Ophthalmic Drug Delivery Systems - part 2 pdf

... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiologyoftheeyeand surroundingtissue,ocularpharmacokineticsisconsiderablymoredifficult todescribeandpredictthanitssystemiccounterpart.Thetaskisfurther complicatedbythevariousformulations,routes,anddosingregimenstypi- callyencoun...

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... intraocular sur- gery. Ophthalmology 98 :22 7 22 8, 1991. 24 . Peyman, G. A., and Schulman, J. A. Intravitreal drug therapy. In: Intravitreal Surgery. Norwalk: Appleton-Century-Crofts, pp. 407–455. 25 . Speaker, ... Sci. 26 :698–710, 1985. 17. Lund-Andersen, H., Krogsaa, B., and Larsen, J. Calculation of the perme- ability of the blood-retinal barrier to fluorescein. Graef. Arch. Clin. Ex...

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... of a series of 5 0 -ester prodrugs of 5-iodo -2 0 -deoxyuridine. Pharm. Res. 5:734–737, 1988. 10 Macha et al. Copyright © 20 03 Marcel Dekker, Inc. Ophthalmic Drug Delivery Systems Second Edition, ... forms (21 ,22 ). Instilled dose leaves the precorneal area within 5 minutes of instillation in humans (21 ,23 ). The natural tendency of the cul-de-sac is to reduce its fluid volume t...

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... at 4, 12, and 24 hours after injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, ... Ophthalmol. 22 8:461–466, 1990. 36. Tsukahara, Y., and Maurice, D. M., Local pressure effects on vitreous kinetics. Exp. Eye Res. 60:563–574, 1995. Drug Distribution in Vitreous Humor 22 1...

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... applied drugs in the rabbit. Pharm. Res. 15:18 82 1887, 1998. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... hydrocortisone/ hydroxypropyl-beta-cyclodextrin solution for ocular drug delivery. Int. J. Pharm. 156 :20 1 20 9, 1997. 26 . Jarho, P., Jarvinen, K., Urtti, A., Stella, V....

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... applied ophthalmic drugs, Surv. Ophthalmol., 26 :20 7 21 8. 88. Mikkelson, T. J. (1984). Review: Ophthalmic drug delivery, Pharm. Tech., 8:90–98. 89. Lee, V. H. L. (1985). Review: Topical ocular drug delivery recent ... researchers. Br. J. Ophthalmol., 20 :21 3 22 9. 22 . Erlanger, G. (1939). Iontophoretic medication in ophthalmology. Theoretic and practical aspects. Arch. Phys....

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... rhodop- sin mutation were protected from apoptosis by recombinant adeno- associated virus-mediated production of fibroblast growth factors fgf -2 , fgf-5, and fgf-18 (30,31), while lens epithelium-derived ... Atursson, P. (1990). Absorption of vasopressin analogue, 1- desamino-8-D-arginine-vasopressin (dDAVP), in human intestinal epithelial cell line, CaCO -2 , Int. J. Pharm., 64:181. 43....

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... Science, 28 7(5460) :20 32 20 36. 53. Ahmed, I., Tang, L., and Pham, H. (20 00). Identification of neural progeni- tors in the adult mammalian eye. Biochem. Biophys. Res. Commun., 27 0 (2) :517– 521 . 54. ... scavenger, N-tert-butyl- ( 2- sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized RGCs, indicating the clinical usefulness of the approach for treating RGCs follo...

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... Blood, 83:677–6 82. 25 2. M. F. Kubik, A. W. Stephens, D. Schneider, R. A. Marlar, and D. Tasset. (1994). High-affinity RNA ligands to human alpha-thrombin. Nucleic Acids Res., 22 :26 19 26 26. 25 3. V. Nobile, ... 26 4:650–666. 24 2. L. R. Paborsky, S. N. McCurdy, L. C. Griffin, J. J. Toole, and L. C. Leung. (1993). The single-stranded DNA aptamer-binding site of human thrombin. J. Biol. Ch...

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