Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf

Báo cáo y học: "The role of noninvasive ventilation in acute cardiogenic pulmonary edema" pps

... erences in clinical outcomes, including mortality, rates of endotracheal intubation, length of stay, or myocardial infarction.  ere were no diﬀ erences between CPAP and NIPPV in any of the ... including decreasing respiratory acidosis, respiratory rate, work of breathing, heart rate, and sensation of dyspnea [5,6]. It may also reduce rates of endotracheal intubation [5,7,8]. A variety ... Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA2Assistant Professor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine,...

Báo cáo y học: " Pharmacological characterisation of antiinflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation" ppt

... K, Danahay H:Characterization of cigarette smoke-induced inflammatory and mucushypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. Am J Physiol Lung Cell ... efficacy of candidate compounds,ideally one would examine the same endpoints in themodels as in the clinic. Typically, early proof -of- conceptstudies for COPD anti-inflammatory strategies in manassess ... statins actas anti-inflammatory agents, although their ability toblock adhesion molecules and preventing the prenyla-tion of proteins involved in inflammatory signaling (e.g.GTP-binding proteins)...

Báo cáo Y học: The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase potx

... carboxyl group of the a-aminoadipoyl- side-chain of penicillin N (1), with arginines 74 and 75 apparentlyplaying a less important role in side-chain binding. Takentogether, the results of this and ... residues in binding the carboxylate linked to the nucleus of penicillin N(Arg160 and Arg162) and the carboxylate of the a-amino-adipoyl side-chain (Arg266). The results for mutation of Arg74 and ... ternary com-plex to oxygen binding, thereby initiating catalysis and ensuring coupling of 2-oxoglutarate conversion to primesubstrate oxidation. In the case of DAOCS it has been previously shown...

Báo cáo y học: "The role of cyclooxygenase-2 in bone repair" doc

... activity of a glucocorticoid-regulated inflammatorycyclooxygenase. Proc Natl Acad Sci USA 1992, 89:4888-4892.7. Raskin JB: Gastrointestinal effects of nonsteroidal anti-inflam-matory therapy. ... their role in bone metabolism and repairremains unclear.Review of the evidenceTo determine the role of COX-2 in bone repair, investiga-tors have studied fracture healing in animal models of COX-2 ... critical role of COX-2 in mesenchymal cell differentiation during skeletal repair.Using COX-1-null and COX-2-null mice, they demon-strated the essential role of COX-2 in both endochondral and intramembranous...

Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx

... spondyloepiphyseal dys-plasia tarda, brachydactyly, and precocious osteoarthritisassociated with an arginine 75→→cysteine mutation in the pro-collagen type II gene in a kindred of Chiloe Islanders. ... deafnessHypochondrogenesisKniest dysplasiaOsteoarthritis with mild dysplasiaSpondyloepiphyseal dysplasia, congenital typeSpondyloepiphyseal dysplasia, Namaqualand typeSpondyloepiphyseal dysplasia, Strudwick typeSpondyloepiphyseal ... matrixCollagensTypes IIa and IIbType IIIType VIType IXType XType XIType XIIType XIVProteoglycansAggrecanVersicanLink proteinBiglycan (DS-PGI)Decorin (DS-PGII)Epiphycan (DS-PGIII)FibromodulinLumicanPerlecanProteoglycan...

Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf

... articleThe role of interleukin-1 in the pathogenesis of human Intervertebral disc degenerationChristine Lyn Le Maitre, Anthony J Freemont and Judith Alison HoylandDivision of Laboratory and Regenerative ... Taylor F: Induction of matrix metal-loproteinase-2 and -3 activity in ovine nucleus pulposus cellsgrown in three-dimensional agarose gel culture by interleukin-1beta: a potential pathway of ... Aldape RA, Raybuck SA, et al.: Struc-ture and mechanism of interleukin-1 beta converting enzyme.Nature 1994, 370:270-275.42. Dinarello CA: From Interleukin-1. In The cytokine handbook 3rdedition....

Báo cáo y học: "α The role of HIF-1α in maintaining cartilage homeostasis and during the pathogenesis of osteoarthritis" pot

... celldeath induced by pro-inflammatory cytokines. Finally, Yudoh and colleagues showed that HIF-1α is necessary foranaerobic energy generation and proteoglycan synthesis byarticular chondrocytes, ... conditions.Using RNA-interference, Yudoh and colleagues [1] furtheranalyzed the role of HIF-1 in chondrocytic energy generation,matrix synthesis and cell survival. During hypoxic and normoxic ... expression of VEGF-A via HIF-1. In conclusion, the α-subunit of HIF-1 is stabilized and HIF-1activity is significantly increased in chondrocytes by hypoxic,inflammatory and mechanical stress. Thus, in...

Báo cáo y học: "The role of aldosterone blockade in murine lupus nephritis" pdf

... proinflammatoryeffects in the kidney and other tissues [13,14], such as leuko-cyte infiltration and increased expression of inflammatorycytokines. In addition, aldosterone can generate cytosolic ... relationship between acute inflammatory and chronic fibrotic nephropathy is unclear [3-5]. Thus,therapeutics focusing solely on suppression of inflammationmay be inadequate in preventing terminal fibrotic ... Additionally, spironolactonetreatment resulted in decreased expression in the kidney of several inflammatory and proapoptotic genes, including thoseencoding interferon-γ, B lymphocyte stimulator (BlyS),...

Báo cáo y học: "The role of patient expectations in predicting outcome after total knee arthroplasty" ppsx

... theimportance of decreasing pain and increasing function; and expectations of surgery in relation to expected time until fullrecovery (open answer, in months), expected pain after recov-ery from surgery ... outcome (yes, definitely; yes,probably; no, probably not; no, definitely not). In summary, expectations were measured at baseline, and cur-rent pain and function were measured prospectively (eachpreoperatively ... prospectively (eachpreoperatively and at 2 years), also yielding a measure of thechange in pain and function. In each expectations domain(time to recovery, pain, and function), the difference...

Báo cáo y học: "The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates" doc

... fraction of introns that contain TEs in invertebrates D. melanogaster and C. elegans is 1.7% and 5.6%, respectively. Theseresults indicate that only a very small portion of introns in invertebrates ... of exonizations within human and mouse (around 1,800 new exons in human and around500 new exons in mouse [16]) is mainly attributed to theexistence of very large introns and the dominance of ... implying that TE insertions haveplayed a role in the evolution of intron size.Previous analysis of human and mouse transcriptomesrevealed that there is a biased insertion and fixation of some...

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