báo cáo khoa học: "Induction of endogenous γ-globin gene exp

báo cáo khoa học: "Induction of endogenous γ-globin gene expression with decoy oligonucleotide targeting Oct-1 transcription factor consensus sequence" pps

... effect of Oct-1 decoy oligonucleotide treatment on binding of Oct-1 transcription factor to the endogenous γ-globin gene promoter region DNA in K562 cellsFigure 4 The effect of Oct-1 decoy oligonucleotide ... the decoy oligonucleotide designed for the Oct-1 transcription factor consensus sequence could induce expression of the endogenous γ -glo...

Ngày tải lên : 10/08/2014, 22:20

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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc

... treatment of the cells with curcumin, a speciﬁc inhibitor of AP-1, signiﬁcantly diminished S1P-induced endogenous Cyr61/CCN1 gene expression (data not shown). Transcriptional activation of AP-1-regulated ... treated with S1P as compared to nontreated cells consistent with the inducible immediate early gene pattern of the c-fos gene, while endogenous levels of ATF-2...

Ngày tải lên : 08/03/2014, 08:20

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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot

... for suppressing gene expression, they have a number of limitations; a useful review can be found elsewhere [18]. The DNAzyme technique offers a new way of suppressing gene expression. In comparison with ... containing DMEM with 10% fetal bovine serum without antibiotics and then treated with Lipofecta- mine 2000 (Invitrogen) with or without active DNAzyme or scrambled mutant...

Ngày tải lên : 16/03/2014, 22:20

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Báo cáo khoa học: Analysis of dopamine transporter gene expression pattern ) generation of DAT-iCre transgenic mice doc

... representation of the BAC- DATiCre construct and its structure. The position of the DAT gene within the RP23–408F13 BAC is indicated, together with those of the putative genes contained within this ... of essential DNA elements. The expression of a transgene under the control of an endogenous regulatory ele- ment, using knock-in approaches, can prevent these problems but d...

Ngày tải lên : 30/03/2014, 08:20

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Báo cáo khoa học: "Correlation of HER-2 over-expression with clinico-pathological parameters in Tunisian breast carcinoma" ppsx

... negative expression of ER, PR and HER-2 was found in 34 cases (21.9%). Conversely, Simultaneous expression of ER, PR and over expression of HER-2 was found in only 5 cases (3.2%). The percentage of ... nature of the tumors' expression of ER and the age of the patients. These results are in agreement with most reports in the literature which show an association bet...

Ngày tải lên : 09/08/2014, 07:21

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báo cáo khoa học: "Loss-of-function mutations affecting a specific Glycine max R2R3 MYB transcription factor result in brown hilum and brown seed coats" docx

... seed-c oat specific expression of the functional version of this gene was strongly correlated with the level of expression of a UF3GT gene (Glyma08g07130), which encodes a gene product that carries ... confirmed our hypothesis that loss of function mutations within Glyma09g36690, an R2R3 MYB gene, are correlated with reduced expression of a UF3GT gene and ANS ge...

Ngày tải lên : 11/08/2014, 11:21

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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx

... enhance- ment of the expression of the tumour suppressor gene p53 [5]. Because of the important roles of KLF4 on the above three cell types, we postulated the novel effect of KLF4 in atherogenesis. Scavenger ... activation of endothelial cells and macrophages, as well as the differentiation and proliferation of VSMCs. Overexpression of KLF4 induced expression of multip...

Ngày tải lên : 18/02/2014, 04:20

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Tài liệu Báo cáo khoa học: Induction of uPA gene expression by the blockage of E-cadherin via Src- and Shc-dependent Erk signaling docx

... phos- phorylation. Moreover, expression of silent mutants of Shc isoforms showed that only p46 Shc and p52 Shc res- cued the effect of the siRNA. Overexpression of p66 Shc not only failed to ... increased expression of uPA is directly related to higher tumor growth and metastasis [1]. Several analyses have already made it clear that the expression of E-cadherin and the expr...

Ngày tải lên : 19/02/2014, 05:20

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Báo cáo khoa học: Induction of PPARb and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARb potx

... was mainly due to a strong transcriptional activation of the Cox-2 gene (and to a lesser extent of PGIS and mPGES-1). Under the same experimental conditions expression of the PPARb gene was also augmented ... already seen with Cox-2 above. Effect of Raf activation on the transcriptional activity of PPARb The simultaneous upregulation of PGI 2 synthesis and PPARb expressio...

Ngày tải lên : 07/03/2014, 12:20

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Báo cáo khoa học: Induction of raft-like domains by a myristoylated NAP-22 peptide and its Tyr mutant potx

... Difference of spectra with PtdIns(4,5)P2 minus the spectra of the same mixture without PtdIns(4,5)P2. Pairs of spectra are either from samples with cholesterol (+ cholesterol) or without cholesterol ... presence of cholesterol allows a closer proximity of the Tyr side chain of the peptide with the terminal methyl group of the acyl chain of the lipid as shown by the obser...

Ngày tải lên : 07/03/2014, 17:20

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