Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf
Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer pdf
... al., Rapid detection of epidermal growth factor
receptor mutations with multiplex PCR and primer extension in lung cancer
Journal of Biomedical Science 2010, 17:37
Lin et al. Journal of Biomedical ... work is properly cited.
Research
Rapid detection of epidermal growth factor
receptor mutations with multiplex PCR and primer
ext...
Tài liệu Báo cáo khoa học: Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase pdf
... gefitinib-responsive lung
cancer was recently examined for mutations, and clus-
tering of mutations was detected in the part of the
gene encoding the ATP-binding pocket. Screening for
such mutations may ... Arteaga CL (2001) Epidermal growth
factor receptor (HER1) tyrosine kinase inhibitor
ZD1839 (Iressa) inhibits HER2 ⁄ neu (erbB2)-over-
expressing breast cancer cel...
Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx
... for
indicating the intrinsic kinase activity of EGFR,
regardless of tissue type.
Results
Ligand-induced transcriptional signatures of
EGFR-WT and L858R in the absence or presence
of EGFR kinase ... YT, Lin YF, Chang WC, Kuo HP et al. (2004)
High frequency of epidermal growth factor receptor
mutations with complex patterns in non-small cell lung
cancers related to...
Báo cáo khoa học: " Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma" docx
... of the sample
exhibiting staining); 2 (21-40% of the sample exhibiting
staining); 3 (41-60% of the sample exhibiting staining); 4
(61-80% of the sample exhibiting staining), and 5 (81-
100% of ... sample exhibiting staining); 3 (41-60% of the sample exhibiting staining); 4 (61-80% of the
sample exhibiting staining), and 5 (81-100% of the specimen stained). The findings o...
Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... regulation of ligand binding affinity in the
receptor [86].
Interestingly, the occurrence of in- frame tandem
duplication of exons 18–25 ⁄ 18–26 in the EGFR gene
results in mutant receptors with duplication ... Ca
2+
⁄ calmodulin-dependent kinase II phospho-
rylates the epidermal growth factor receptor on multi-
ple sites in the cytoplasmic tail and serine 744 with...
Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... expression in a subset of
human lung cancers
To gain further insights into the role of miR-125a-5p
in lung carcinogenesis and to examine the clinical rele-
vance of our findings, we investigated ... cen-
tral role in the etiology and progression of numerous
epithelial malignancies, including lung cancer [4].
Moreover, the function of EGFR mutations in survival...
Báo cáo khoa học: Phosphorylation of Hrs downstream of the epidermal growth factor receptor docx
... role in the trafficking of growth factor/
receptor complexes through early endosomes. Stimulation
of cells with epidermal growth factor (EGF) rapidly leads to
phosphorylation of Hrs, raising the ... Endocytosed
epidermal growth factor (EGF) receptors contribute to the EGF-
mediated growth arrest in A431 cells by inducing a sustained
increase in p21/CIP. Exp. Cel...
báo cáo khoa học: "Sustained complete remission of human epidermal growth factor receptor 2-positive metastatic breast cancer in the liver during long-term trastuzumab (Herceptin) maintenance therapy in a woman: a case report" docx
... remission within six
months of receiving trastuzu mab (Herceptin) in combination with vinorelbine and gemcitabine. The patient
remains in complete remission seven years later and continues to ... M, Cognetti F, Maraninchi D, et al: Randomized phase II trial of the
efficacy and safety of trastuzumab combined with docetaxel in patients
with human epidermal growth fa...
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... that bind to EGFR and
ERBB4 (including betacellulin, heparin-binding EGF
and epiregulin); and (c) neuregulin (NRG) (also known
as heregulin) that binds to ERBB3 and ERBB4.
NRG1 and NRG2 bind to ... Kinetic analysis of epidermal
growth factor receptor somatic mutant proteins shows
increased sensitivity to the epidermal growth factor
receptor tyrosine kinase inhibito...
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... activity of EGFR (EGFR-TKIs), gefiti-
nib and erlotinib, compete with ATP for binding to
the tyrosine kinase pocket of the receptor, thereby
inhibiting receptor tyrosine kinase activity and EGFR
signaling ... off and the cancer cells undergoing apoptosis.
Moreover, EGFR mutations result in repositioning of
critical residues surrounding the ATP-binding cleft of
the tyro...