Ophthalmic Drug Delivery Systems - part 9 pps

... Rel, 11 :79 (19 90). 11 . S. D. Klyce and C. E. Crosson. Transport processes across the rabbit corneal epithelium: a review. Curr. Eye Res. 4:323–3 31, 19 85. 12 . A. K. Mitra. Ophthalmic drug delivery. ... octanol-water partition coefficients. J. Pharm. Sci. 67:786–788, 19 78. 16 . M. M. Narurkar and A. K. Mitra. Prodrugs of 5-iodo-2 0 -deoxyuridine for enhanced ocular transport. Ph...

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... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiologyoftheeyeand surroundingtissue,ocularpharmacokineticsisconsiderablymoredifficult todescribeandpredictthanitssystemiccounterpart.Thetaskisfurther complicatedbythevariousformulations,routes,anddosingregimenstypi- callyencoun...

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... calculated at 4, 12, and 24 hours after injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, ... examinedthetransportkineticsofascorbateusingtherecentlydeveloped consciousanimalmodelwithmicrodialysissamplingofaqueoushumor. Microdialysisprobeswereplacedintheanteriorchamberofon...

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... applied drugs in the rabbit. Pharm. Res. 15: 1882–1887, 1998. 50 . Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... Animal Effect 2-Phenylethanol 0 .5% Tilisolol, FD-4, FD- 10 Rabbit Enhanced Papp 2.7 times for tilisolol, 5. 6 times for FD-4, and 4.8 times for FD-10 Paraben 0.04% Tilisolo...

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... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per- meation of drug across the conjunctiva and sclera and may contribute sig- nificantly ... of the eye, Biomaterials., 21 :64 9 66 5. 131. Peyman, G. A., and Ganiban, G. J. (1995). Review: Delivery systems for intraocular routes, Adv. Drug Delivery Rev., 16: 107–123. 13...

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... analogue, 1- desamino -8 - D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO-2, Int. J. Pharm., 64: 181 . 43. Amidon, G. L., Sinko, P. J., Hu, M., and Leesman, G. D. (1 989 ). ... rhodop- sin mutation were protected from apoptosis by recombinant adeno- associated virus-mediated production of fibroblast growth factors fgf-2, fgf-5, and fgf- 18 (30,31), while len...

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... S. G. ( 199 9). Stable transgene expression in rod photoreceptors after recombinant adeno-associated virus-mediated gene transfer to monkey retina. Proc. Natl. Acad. Sci. USA, 96 (17) :99 20 99 25. 130. ... ( 199 6). Phosphorothioate-modified oli- godeoxyribonucleotides, III. NMR and UV spectroscopic studies of the Rp- Rp, Sp-SP, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diaster- eome...

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... pharmaceu- tical drug product will be essential. The commercial consideration for development of an ophthalmic drug delivery system is not limited to new therapeutic agents. Many existing ophthalmic drugs ... will vary with the particular dru g and the novelty of the particular delivery system. The approach of one company in establishing the safety/toxicity profile of ophthalmic...

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... intraocular sur- gery. Ophthalmology 98:227–228, 1991. 24. Peyman, G. A., and Schulman, J. A. Intravitreal drug therapy. In: Intravitreal Surgery. Norwalk: Appleton-Century-Crofts, pp. 40 7 45 5. 25. ... Similarrelationshipsbetweenretinalpermeability,vitreousdiffusivity,mole- cularweight,andhalf-lifehavebeenshownbyMaurice(32,36).Withinthe rangestudied,half-lifeisinverselydependentonthevitr...

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... ( 199 6). Phosphorothioate-modified oli- godeoxyribonucleotides, III. NMR and UV spectroscopic studies of the Rp- Rp, Sp-SP, and Rp-Sp duplexes, [d(GGSAATTCC)]2, derived from diaster- eomeric O-ethyl ... cationic lipid-protamine-DNA (LPD) complexes. Gene Ther., 4 (9) : 891 90 0. 176. Li, S., Rizzo, M. A., Bhattachrya, S., and Huang, L. ( 199 8). Characterization of cationic lipid-protamine-DNA...

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... pharmaceu- tical drug product will be essential. The commercial consideration for development of an ophthalmic drug delivery system is not limited to new therapeutic agents. Many existing ophthalmic drugs ... activity of phosphorothio- ate antisense oligonucleotides. Mol. Pharmacol. 41 :102 3 103 3. 180. O. Zelphati and F. C. Szoka, Jr. (1996). Intracellular distribution and mechan-...

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