... these molecules in normal homeostasis. Review Chemokine blockade: a new era in the treatment of rheumatoid arthritis? Jasper J Haringman and Paul P Tak Division of Clinical Immunology and Rheumatology, Academic ... migration selectively [20]. In that study a highly specific neutralizing antibody against IL-8 was administered in several types of acute inflammato...
Ngày tải lên: 09/08/2014, 01:23
... [ 42] but also as co- stimulators of cells of the adaptive immune system. TLR -2 engagement therefore influences the differentiation of T cells not only by the activation of DCs (indirect pathway Figure ... Toll-like receptor (TLR) -2 on pre-activated T cells in pathogen-induced chronic inflammatory joint diseasesExplanation for the involvement of...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... at 1 year and 2 years of 96% and 89% compared with Viewpoint Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension Frances C Hall University of ... processes underlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps
... article MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis Jinah Jang 1 , Dae-Seog Lim 2 , Young-Eun Choi 1 , Yong Jeong 2 , ... many kinds of different cytokines and growth factors in the RA joint microenvironments. To identify factors having an effect on the growth of RA FLSs,...
Ngày tải lên: 09/08/2014, 08:23
Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf
... measuring sulphated glycosaminoglycans (S-GAGs) are available, these assays do not distinguish between synthesis and degradation of the pro- teoglycans [19]. Furthermore, they do not distinguish ... level of IGF-induced collagen II synthesis after 11 days of cytokine treatment and no IGF-induced colla- gen II synthesis after 17 days of cytokine treatment (Figure 2b). Interesti...
Ngày tải lên: 09/08/2014, 10:23
Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps
... (MPR) for any urate-lowering drug (ULD) useThe distribution of the medication possession ratio (MPR) for any urate- lowering drug (ULD) use. The distribution of the study population in terms of ... dis- pensings of NSAIDs, colchicine and glucocorticoids in the 30 days prior to and including the date of the first ULD dispens- ing. Analyses The characteristics of...
Ngày tải lên: 09/08/2014, 14:20
Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx
... quality control program run by the Korean Society of Laboratory Medicine [3]. In 1999 and 2007, reports of antinuclear antibody test using the IT-1 cell line on 208 and 588 systemic lupus erythematosus (SLE) ... criteria of SLE have been recently suggested, like Mahler and Letter AIT test has no problem in the detection of anti-ribosomal P La-He Jearn and Think...
Ngày tải lên: 09/08/2014, 14:21
Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx
... staining pattern [2]. Despite the clearance of the AIT test by the South Korea Food and Drug Administration, to the best of our knowledge this test is not widely used as a screening method – neither ... AIT test represents a sensitive and reliable method for the detection of anti-Rib -P antibodies. A systematic study is mandatory to compare the sensitivity a...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trial" ppt
... this article as: James et al.: Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled ... prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis...
Ngày tải lên: 10/08/2014, 21:24
Báo cáo y học: "A case-series study to explore the efficacy of foot orthoses in treating first metatarsophalangeal joint pain" pot
... al.: A case-series study to explore the efficacy of foot orthoses in treating first metatarsophalangeal joint pain. Journal of Foot and Ankle Research 2010 3:17. Submit your next manuscript to BioMed ... This is in agreement with other authors who have explored the efficacy of variously produced foot o rthoses for other indications [45,46]. Contrary...
Ngày tải lên: 10/08/2014, 21:24
Báo cáo y học: "Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report" doc
... 86 a IU, international normalized ratio; ALT, alanine transferase; AST, aspartate transaminase; ALP, alkaline phosphatase; GGT, g-glutamyl transpeptidase; Br, bilirubin. Cheung et al. Journal of ... have any evidence of urothelial toxicity, such as hematuria, to indicate a failure of mesna in neutralizing the acrolein produced. However, an idiosyncratic drug reaction to ifosfa...
Ngày tải lên: 11/08/2014, 00:23
Báo cáo y học: " Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study" ppsx
... predictors of sustained favorable long-term outcome over a 3-year period. When assessing the association between all baseline measures and sustained favorable long-term outcome, only 9 variables remained ... approval was obtained at each regional site prior to initiation of the study, and the study was conducted in accordance with the ethical principles that h...
Ngày tải lên: 11/08/2014, 15:22
Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf
... (Stage I) and tiny collagen fibers in the lung of rats in the sil- ica+Lv-shCD36 group. Compared to the silica and the sil- ica+Lv-shCD36-NC groups, the number of nodules in the lungs of rats in the ... silencing expression of CD36 inhib- its activation of L-TGF-β1, which results in reduced hydroxyproline, collagen synthesis, and further preve...
Ngày tải lên: 12/08/2014, 14:20
Báo cáo y học: "Nebulised heparin: a new approach to the treatment of acute lung injury" pdf
... without the risk of systemic complications? What is the adequate duration of this therapy? Does the underlying cause of ALI make any difference with regard to this approach? Ultimately, randomized ... begins in the early phases of ALI, how can it be assessed in order to initiate heparin administration as rapidly as necessary? How can dosage of the drug be titrated to...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: "Real-time reverse-transcription PCR in the diagnosis of influenza A (H1N1)v in intensive care unit adult patients" pdf
... influenza A (H1N1)v virus in nasopharyngeal swabs on intensive care unit (ICU) admission was negative in four patients (12.5%) who later had a positive PCR result in respiratory secretions obtained at ... as samples were not tested in parallel by a different assay yielding a posi- tive result – in fact, RT -PCR, which was used at participating centers, is curre...
Ngày tải lên: 13/08/2014, 19:20