báo cáo khoa học: "Role of Wnt canonical pathway in hematological malignancies" pps

... under- standing the cellular and molecular mechanisms of Wnt signaling. A lot of studies indicate that Wnt canonical pathway involves in the pathogenesis of a range of dis- ease including many kinds of ... angiogenesis. Role of Wnt canonical signaling in carcinomas Wnt canonical signaling is involved i n pathogenesis of several carcinomas and the mechanisms...

Ngày tải lên: 10/08/2014, 22:21

... fosfomycin binding due to charge–charge repulsions. Most interestingly, the uncharged valine side chain completely abolishes fosfomycin binding in the absence of UDPNAG. Clearly, UDPNAG binding creates additional ... not interact with R124 in the ternary complex [20]. Hence, the mechanism of binding of fosfomycin by reinforcement of an initial binding site (mainly K22 and R397) th...

Ngày tải lên: 19/02/2014, 13:20

... periods of times (0–60 min) at 37 °C. The concentration of the biotinylated Ig remaining on the cell surface was then quantified by measuring the binding of [ 125 I]Streptavidin. In the absence of ... They were then incubated with 0.25 mL of incubation medium containing 2 lgÆmL )1 of biotinylated R5T-34 monoclonal Ig [30] at 4 °C for 30 min. In some cases, monensin 40 l M was a...

Ngày tải lên: 21/02/2014, 00:20

... in DptF is GLDSV, indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence. To determine whether DptF is ... remains to be clarified whether all of the fatty acids activated by DptE can be incorpo- rated into the final product or whether there is an interfering specificity of the C III domain of...

Ngày tải lên: 07/03/2014, 04:20

... proteins was independent of the nature of the C-terminal domain, in contrast to the situation with Nc proteins. Indeed, the C2 domain induced sensitivity of the Nc active site to E600 inhibition in ... tributyrin in the presence of increasing concentrations of bile salts (0–6 mm), in the absence or in the presence of colipase. As seen in Fig. 4, increasing the concentr...

Ngày tải lên: 16/03/2014, 06:20

... optimization of the positions of the hydrogen atoms using energy minimi- zation; (c) optimization of the conformation of the side chain using energy minimization; and (d) optimization of the posi- tions of ... mechanics of noncovalent bonds in polyamino acids. VIII. Cova- lent loops in proteins. Biopolymers 3, 379–399. 52 Goldenberg DP (1985) Dissecting the roles of indivi...

Ngày tải lên: 16/03/2014, 06:20

... sequence of OPN and the N-terminal sequence of dentin matrix acidic phos- phoprotein 1 (DMP1) [27,28] and long sequences of Glu residues in, for example, integrin-binding sialo- phosphoprotein II ... a S1 -casein; CSN1S2, a S2 -casein; CSN2, b-casein; IBSP-II, integrin-binding sialophosphoprotein II; MEPE, matrix extracellular bone phosphoglycoprotein. Potential sites of phosphorylat...

Ngày tải lên: 29/03/2014, 23:20

... (Micromax cooled-CCD, Princeton Instrument, USA). Three sections per animal were examined and the number of MMC was counted in at least 10 randomly selected fields using an image analyzing software. Loss of intracellular ... [12]. Despite these findings, it is still controversial whether MMC plays a key role in IBS. Several investigators have noted an increased number of MMC in te...

Ngày tải lên: 07/08/2014, 18:20

... despite dexamethasone-related increases in body weight, blood pressure, HDL cholesterol and insulin. Changes in calculated indices of insulin sensitivity (HOMA-S, insulin sensitivity index) were strongly related ... CA). Insulin sensitivity was assessed using the homeostatic model (HOMA-S), which is directly related to fasting insulin and glucose levels [13]. A weighted combination of...

Ngày tải lên: 11/08/2014, 08:20

Ngày tải lên: 07/08/2014, 20:23