Ophthalmic Drug Delivery Systems - part 4 doc

... calculated at 4, 12, and 24 hours after injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, ... Inc. examinedthetransportkineticsofascorbateusingtherecentlydeveloped consciousanimalmodelwithmicrodialysissamplingofaqueoushumor. Microdialysisprobeswereplacedintheanteriorchambe...

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... Animal Effect 2-Phenylethanol 0.5% Tilisolol, FD -4 , FD- 10 Rabbit Enhanced Papp 2.7 times for tilisolol, 5.6 times for FD -4 , and 4. 8 times for FD-10 Paraben 0. 04% Tilisolol, FD -4 , FD- 10 Rabbit ... applied drugs in the rabbit. Pharm. Res. 15:1882–1887, 1998. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4- phenylazobenzyloxycarbonyl-L-Pro-L...

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... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per- meation of drug across the conjunctiva and sclera and may contribute sig- nificantly ... Routes of delivery: case studies. (7). Ocular delivery of peptide and protein drugs, Adv. Drug Delivery Rev., 8:331–339. 81. Chiou, G. C. Y. (19 94) . Systemic delivery of polyp...

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... Absorption of vasopressin analogue, 1- desamino-8-D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO-2, Int. J. Pharm., 64: 181. 43 . Amidon, G. L., Sinko, P. J., Hu, ... Pharm. Exp. Ther., 249 : 249 . 80. Ahmed, I., and Patton, T. F. (1985). Importance of the noncorneal absorption route in topical ophthalmic drug delivery, Invest. Ophthalmol. Vis. Sci., 2...

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... intraocular sur- gery. Ophthalmology 98:227–228, 1991. 24. Peyman, G. A., and Schulman, J. A. Intravitreal drug therapy. In: Intravitreal Surgery. Norwalk: Appleton-Century-Crofts, pp. 40 7 45 5. 25. ... Inc. Similarrelationshipsbetweenretinalpermeability,vitreousdiffusivity,mole- cularweight,andhalf-lifehavebeenshownbyMaurice(32,36).Withinthe rangestudied,half-lifeisinverselydependentonth...

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... including polymer -drug complex sys- tems, erodible microspheres, responsive particulates, in situ gelling systems, ion-exchange systems, and nanoparticles (15). B. Local Injectable Systems When the ... PECL nanoparticles for carteolol. It was concluded that the drug entrapped in the oily core is more available for corneal absorption. 3 H-Labeled hydrocortisone-17-butyrate-21-propiona...

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... Mucoadhesive Polymers in Ophthalmic Drug Delivery 40 9 ThomasP.Johnston,ClaptonS.Dias,HemantAlur, andAshimK.Mitra 14. Microparticles and Nanoparticles in Ocular Drug Delivery 43 7 Murali K. Kothuri, ... of a series of 5 0 -ester prodrugs of 5-iodo-2 0 -deoxyuridine. Pharm. Res. 5:7 34 737, 1988. 10 Macha et al. Copyright © 2003 Marcel Dekker, Inc. Ophthalmic Drug Delivery...

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... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiologyoftheeyeand surroundingtissue,ocularpharmacokineticsisconsiderablymoredifficult todescribeandpredictthanitssystemiccounterpart.Thetaskisfurther complicatedbythevariousformulations,routes,anddosingregimenstypi- callyencoun...

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... adenovirus encoding brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized ... myocardium. Nature, 41 0(6829):701–705. 48 . Brown, J. M., Weissman, I. L., and Shizuru, J. A. (2001). Immunity to infec- tions following hematopoietic cell transplantation. Curr. Opin. Immun...

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... 94: 12 744 –12 746 . 99. D. Pogocki and C. Schoneich. (2000). Chemical stability of nucleic acid- derived drugs. J. Pharm. Sci., 89 :44 3 45 6. 100. I. Jaaskelainen, J. Monkkonen, and A. Urtti. (19 94) . ... for gene delivery in vitro and in vivo. Adv. Drug Deliv. Rev., 24: 265– 271. 84. C. Plank, W. Zauner, and E. Wagner. (1998). Application of membrane-active peptides for drug and ge...

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