... active form of vitamin D, 1,25-dihydroxyvitamin D 3(VD3), belongs to the secos-teroid hormone family, which controls calcium andKeywords1,25-dihydroxyvitamin D 3; 5-aza-2¢-deoxycytidine; gastric ... PI, propidium iodide; PTEN, phosphatase and tensinhomolog deleted on chromosome 10; siRNA, small interfering RNA; TSA, trichostatin A; VD3, 1,25-dihydroxyvitamin D 3;VDR, vitamin D receptor.FEBS ... 989 Vitamin D promoted the apoptosis induced by5-AzaWe then investigated the effect of PTEN on the apop-tosis induced by DNA methylation and vitamin D ingastric cancer cells. We treated HGC-27...