Intraocular Drug DelIvery - part 3 ppt

... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1985 (56). The formula of anecortave acetate is 4,9(11)-pregnadien-17,21-diol -3 , 20-dione-21-acetate. ... Vitreous volume (mL) Aqueous flow (mL/min) Rabbit 1.4–1.7 3. 6 Cat 2.4 13. 0 Dog 3. 2 Monkey 3. 0–4.0 3. 0 Man 3. 9–5.0 2.5 3. 0 Source: From Ref. 32 . Intravitreal Antimicrobials 89 tre...

Ngày tải lên: 09/08/2014, 20:22

... Invest Ophthalmol Vis Sci 19 93; 34 :522– 530 . 138 . Steffansen B, Ashton P, Buur A. Intraocular drug delivery. In vitro release studies of 5-Fluorouracil from N-1 alkoxycarbonyl prodrugs in silicone oil. ... phosphoinositide 3 kinase (PI3-K) ( 43, 44). PI3-K, in turn, activates a serine–threonine protein kinase, Akt, that phosphorylates Bad (45–47) and promotes its associati on wit...

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... 2.5 I2 3. 8 2 .3 I3 4.2 2.7 Average 4.8 Æ 0. 23 2.9 Æ 0.15 <0.0001 1489 S1 5 .3 3.5 S2 7.5 3. 3 S3 7.5 4.0 I1 5.5 3. 7 I2 4.5 3. 2 I3 5 .3 2.7 Average 5.9 Æ 0.0.29 3. 4 Æ 0.14 <0.0001 Abbreviations: ONL, ... Effect of NT-501 on Photoreceptors of rcd1 Dogs Animal # Retina area à Photoreceptor ONL p-value ECT-CNTF treated Not treated 1485 S1 5.5 3. 0 S2 5.8 2.7 S3 6.0 4.0 I1 4.0...

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... time. Circulation 1966; 33 :30 2 31 6. 31 . Allen TM. Liposomes. Opportunities in drug delivery. Drugs 1997; 54(suppl 4):8–14. 32 . Mayhew E, Ito M, Lazo R. Toxicity of non -drug- containing liposomes ... targeted drug delivery to selective areas of the retina. Invest Ophthalmol Vis Sci 1991; 32 : 235 1– 235 6. 20. Bressler NM, Bressler SB, Fine SL. Age-related macular degeneration...

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... . 32 8 Diagnosis of CMV Retinitis . . . . 33 0 Treatment of CMV Retinitis . . . . 33 0 Systemic Anti-CMV Therapy . . . . 33 1 Local Modes of Intraocular Drug Delivery . . . . 33 3 Intravitreal Drug ... Spectrum . . . . 35 0 Antimicrobial Therapy . . . . 35 0 Injection of Intraocular Corticosteroids . . . . 35 2 Prognosis . . . . 35 3 Summary . . . . 35 3 References . . . ....

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... rabbit. Ophthalmology 1986; 93: 133 – 139 . 62. Burstein NL, Leopold LH, Bernacchi DB. Trans-scleral iontophoresis of gentamicin. J Ocul Pharmacol 1985; 1 :36 3 36 8. 63. Yoshizumi MO, Cohen D, Verbukh ... 93: 839 – 43. 2. Kimura H, Ogura Y. Biodegradable polymers for ocular drug delivery. Ophthalmologica 2001; 215:1 43 155. 3. Kunou N, Ogura Y, Hashizoe M, Honda Y, Hyon S-H, Ikada Y. C...

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... Society–USA panel. Am J Ophthalmol 1999; 127 :32 9 33 9. 38 . Browning DJ. Dislocated ganciclovir implant from use of a nylon fixation suture. Retina 20 03; 23: 7 23 724. 39 . Lim JI, Wolitz RA, Dowling AH, Bloom ... Ehringer B. Passage of drugs through different intraocular microdialysis mem- branes. Graefes Arch Clin Exp Ophthalmol 1995; 233 :31 37 . 49. Waga J, Ohta A, Ehinger B. Intra...

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... macular degeneration: twelve-month clinical outcomes. Ophthalmology 20 03; 110: 237 2– 238 3; Discussion 238 4– 238 5. 59. Hagedorn M, Bikfalvi A. Target molecules for anti-angiogenic therapy: from basic research ... resorption, and downregulate inflam- matory mediators [including interleukin (IL )-5 , IL-6, IL-8, prostaglandins, inter- feron-gamma (IF-g), tumor necrosis factor-alpha]. Cort...

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... Ophthal- mol 2004; 138 (1):158–160. 34 . Bakri SJ, Beer PM. The effect of intravitreal triamcinolone acetonide on intraocular pressure. Ophthalmic Surg Lasers Imaging 20 03; 34 (5) :38 6 39 0. 35 . Detry-Morel ... study period Follow-up period (yr)% No. % No. % No. CVOS 19 10 59 31 22 12 53 2 BVOS 37 13 46 16 17 6 35 3 Abbreviations: CVOS, Central Vein Occlusion Study; BVOS, Branc...

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... 227, 234 , 250, 299, 30 9 5-Fluorouracil (5-FU), 17, 2 83, 285 Fluoroquinolones, 92 Fomivirsen, 33 3 33 5 Food Drug and Cosmetic Act (FD&C Act), 59 Foscarnet, 32 9 33 4, 34 0 Free radicals, 43, 45–46 Fundus, ... 15, 48, 33 2, 34 1 bleb-related, 34 8 causes of, 34 9 34 8 definition of, 34 9 management of, 14 occurrence, 34 9 presentation of, 34 9 treatment outcome, 35 3 Endoth...

Ngày tải lên: 09/08/2014, 20:22