... howosmosensing and osmosignaling integrate into the overall context of growthfactor signaling and the execution of apoptotic programs.AbbreviationsEGF, epidermal growth factor; MAPK, mitogen-activated ... hydration as the primary factor in carcinogenesis: a unifying concept. Med Hypotheses66, 518–526.25 Maeno E, IshizakiY, Kanaseki T, Hazama A &OkadaY (2000) Normotonic cell shrinkage because ... of autophagic proteolysis [14]. Thus, integrin-dependentcell volume sensing and signaling integrates into the overall context of insulin signaling. Similarly, sensing of glutamine-induced hepatocyte...