3 drug delivery and induction neoadjuvant chemotherapy

... patients at six points: before treatment and at the beginning, in the middle of and at the end of RT and at and weeks after the completion of RT By using meticulous handling procedure, the blood samples ... (range: 45-66 Gy) and the median fraction size was 1.8 Gy (range: 1.8-3 Gy) Follow up and the definition of RP The patients visited the hospital for follow-up at weeks and 1, 2, and months after ... Chest X-rays were performed at every follow-up visit and chest CT was done at 1, and months after RT We evaluated the symptoms and signs of RP and the radiological changes upto at least months after...

Ngày tải lên: 09/08/2014, 10:20

... neurofibrillary matrix and rosettes, mitotic activity, and presence of necrosis or calcifications The grading system is somewhat subjective and sampling dependent (absent a complete resection) and its reproducibility ... between the ages of 40 and 70 years old (mean age was 53 years, SD of 18) The majority of cases were treated with both surgery and radiotherapy (61%), were white with 55% male and a primary tumor ... (surgery and radiotherapy, surgery only, radiotherapy only, and neither surgery nor radiotherapy) (p < 0.01) The percentage of cases surviving five years by treatment modality was: 73% for surgery and...

Ngày tải lên: 09/08/2014, 09:20

... For the entire group, LRR and DM rates were 7% and 20%, respectively, and years actuarial DFS and OS rates were 73.6% and 81.9%, respectively Differences between RT and no-RT groups were statistically ... months for the fourth and fifth years, and annually after years Chest X-ray and liver sonography were requested every months for the first years and annually for the fourth and fifth years Whole ... extracapsular extension, lymphatic, vascular and perineural invasion, and ratio of involved nodes/ dissected nodes), and treatment-related factors (PMRT, chemotherapy and hormonal therapy) were analyzed...

Ngày tải lên: 09/08/2014, 09:20

... University of Texas M.D Anderson Cancer Center, Houston, Tex., USA Growth factors and cytokines are substances that regulate cell growth and proliferation, and maintain architectural and functional tissue ... new understandings into the field of gene functioning and subcellular pathways Cancer is now considered as a multifactorial and multistep process leading to alteration of oncogenes and antioncogenes ... each drug for any change in indications and dosage and for added warnings and precautions This is particularly important when the recommended agent is a new and/ or infrequently employed drug All...

Ngày tải lên: 28/03/2014, 11:20

... Tissue Avoidance Table and Figure summarize the mean D5 and V40 values for the bladder, SB, and rectum IMRT planning produced significantly lower D5 and V40 values for the bladder and the SB (p < 0.05) ... Carpenter for editorial assistance, and Arantxa Zubiria y Charo Irigoyen for technical contribution Authors’ contributions JA and MM: idea and concept LA and LIR: design and development of study LIR: ... vs f3DCRT and IMRT vs c3DCRT and the differences were considered as statistically significant at the p ≤ 0.05 level Results Target Coverage and Target Dose Distribution The c3DCRT and f3DCRT...

Ngày tải lên: 09/08/2014, 08:22

... XVI, Crawley, UK) For imaging the head -and- neck and brain tumor patients, we used the following parameters: 100 kVp, S20 collimator and F0 filter, total 65 mAs and a high-resolution reconstruction ... tumor and some normal structures of the three patients in the planning CT data sets and the first CBCT data sets The differences of the dose to tumor and some normal tissues were within 1% and ... head -and- neck cases included two natural killer/T-cell (NK/T) lymphoma cases and one nasopharyngeal carcinoma (NPC) case For all patients, conventional CT was acquired with slice thickness of mm and...

Ngày tải lên: 09/08/2014, 08:23

... MJC and KHC took care of patients HCT, NSC and HJT made the treatment planning and carried out all plans comparisons and evaluations DYCH and YJ C participated in manuscript preparation and study ... treatment techniques A, D and G showed the isodose axial, coronal and sagittal views for coplanar IMRT plan respectively B, E and H were the isodose axial, coronal and sagittal views for noncoplanar ... manuscripts, and to publish them Authors' contributions All authors read and approved the final manuscript CHH, CYL and PWS carried out all CT evaluations, study design, target delineations and interpretation...

Ngày tải lên: 09/08/2014, 08:23

... planning and treatment times were similar using conventional techniques versus IMRT [16] Our study expands on the previous one from a planning standpoint by also including a 3D plan comparison and ... manuscript and revisions OC - Contributed to writing of manuscript and concept JM - Performed physics plans and assisted with manuscript NL - Concept of paper, contributed in writing manuscript and ... lesions) The CTV for each plan consisted of the larynx (false and true vocal cords, anterior and posterior commissure, arytenoids and aryepiglottic folds) as well as the subglottic region, extending...

Ngày tải lên: 09/08/2014, 09:20

... external genitalia/perineal skin (penis and scrotum for men and vulva for women), iliac crests, and femoral heads For bowel and bladder, a second volume was created and defined as the considered organ ... mean: Dose mean a the difference between RA2 and IMRT is significant We reported DVH results for one patient in figures 2, and Monitor Units and Delivery time The IMRT plans required a mean of ... medium and integral body doses [15,30] Conclusion Compared to IMRT, RapidArc provides an equivalent coverage of PTV and OAR sparing while reducing the number of MU and the treatment time delivery...

Ngày tải lên: 09/08/2014, 09:20

... Southern Switzerland, Bellinzona, Switzerland Authors’ contributions UM carried out the study conception and design and drafted the manuscript LC carried out the study conception and design and drafted ... collection and analysis, GN performed data collection and analysis, AC performed data collection and analysis, EV performed data collection and analysis, SS performed data collection All authors read and ... in complete surgical remission after induction chemotherapy: a randomized, controlled, clinical trial comparing whole abdominal radiotherapy, chemotherapy, and no further treatment Int J Gynecol...

Ngày tải lên: 09/08/2014, 09:20

... evaluated weekly for acute GI and GU toxicities during the RT Symptoms and treatment were recorded on the chart We retrospectively reviewed these charts and graded acute GI and GU toxicities by the ... Commission on Radiation Units and Measurements (ICRU) No 50 recommendations [26] The clinical target volume (CTV) was defined as pelvic lymph nodes and primary tumor region and was contoured on individual ... received 5-Flourouracil (1000 mg/m2 continuous infusion days - 4) and Mitomycin-C (10 mg/m2 on day 1) during the first and last week of RT, and those with bladder cancer received weekly Cisplatin (40...

Ngày tải lên: 09/08/2014, 09:20

... melanoma and RCC lesions Page of We generated TCP graphs using both SFED and BED (Figure 2) Both SFED and BED had a strong coefficient of determination to predict future outcomes (SFED R = 0.999 and ... study found equivalence between 27 Gy in fractions and 40 Gy in fractions, and an RTOG study likewise found equivalence between 50 Gy in 20 fractions and 32 Gy in fractions in terms of response rate ... and regularly in patients undergoing chemotherapy for other sites of disease The lesions were contoured using dedicated medical image analysis software (MIMvista®, MIM Software, Inc., Cleveland,...

Ngày tải lên: 09/08/2014, 09:20

... and 1.8-Gy daily fractions The intended targeted tissues included the gross tumor and nodal disease, which were contoured based on the CT simulation scan, mesorectum, and the internal iliac and ... reviewed and deemed clinically acceptable by both a gastrointestinal clinical physicist and radiation oncologist Plan evaluation and statistical tools Evaluated volumes included the PTV and relevant ... carried out the study conception and design and drafted the manuscript MBP performed treatment planning TMB and SB performed physics checks/plan evaluation Patient accrual and radiation field design...

Ngày tải lên: 09/08/2014, 09:20

... 5.5 months for time to progression The 1-year and 2-year local control and overall survival rates for all patients were 51.2% and 30.7%, and 48.5% and 16.1%, respectively Overall, the MST for ... 1- and 3-year local failure-free survival rates were 70% and 51% for the SRS group and 91% and 83% for the SRT group (P = 0.003) Although the overall survival rates were similar (66% in SRS and ... of patients with recurrent and second primary tumors, limited and advanced tumors, curative and palliative treatment, squamous cell carcinoma and other histologies, and variable treatment strategies...

Ngày tải lên: 09/08/2014, 09:21

... the associations between tTATI and s-TATI concentrations, before and after RT, and clinicopathological parameters, including s-CEA and s-creatinine Classification and regression tree (CRT) analysis ... tumour tissue and normal mucosa before and after radiotherapy Box plots showing TATI expression levels in tumour tissue before and after RT (A), and in normal mucosal tissue before and after RT ... in patients receiving adjuvant chemotherapy compared to patients not receiving adjuvant chemotherapy (data not shown) Association between TATI in tissue and serum and clinicopathological characteristics...

Ngày tải lên: 09/08/2014, 09:21

... the pre-treatment GI and genitourinary (GU) morbidity and acute and late toxicity of the first 39 patients after a median follow-up of 29 months Methods Patient selection and characteristics A ... score, prostate-specific antigen (PSA) level, CT and/ or MRI of the abdomen and pelvis and a total-body bone scan When clinically indicated a chest x-ray and/ or thoracic CT was performed Based on these ... assess coverage, homogeneity and conformity of the PTV the V95 (percentage of PTV receiving at least 95% of dose, corresponding to 76 Gy) and the Dmax and Dmin (maximum and minimum dose within the...

Ngày tải lên: 09/08/2014, 09:22

... withdrawn and the primary tumor alone is treated to 79,2 Gy V20 right and left lung and V25 both lungs is 49%, 22% and 26%, respectively V50 for the heart is 2% Peripheral tumor located lateral and ... MLC coverage and/ or to allow the insertion of a motorized wedge, all combinations of possibly adjacent jaws (x1/x2, x1/y1, x1/y2, y1/x2 and y1/y2) have to be tested On a monthly basis and after ... lobe, 5,5 cm ∅; enlarged PET-positive hilar, subcarineal and bilateral mediastinal nodes A Scheme; position of junction plane and upper and lower borders, doses (Gy) B Treatment plan single fraction...

Ngày tải lên: 09/08/2014, 10:20

... stage II and III MPM, and the authors reported accuracy of 77% for CT, 86% for PET, 80% for Magnetic Resonance Imaging (MRI), and 100% for PET-CT in patients with stage II disease, and accuracy ... (BP and checked by ET) with specific experience in MPM cancer treatment on the CT and integrated PET-CT images The GTV was defined as the volume of macroscopic primary tumor and involved hilar and ... margin, and PTV2 was created with a 1-cm margin to the GTV All volumes were defined again on integrated PET-CT images Lungs (right and left separately), liver, heart, esophagus, and kidneys (right and...

Ngày tải lên: 09/08/2014, 10:20

... type, and extent of disease, initial Karnofsky score, dose and fractionation radiotherapy schedule, surgery, chemotherapy and RPA class, showed in table The supportive care (oral prednisone) and ... randomized Japanese trial, JROSG 99-1, patients were randomly assigned to SRS alone, versus WBRT and SRS The actuarial month freedom from new brain metastases was 48% in the SRS alone arm, and ... prednisone) and neurological status was not evaluated Chemotherapy was Results The overall survival rate in 1, and years was 24%, 9.4%, and 4.3%, respectively (figure 1) Three patients were alive...

Ngày tải lên: 09/08/2014, 10:21