báo cáo khoa học: "Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression" ppsx

... 29:172 http://www.jeccr.com/content/29/1/172 Page 6 of 8 RESEARCH Open Access Transcription factor c-Myb promotes the invasion of hepatocellular carcinoma cells via increasing osteopontin expression Rong-Xin Chen 1,2 , ... Migration and invasion of HCCLM6 cells in response to transfection of c-Myb siRNA. The c-Myb siRNA could significantly inhibit the...

Ngày tải lên: 10/08/2014, 10:20

... with the intracellular localization of the chaperone correlating with the reconstruction of the intermediate filament network of the cells after heat stress [19]. Initial studies [11] found that the ... [31], the resonance decay (i.e. loss of intensity) of reduced a-lactalbumin in the absence of aB-crystallin arises from aggregation of the molten globule state...

Ngày tải lên: 16/03/2014, 18:20

... and the lung is the most common site of extracranial metastases. On the other hand, the second route is the osseous route via Batson's venous plexus to the skull. In this group, bone is the ... in the advanced stage of HCC [6,7]. One of them is the hematog- enous route via the lung to the brain parenchyma without skull involvement. In this group, the cha...

Ngày tải lên: 09/08/2014, 07:21

... SMMC-7721 cells. The cell proliferation rate of untreated cells was defined as 100% and that of treated cells was expressed as a percentage of the untreated cells. The data represented the mean ... Rodés J, EASL Panel of Experts on HCC: Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for t...

Ngày tải lên: 10/08/2014, 22:21

... in which overexpression of one transcription factor resulted in inhibition of another, was often found in the regulation of eukary- otic gene expression. The repression of AP-2 on Sp1- dependent ... determined the functional role of AP-2a in the regulation of KCTD10. Mutation of the AP-2-binding site increased KCTD10 promoter activity by 88.1%, whereas overex- pressi...

Ngày tải lên: 30/03/2014, 02:20

... target of PF-4 inhibition. Activation of the MAP kinases, ERK1/2, is important for the proliferation of HUVEC [31]. We therefore focused on the effect of PF-4 on the kinases involved in the signalling pathways ... partial inhibition of the binding of VEGF 165 to its receptor [26]. How ever, the levels of tyrosine phosphorylation of the K DR and PLCc were not af...

Ngày tải lên: 19/02/2014, 16:20

... accele rated in the absence of TF probably by the disclosure of a more direct cotranslational targeting pathway to the Sec translocon [3]. Perhaps, the proofreading activity of the Sec t ranslocase ... markers ( at the left side of the pane ls in kDa) are indicated. Ó FEBS 2004 Role of trigger factor in Tat-mediated export (Eur. J. Biochem. 271) 4781 The p resence...

Ngày tải lên: 07/03/2014, 16:20

... all invasive carcinomas and in the subgroup of IDC . This may be due to the early stage of the disease. The major limitation of this study is the small size of the study group. Further studies ... overexpression of cyclin E shor tens the length of G1, acceler ating progression of the cell cycle into the S phase [4]. The activation of cyclin E is mediated th...

Ngày tải lên: 09/08/2014, 01:24

... recent progress in the understanding of how osmosensing and osmosignaling integrate into the overall context of growth factor signaling and the execution of apoptotic programs. Abbreviations EGF, ... H4IIE rat hepa- toma cells to pro-apoptotic signaling by the protea- some inhibitor MG-132 [40]. These and other studies on hyperosmotically shrun- ken cells support the vie...

Ngày tải lên: 18/02/2014, 16:20

... [11,12]. The study of these events is taxing, as the biosynthesis of glycoproteins is not tem- plate driven. This results in the formation of so-called ‘glycoforms’ [11,12], proteins with the same ... 1957 catalyze enhanced hydrolytic degradation of the target protein. More recently, the glycoMTS method has allowed the synthesis of the first examples of a homogeneou...

Ngày tải lên: 18/02/2014, 17:20