’ that function to moderate immune responses has grown in prominence [27,28] Targeting these types of receptors on inflammatory cells in diseases ... against NaCl/Pi To construct the GST fusion of the siglec-10 cytoplasmic domain (GST– siglec-10cyto-wt) the cytoplasmic domain (KRRTQTE…VFQ) of siglec-10 was amplified from a phytohaemagglutinin-activated ... focus more effort to determine if siglec-10 binding can be further enhanced with activation of the cells prior to testing The amino-acid sequences of the cytoplasmic tails of several siglec proteins...
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báo cáo hóa học:" Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist" potx
... effect of overnight shipping on inhibition of internalization of AF488-MCP-1 by the receptor antagonist a direct comparison of the effect of overnight storage on the IC50 of the CCR2 inhibitor was ... important to demonstrate the ability of the CCR2 antagonist to inhibit the saturating concentration of the AF488-MCP-1 used in the assay To accomplish this CCR2 antagonist was titrated into the assay ... to results obtained by processing the whole blood after only one hour incubation with the CCR2 antagonist The sensitivity of the assay, or the ability of the assay to demonstrate inhibition of...
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báo cáo hóa học: " Wallerian degeneration: the innate-immune response to traumatic nerve injury" potx
... is given to the orchestration of these events with respect to their timing and magnitude, and to the identity of the cells that produce them Timing differs between species (see below) Therefore, ... Faculty of Medicine, Jerusalem, Israel innate -immune response of the PNS to traumatic nerve injury (e.g recruitment of macrophages, phagocytosis of degenerated myelin, and production of cytokines ... cytokines Therefore, the development of some neurotrophic properties is tightly associated with the development of the innateimmune properties of normal Wallerian degeneration The failure to...
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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc
... determine if the increased cell death observed in the injured brains of MT-I/II-/mice is due to the absence of the neuroprotective effects of MT-I/II in the CNS or the absence of the modulatory effects ... neurotoxic and can impede the resolution of brain injury [19-21] It is feasible that the number of immune cells entering the CNS can influence the progression of brain injury but the phenotype of ... expose the cranium and the steel rod was then applied directly to the skull for seconds The stereotaxic coordinates for the injury site were mm anterior of lambda and mm right of the midline The...
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báo cáo hóa học:" A decade of modelling research yields considerable evidence for the importance of concurrency: a response to Sawers and Stillwaggon" potx
... Page of Sawers and Stillwaggon repeat when they discuss these models in terms of the assumptions they make “[i]n order to generate rapid spread of HIV” Few of these models have the goal of accurately ... Page of transmissibility of HIV during each stage of infection These confirm that concurrent relationships have a strong ability to amplify the spread of HIV relative to the same number of sequential ... relationships The first of these [11], published by a research group without access to the dynamic statnet tools then still in development, chose the time-intensive task of reproducing the original...
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Báo cáo khoa học: "The behavior of oaks in response to natural and induced exposure to the surfactant ABS" potx
... as- the leaf to different waxes of all spe- degrees Damage included: disaggregation and fusion of the epicuticular and epistomatic wax, deactivation of the stomata (through occlusion or damage to ... structural degradation of the leaf waxes similar to that of the year before, but the relative tolerance among the species was unchanged In the culture ABS, pollen damaged trees than in the healthy-looking ... attributed to wind-borne surfactants from the sea (Gellini et al, 1983, 1985) The present study seeks to assess the effect of natural and artificial exposure to ABS on the leaf waxes of oak species...
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Báo cáo khoa học: "Preliminary study of the monoterpene response of three pines to Ophiostoma clavigerum (Ascomycetes : Ophiostomatales) and two chemical elicitors" pot
... is the main line of tree defense against the attack of the bark beetle and its associated fungus However, the nature and the origin of the chemical elicitor responsible for the stimulation of the ... higher accumulation of monoterpenes than the chemical treatments In P ponderosa however, the quantitative response to chitosan was often close to the response to the fungus The terpene accumulations ... was not to define the qualitative re- sponse of these species but rather to compare the terpene composition of responding tissues with that of unwounded tissues of the same tree Although there...
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Báo cáo y học: "Synergistic role of c-Myc and ERK1/2 in the mitogenic response to TGF-1 in cultured rat nucleus pulposus cells" ppsx
... was therefore to reveal the role of c-Myc in mitogenic response to TGF1 in nucleus pulposus cells The study was designed to (1) analyze the effect of TGF1 on cell proliferation and the cell cycle ... individuals, these inhibitors both seem to block the mitogenic effect of TGF1 completely The statistical significance by the repeated measures ANOVA of the cell cycle experiment was p = 3.213E-3 The ... Additionally, to examine the possibility of involvement of the MAPK pathway in regulation of c-Myc stability, we devised serial experiments using the pathway specific inhibitors 10058-F4, an inhibitor of...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25