Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf

... erences in clinical outcomes, including mortality, rates of endotracheal intubation, length of stay, or myocardial infarction.  ere were no diff erences between CPAP and NIPPV in any of the ... including decreasing respiratory acidosis, respiratory rate, work of breathing, heart rate, and sensation of dyspnea [5,6]. It may also reduce rates of endotracheal intubatio...

Ngày tải lên: 13/08/2014, 20:21

... K, Danahay H: Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am J Physiol Lung Cell ... efficacy of candidate compounds, ideally one would examine the same endpoints in the models as in the clinic. Typically, early proof -of- concept studies for COPD anti-infl...

Ngày tải lên: 12/08/2014, 11:22

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparently playing a less important role in side-chain binding. Taken together, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N (Arg160 and Arg162) and the carboxylate of the a-amino- adipoyl side-chain (Arg266). The resul...

Ngày tải lên: 18/03/2014, 01:20

... activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892. 7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam- matory therapy. ... their role in bone metabolism and repair remains unclear. Review of the evidence To determine the role of COX-2 in bone repair, investiga- tors have studied fracture healing in...

Ngày tải lên: 09/08/2014, 01:21

... spondyloepiphyseal dys- plasia tarda, brachydactyly, and precocious osteoarthritis associated with an arginine 75 →→ cysteine mutation in the pro- collagen type II gene in a kindred of Chiloe Islanders. ... deafness Hypochondrogenesis Kniest dysplasia Osteoarthritis with mild dysplasia Spondyloepiphyseal dysplasia, congenital type Spondyloepiphyseal dysplasia, Namaqualand type Spondyl...

Ngày tải lên: 09/08/2014, 06:22

... article The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration Christine Lyn Le Maitre, Anthony J Freemont and Judith Alison Hoyland Division of Laboratory and Regenerative ... Taylor F: Induction of matrix metal- loproteinase-2 and -3 activity in ovine nucleus pulposus cells grown in three-dimensional agarose gel culture by interleukin-...

Ngày tải lên: 09/08/2014, 06:22

... cell death induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary for anaerobic energy generation and proteoglycan synthesis by articular chondrocytes, ... conditions. Using RNA-interference, Yudoh and colleagues [1] further analyzed the role of HIF-1 in chondrocytic energy generation, matrix synthesis and cell survival. During hypox...

Ngày tải lên: 09/08/2014, 07:20

... proinflammatory effects in the kidney and other tissues [13,14], such as leuko- cyte infiltration and increased expression of inflammatory cytokines. In addition, aldosterone can generate cytosolic ... relationship between acute inflammatory and chronic fibrotic nephropathy is unclear [3-5]. Thus, therapeutics focusing solely on suppression of inflammation may be inadequate...

Ngày tải lên: 09/08/2014, 10:22

... the importance of decreasing pain and increasing function; and expectations of surgery in relation to expected time until full recovery (open answer, in months), expected pain after recov- ery from surgery ... outcome (yes, definitely; yes, probably; no, probably not; no, definitely not). In summary, expectations were measured at baseline, and cur- rent pain and function wer...

Ngày tải lên: 09/08/2014, 14:22

... fraction of introns that contain TEs in invertebrates D. melanogaster and C. elegans is 1.7% and 5.6%, respectively. These results indicate that only a very small portion of introns in invertebrates ... of exonizations within human and mouse (around 1,800 new exons in human and around 500 new exons in mouse [16]) is mainly attributed to the existence of very large intr...

Ngày tải lên: 09/08/2014, 20:22