The Biology of NKT Cells Albert Bendelac - part 4 ppsx

... for Vα 14 NKT cells in IL-12-mediated rejection of tumors. Science 278:1623–26 196. Park SH, Kyin T, Bendelac A, Carnaud C. 2003. The contribution of NKT cells, NK cells, and other γ-chain-dependent ... Campos RA. 20 04. Extravascular T-cell recruitment requires initiation begun by Vα 14 + NKT cells and B-1 B cells. Trends Immunol. 25 :44 1 49 www.annualreviews.org •...

Ngày tải lên: 10/08/2014, 03:20

... by the rar- ity of iGb3 and the dominance of the regioiso- mer Gb3. Furthermore, other than the enzy- matic pathways of synthesis and degradation, little is known about the general biology of iGb3, ... knockin mice. Particularly affected are the presentation of the NKT endogenous lig- and (27) and, consequently, the thymic gen- eration of Vα 14 NKT cells (...

Ngày tải lên: 10/08/2014, 03:20

... TCR CD1d EC RORγt Bcl-xL TCR/iGb3/CD1d SLAM/SLAM? Cortical thymocytes Resident SAP/Fyn PKCθ Bcl-10 NF-κB T-bet IL-15Rβ CD4 CD4 DP DP DN CD4 CD4 DN CD4 DN Vα 1 4- Jα18 CD 24 hi CD69 hi CD 24 lo CD 44 lo NK1.1 – IL -4 CD 24 lo CD 44 hi NK1.1 – IL -4 IFN-γ CD 44 hi NK1.1 + IL -4 IFN-γ Emigrant Figure 4 Thymic NKT cell ... the CD 44 high NK1.1 neg cells produce both IL -4 an...

Ngày tải lên: 10/08/2014, 03:20

... February 2007 12:20 49 . Yamaguchi Y, Motoki K, Ueno H, Maeda K, Kobayashi E, et al. 1996. Enhanc- ing effects of (2S,3S,4R )-1 -O-(α-D-galactopyranosyl )-2 -( N-hexacosanoylamino )-1 ,3, 4- octadecanetriol ... sug- gested a profibrotic role of Vα 24 NKT cells in hepatitis C (85) and the accumulation of non-Vα 24 CD1d-restricted T cells (210). Al- though a specific ro...

Ngày tải lên: 10/08/2014, 03:20

... . In this case the final distance moved is twice the distance moved during the acceleration, as shown in the No S-curve of Figure 3.9. The Partial S-curve The Partial S-curve is more ... required during the period of full acceleration. From this the duration of the maximum acceleration segment of the acceleration profile can be obtained. The final cond...

Ngày tải lên: 10/08/2014, 05:20

... revascularization of hibernat- ing myocardium [47 ,48 ]. This procedure provides relief from heart failure symptoms, improved sur- vival, and important quality -of- life benefit. A comprehensive meta-analysis of ... inducible ventricu- lar tachycardia, cryotherapy was also applied to the edges of the resection (50% of cases). Between development of the surgical principles in 19...

Ngày tải lên: 11/08/2014, 15:20

... essential to add another dimension to the archi- tecture of science buildings. How, for example, might the present-day counterparts of Thomas Midgley Jr. be warned about the fallibility of human intelligence ... clear-headed view of the human predicament in the twenty- first century. John’s professional work, both written and built, is a legacy in the form of a challenge...

Ngày tải lên: 06/07/2014, 14:20

... is important to note that, for the majority of adult-onset, multifactorial genetic Chapter 0 64. The Practice of Genetics in Clinical Medicine (Part 4) Figure 6 4- 2 disorders, testing is purely ... integrated into the practice of medicine. In most cases, however, the discovery of disease-associated genes has greatly outpaced studies that assess clinical outcomes...

Ngày tải lên: 07/07/2014, 01:20

... ratio, i. e. the grip- ping force in relation to the weight of the gripper multiplied by the stroke of the finger, was at 2 .4 J/kg for the short stroke. The next milestone was set by the PGN gripper ... λ 1 - 2 Nm kg 39 Handling: The Underrated Process 1.3 What Are The Main Points of This Book? The following chapters focus on the realization of handling...

Ngày tải lên: 10/08/2014, 04:21