Intraocular Drug DelIvery - part 2 ppt

... and ZO-1 in cultured cells. J Biol Chem 20 02; 27 7 :27 ,757 27 ,764. 33. Cordenonsi M, D’Atri F, Hammar E, et al. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO -2 , ZO-3, ... Chem 20 00; 27 5 :29 ,816 29 , 822 . 66. Traweger A, Fang D, Liu YC, et al. The tight junction-specific protein occludin is a func- tional target of the E3 ubiquitin-protein ligase it...

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... oid (anti-inflam matory) or mineralocor ticoid (salt retaining) activity, and was intro duced in 1985 (56). The formula of anecortave acetate is 4,9(11)-pregnadien-17 ,21 -diol-3 ,20 -dione -2 1 -acetate. ... anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degen- eration. Retina 20 02; 22 :143–1 52. 18. Folkman J, Klagsbrun M. Angiogenic factors. Scie...

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... area à Photoreceptor ONL p-value ECT-CNTF treated Not treated 1485 S1 5.5 3.0 S2 5.8 2. 7 S3 6.0 4.0 I1 4.0 2. 5 I2 3.8 2. 3 I3 4 .2 2.7 Average 4.8 Æ 0 .23 2. 9 Æ 0.15 <0.0001 1489 S1 5.3 3.5 S2 7.5 3.3 S3 ... 16:397–400. 21 . Yerxa BR, Sabater JR, Davis CW, et al. Pharmacology of INS3 721 7 [P(1 )-( uridine 5 0 )- P(4 )-( 2 0 -deoxycytidine 5 0 )tetraphosphate, tetrasodiu...

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... An open-label, phase I, single administration, dose-escalation study of ADGVPEDF. 11D (ADPEDF) in neo- vascular age-related macular degeneration (AMD). Hum Gene Ther 20 01; 12: 2 029 20 32. 77. Lai ... protein expres- sion from adeno-associated viral vectors in the eye. Mol Ther 20 02; 6 :23 8 24 2. 46. McGee LH, Rendahl KG, Quiroz D, et al. AAV-mediated delivery of a tet-inducible repor...

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... Probes as Sustained-Release Drug Delivery Systems . . . . 21 6 Microelectromechanical Systems Drug Delivery Devices . . . . 21 9 References . . . . 22 2 PART III: LOCAL DRUG DELIVERY APPROACH TO ... brain tumors (23 ,24 ). This is composed of a bio- erodible hydrophobic A–B block copolymer (poly-[bis-9-carboxyphenoxy propane ]- sebacic acid) containing the almost insoluble...

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... Ophthalmol 20 02; 86 :24 7 24 8. 32. Ip MS, Kumar KS. Intravitreous triamcinolone acetonide as treatment for macular edema from central retinal vein occlusion. Arch Ophthalmol 20 02; 120 : 121 7– 121 9. 33. ... 506 (1%) in 1,4-Dioxane. We used poly( Dl-lactide-co-glycolide), with a weight-averaged molecular weight of 63,000, whose copolymer ratio of DL-lactide to glycolide was 50:50 (22 )....

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... of patients No. with 4-week follow-up before any retreatment No. with 1 2- week follow-up before any retreatment 1 6 10 50, 75, 100, 150 30 a 22 22 19 b 2 6 10 50, 75, 100, 150 20 37 28 c 17 d 3 12 10 50, 75, ... Retina 20 00; 20 : 520 – 523 . 27 . Perkins SL, Gallemore RP, Yang C-H, Guo H, Ashton P, Jaffe GJ. Pharmacokinetics of the fluocinolone/ 5- uorouracil codrug in the g...

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... acetonide sustained drug delivery device to treat severe uveitis. Ophthalmology 20 00; 107 :20 24 20 33. 25 . Jaffe GJ, McCallum RM, Branchaud B, Skalak C, Butuner Z, Ashton P. Long-term follow-up results ... into either a high-risk or a low-risk group. Of the 130 patients in the low-risk group, 12 (9 .2% ) developed postoperative PVR. Of the 82 patients in the high-risk group, 23...

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... Ophthalmol Vis Sci 20 01; 42: 283 29 0. 24 . Jaffe GJ, Ben-Nun J, Guo H, et al. Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. Ophthalmology 20 00; 107 :20 24 20 33. 25 . Penfold ... J Ophthalmol 1998; 26 :27 7 28 1. 31. Danis RP, Ciulla TA, Pratt LM, Anliker W. Intravitreal triamcinolone acetonide in exu- dative age-related macular degeneration. Retin...

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... diffusion, 20 6 FK506, 45 Fluocinolone acetonide device nondegradable, 27 1 27 5 Fluorescein, 12 14, 104 Fluorescein angiography, 22 7, 23 4, 25 0, 29 9, 309 5-Fluorouracil (5-FU), 17, 28 3, 28 5 Fluoroquinolones, ... junctions, 27 Adriamycin, 176 Age-related macular degeneration (AMD), 29 , 71– 72, 77, 80, 144, 180, 23 1, 25 7 neovascular (wet), 24 9 non-neovascular (dry), 24...

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