Review Cells of the synovium in rheumatoid arthritis docx

... mechanism of degradation of the surface cartilage of the inflamed joint is not fully understood, a combination of the invasive properties of the synovial tissue and the expression of degrading enzymes ... suppressing bone resorption within days of administration [36,37]. Other molecular targets of osteoclasts are cathepsin-K, a matrix degrading enzyme, the matrix-b...

Ngày tải lên: 09/08/2014, 10:20

... The role of T cells in the SKG mutant model has been demonstrated by the predominant infiltration of a Vβ-restricted subset of CD4 + T cells in the inflamed synovium [20]. Adoptive transfer of splenic ... driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional s...

Ngày tải lên: 09/08/2014, 10:20

... chemokines, and form B cell aggregates in the target organ of rheumatoid arthritis. In this review we analyze the multi- faceted role that B cells play in the pathogenesis of rheumatoid arthritis ... and improvement in clinical disease activity, thereby enhancing our understanding of the role played by B cells in human disease. Competing interests The au...

Ngày tải lên: 09/08/2014, 10:20

... abundant in the synovial lining and sublining layers of the synovium associated with CCL20 (MIP-3α)-expressing cells, as well as in rheumatoid nodules and the synovial fluid. In synovial tissue the ... understanding of RA pathogenesis. In the near future, approaches developed to image DC in situ in patients, and to use DC therapeutically, will help to validate...

Ngày tải lên: 09/08/2014, 10:20

... assess the effects of the inflammatory joint disease on the local remodeling of joint structures. The role of the chondrocyte itself in cartilage destruction in the human rheumatoid joint has ... limited expression of β-catenin in joint tissues of patients with RA, but high expression of the inhibitor of Wnt/β-catenin signaling, DKK-1, in the inflamed...

Ngày tải lên: 09/08/2014, 10:21

... altered expression of integrin/selectin pairs on the surface of the two cell types (reviewed in [2]). Because the synovial cytokine milieu (including the Mφ-derived TNF-α) upregulates the expression of these ... dysregulation of the IL-18 system [61]. Interleukin-23 The genuine role of IL-23, a cytokine of the IL-12 family predominantly produced by Mφ or dendriti...

Ngày tải lên: 09/08/2014, 10:22

Ngày tải lên: 09/08/2014, 10:22

... inter- phalangeal joints of forefeet. The presence of a single erosion was sufficient to fulfil the requirement of an erosive disease. The presence of rheumatoid factor of any of the immunoglob- ulin isotypes ... TNF-α-converting enzyme [28]. Taking into consideration increased levels of TNF-α in patients with RA and the obvious effect of TNF-α neutralization for...

Ngày tải lên: 09/08/2014, 06:23

... 46:1470-1479. Available online http:/ /arthritis- research.com/content/5/5/R269 R275 2. Panayi GS, Lanchbury JS, Kingsley GH: The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid ... IL-4 increased the number of Th2 cells. Furthermore, IL-7 and IL-4 additively decreased the number of Th1 cells and additively increased the nu...

Ngày tải lên: 09/08/2014, 01:23

... Switzerland). In each experiment, we counted the number of positive cells in the adhesion and matrix metalloproteinase expression of RA- SF [22]. The expression of ECM proteins in proliferating RA-SF, therefore, ... is induced during growth inhibition in murine cell lines [33]. Recently, Taniguchi et al. [34] showed that cyclin-dependent kinase inhibitor p16 INK4a is ind...

Ngày tải lên: 09/08/2014, 06:22