Báo cáo y học: "Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries" ppsx

Báo cáo y học: " Chemokine blockade: a new era in the treatment of rheumatoid arthritis" ppsx

... thesemolecules in normal homeostasis.Review Chemokine blockade: a new era in the treatment of rheumatoid arthritis?Jasper J Haringman and Paul P TakDivision of Clinical Immunology and Rheumatology, Academic ... migration selectively [20]. In that study a highly specific neutralizing antibody againstIL-8 was administered in several types of acuteinflammatory disease, including lipopolysaccharide/IL-1induced ... (pro)inflammatory mediators suchas cytokines and matrix metalloproteinases [3]. Increasedexpression of inflammatory chemokines has been found in many inflammatory disorders, including hepatic...

Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx

... [ 42] but also as co-stimulators of cells of the adaptive immune system. TLR -2 engagement therefore influences the differentiation of T cells not only by the activation of DCs (indirect pathwayFigure ... Toll-like receptor (TLR) -2 on pre-activated T cells in pathogen-induced chronic inflammatory joint diseasesExplanation for the involvement of Toll-like receptor (TLR) -2 on pre-activated T cells in pathogen-induced ... the T cell receptor. T/ TEinflamed joint activated andmemory T cells can passendothelial barriersTLR ligandscan activate T cells independent of antigenic specificityrelease of inflammatory...

Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt

... at1 year and 2 years of 96% and 89% compared withViewpointCold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertensionFrances C HallUniversity of ... processesunderlying RP and PAH contribute to the familiar pattern of skin, renal and gastrointestinal pathology. The emergence of effective and conveniently administered therapy for PAHincreases the importance ... cell dysfunction is characterised bydecreased production of the vasodilators nitric oxide and prostacyclin, and by enhanced release of endothelin-1.Endothelial cell dysfunction influences the...

Báo cáo y học: "MLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis" pps

... articleMLN51 and GM-CSF involvement in the proliferation of fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritisJinah Jang1, Dae-Seog Lim2, Young-Eun Choi1, Yong Jeong2, ... many kinds of different cytokines and growth factors in the RA joint microenvironments. To identify factors having aneffect on the growth of RA FLSs, we investigated the inflam-matory cytokines ... RA.IntroductionSynovial tissue from healthy individuals consists of a singlelayer of synovial cells without infiltration of inflammatory cells. In rheumatoid synovial tissue, lymphocytes and...

Báo cáo y học: "Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity" pdf

... measuring sulphatedglycosaminoglycans (S-GAGs) are available, these assays do not distinguish between synthesis and degradation of the pro-teoglycans [19]. Furthermore, they do not distinguish ... level of IGF-induced collagen II synthesisafter 11 days of cytokine treatment and no IGF-induced colla-gen II synthesis after 17 days of cytokine treatment (Figure2b).Interestingly, under the ... completeanswer but hopefully add a piece of the highly complicatedpuzzle. Most interestingly, aggrecanase- mediated aggrecan degradation was virtually absent at the end of the study period;instead, the...

Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps

... (MPR) for any urate-lowering drug (ULD) useThe distribution of the medication possession ratio (MPR) for any urate-lowering drug (ULD) use. The distribution of the study population in terms of ... dis-pensings of NSAIDs, colchicine and glucocorticoids in the 30days prior to and including the date of the first ULD dispens-ing.Analyses The characteristics of the study population were examined. The ... Musculoskeletal and Skin Diseases. The content is solely the responsibility of the authors and does not necessarily rep-resent the official views of the National Institute of Arthritis and Muscu-loskeletal...

Báo cáo y học: "AIT test has no problem in the detection of anti-ribosomal P" ppsx

... qualitycontrol program run by the Korean Society of LaboratoryMedicine [3]. In 1999 and 2007, reports of antinuclearantibody test using the IT-1 cell line on 208 and 588systemic lupus erythematosus (SLE) ... criteria of SLE have been recently suggested, like Mahler andLetterAIT test has no problem in the detection of anti-ribosomal PLa-He Jearn and Think-You KimDepartment of Early Arthritis/Laboratory ... respectively,showed a 100% positive rate that proved an exceptionalimprovement in the test performance [4,5]. Furthermore, the AIT test can indirectly help in the diagnosis of SLE using the microtubule...

Báo cáo y học: " AIT test has no problem in the detection of anti-ribosomal P – authors’ response" docx

... staining pattern [2]. Despite the clearance of the AIT test by the South Korea Food and Drug Administration, to the best of our knowledge this test is not widely used as ascreening method – neither ... AIT test represents a sensitiveand reliable method for the detection of anti-Rib -P antibodies.A systematic study is mandatory to compare the sensitivityand specificity of the AIT test for the ... T -Y: AIT test has no problem in the detection of anti-ribosomal P. Arthritis Res Ther 2009, 11:407.2. Mahler M, Ngo JT, Schulte-Pelkum J, Luettich T, Fritzler MJ:Limited reliability of the indirect...

Báo cáo y học: "Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trial" ppt

... this article as: James et al.: Heel raises versus prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled ... prefabricated orthoses in the treatment of posterior heel pain associated with calcaneal apophysitis (Sever’s Disease): study protocol for a randomised controlled trialAlicia M James1*, Cylie ... required.Thisstudyaimstocomparetwoclinicallyapplied treatment options for the management of posterior heel pain associated with the clinical diagnosis of calcaneal apophysitis. Method Study DesignThis is a factorial randomised controlled trial;...

Báo cáo y học: "A case-series study to explore the efficacy of foot orthoses in treating first metatarsophalangeal joint pain" pot

... al.: A case-series study to explore the efficacy of foot orthoses in treating first metatarsophalangeal joint pain.Journal of Foot and Ankle Research 2010 3:17.Submit your next manuscript to BioMed ... This is in agreementwith other authors who have explored the efficacy of variously produced foot o rthoses for other indications[45,46]. Contrary to the hypothesised mode of action[16], the exploratory ... endpoint.Gait AnalysisAt the 8 wee k review, 1 0 participants were invited to participate in the 2ndstage of the study exploring the Figure 1 Type of foot ort hoses used in the s tudy. This shows the pre-fabricated...

Báo cáo y học: "Acute liver toxicity with ifosfamide in the treatment of sarcoma: a case report" doc

... 86 a IU, international normalized ratio; ALT, alanine transferase; AST, aspartate transaminase; ALP, alkaline phosphatase; GGT, g-glutamyl transpeptidase; Br, bilirubin.Cheung et al. Journal of ... haveany evidence of urothelial toxicity, such as hematuria, toindicate a failure of mesna in neutralizing the acroleinproduced. However, an idiosyncratic drug reaction to ifosfamide may also ... related alkylatingagent, cyclophosphamide, are both activated in the liver by P450 oxidases, they are uncommon hepatic toxins[7], and it is suggested they can be used safely in patients with abnormal...

Báo cáo y học: " Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study" ppsx

... predictors of sustained favorable long-term outcome over a 3-year period. When assessing the associationbetween all baseline measures and sustained favorable long-term outcome, only 9 variables remained ... approval was obtained ateach regional site prior to initiation of the study, and the study was conducted in accordance with the ethicalprinciples that have their originintheDeclarationofHelsinki ... 11:143http://www.biomedcentral.com/1471-244X/11/143Page 2 of 12 RESEARCH ARTICLE Open Access Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational studyGebra B Cuyún Carter*,...

Báo cáo y học: "Silencing CD36 gene expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the rat" pdf

... (StageI) and tiny collagen fibers in the lung of rats in the sil-ica+Lv-shCD36 group. Compared to the silica and the sil-ica+Lv-shCD36-NC groups, the number of nodules in the lungs of rats in the ... silencing expression of CD36 inhib-its activation of L-TGF-β1, which results in reducedhydroxyproline, collagen synthesis, and further preven-tion of the development of lung fibrosis. These ... expression results in the inhibition of latent-TGF-β1 activation and suppression of silica-induced lung fibrosis in the ratXin Wang, Ying Chen, Lina Lv and Jie Chen*Address: Division of Pneumoconiosis,...

Báo cáo y học: "Nebulised heparin: a new approach to the treatment of acute lung injury" pdf

... without the risk of systemic complications? What is the adequate duration of this therapy? Does the underlyingcause of ALI make any difference with regard to this approach? Ultimately, randomized ... begins in the early phases of ALI, how can it be assessed in order to initiate heparin administration as rapidly as necessary? Howcan dosage of the drug be titrated to achieve maximal localeffects ... ‘standard’ care has to be defined in detail in suchsituations, and rigorous control of physiological variables aswell as therapeutic modalities is of the outmost importance[9]. The use of ‘treatment...

Báo cáo y học: "Real-time reverse-transcription PCR in the diagnosis of influenza A (H1N1)v in intensive care unit adult patients" pdf

... influenza A (H1N1)v virus in nasopharyngeal swabs on intensive care unit (ICU) admission was negative in four patients (12.5%) wholater had a positive PCR result in respiratory secretionsobtained at ... as sampleswere not tested in parallel by a different assay yielding a posi-tive result – in fact, RT -PCR, which was used at participatingcenters, is currently the standard method for the diagnosis ... (H1)v assay [2]. The pretestprobability of disease is an important issue. Our findings areconsistent with further series of critically ill patients [3]. In pneumonia, viral load in the nasopharynx...

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