immunomodulatory activities of japanese traditional medicines in rheumatoid arthritis

... presence of erosive disease While high-frequency (grey-scale) US measurements of joint space are robust, showing reproducible delineation of synovial thickening in small joints of the hands in patients ... K: The links between joint damage and disability in rheumatoid arthritis Rheumatology (Oxford) 2000, 39:122-132 van der Heijde DM: Plain X-rays in rheumatoid arthritis: overview of scoring methods, ... Pallwein L, Herold M, Helweg G, ZurNedden D: The value of contrast-enhanced color Doppler ultrasound in the detection of vascularisation of finger joints in patients with rheumatoid arthritis Arthritis...

Ngày tải lên: 09/08/2014, 01:23

... M: Cloning and expression of interleukin-18 binding protein FEBS Lett 1999, 445:338-342 Novick D, Kim SH, Fantuzzi G, Reznikov LL, Dinarello CA, Rubinstein M: Interleukin-18 binding protein: a ... without ng/ml of IL-12, ng/ml of IL-18, µg/ml of IL-18 binding protein (IL-18BP), or a combination of these (b) Cells were activated with 200 ng/ml of phytohemagglutinin (PHA) and ng/ml of phorbol ... Tanimoto T, Kurimoto M, Morita Y, Ohmoto Y, Makino H: Interferon-gammainducing activity of interleukin-18 in the joint with rheumatoid arthritis Arthritis Rheum 2001, 44:275-285 Aizawa Y, Akita...

Ngày tải lên: 09/08/2014, 01:23

... blue protein stain (CII) illustrating the separation of the CB peptides of bovine CII with a linear salt gradient (dotted line) (b) Coomassie blue staining of purified CB peptides of bovine CII ... Correlation of antibodies against bovine type II collagen (CII) and human CII Scatter plot of the levels of IgG antibodies against human CII and bovine CII in sera of patients with rheumatoid arthritis ... digestion of bovine CII and purification of CB10 and CB11 peptides CNBr digestion of bovine CII was performed with mg of purified bovine CII This was dissolved in ml of 70% (v/v) formic acid, containing...

Ngày tải lên: 09/08/2014, 01:23

... nucleotide 519, which results in a switch from arginine (R) to histidine (H) at amino acid position 131 in the immunoglobulin-binding domain [28] Genotyping was performed using a nested amplification ... Berg WB: Coordinate expression of activating Fcγ receptors I and III and inhibiting Fcγ receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated ... activating and inhibitory FcγRs influences the development of both immune complex-mediated and collagen-induced arthritis [9,10] Polymorphic variants that increase the expression or affinity of these...

Ngày tải lên: 09/08/2014, 07:20

... France), followed by staining with phycoerythrin (PE)-conjugated antiNFκB p50 (E-10; a mouse IgG1 monoclonal antibody against amino acids 120 to 239 mapping at the amino terminus of human NFκB p50; ... mRNA in the six bone marrow CD34+ cells (Figure 3) The results indicate that the elevation of NFκB1 mRNA leads to the increase in NFκB1 protein expression Relevance of expression of NFκB1 mRNA in ... C-reactive protein (CRP) levels in RA patients (Figure 5) The data thus indicate that the upregulation of NFκB1 mRNA in bone marrow CD34+ cells is independent of the activity of the systemic inflammation,...

Ngày tải lên: 09/08/2014, 07:20

... large variety of data organized in a systematic way After an initial period of restricted use of the data by the initial investigators, the access to clinical and genetic anonymous individual data ... laboratory typings The authors are indebted to patients and controls for their kind participation All of these contributions were invaluable for the setting up of the database used in this article Infrastructures ... on rheumatoid arthritis (RA) susceptibility in Caucasoids and nonCaucasoids Table Overall effect estimation of genotypes resulting from the classification of HLA-DRB1 alleles on rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 10:23

... ApoB Insulin resistance was evaluated from fasting glucose and insulin using the Homeostasis Model Assessment of Insulin Resistance (HOMA IR) [37] and the Quantitative Insulin Sensitivity Check Index ... the WHO definition This phenomenon may be explained by differences in the components and cut-off values used in the definitions The WHO is the only definition to include albumin/creatinine ratio ... demonstrating that the use of glucocorticoids is not associated with the presence of the MetS [44], thus again arguing against a potential anti-inflammatory mechanism of action of methotrexate In view...

Ngày tải lên: 09/08/2014, 14:22

... implicated in the pathogenesis inflammation in RA by the induction of the infiltration of leucocytes into local joint [32] Because of the pivotal role of ICAM-1 and VCAM-1 Page 12 of 15 in inflammation, ... activation of Page of 15 FLS in RA remained unsettled, particular at the local inflammatory joints In an attempt to further elucidate the immunopathological roles of IL-27 in the joint inflammation of ... molecules and chemokines indicates the distinct signaling pathways in inflammatory responses Such induction of chemokines by IL-27 in RA-FLS was not completely inhibited by those inhibitors, other...

Ngày tải lên: 12/08/2014, 14:22

... from Japanese raw rice Manufacturing of the Rice-fluid was conducted in five phases Phase involved the addition of to 20-times volume of distilled water to either of the two kinds of raw Japanese ... raw rice Discussion We investigated the in vitro antimicrobial activities of the three kinds of Rice-fluid against various species of microorganisms including H pylori strains by the timekill-curve ... kind of Rice-fluid was proved to be devoid of bactericidal activity against strains of E coli, S aureus, S epidermidis, E faecalis and P aeruginosa, and strains of K pneumoniae and strains of...

Ngày tải lên: 31/10/2012, 17:03

... for the detection of mucin-containing cells Because the inflammatory component of the mucosa was virtually identical to that found in human H pylori gastritis, the degree of inflammation could ... Histopathological findings In animals from non- H pylori inoculated groups (C and D), inflammatory cell infiltration into the lamina propria was negligible (Table and Fig 2C) In contrast, active ... 6.4±0.7 0.9±0.2 0.9±0.1 2A) In addition, no intestinal metaplasia or tumors in the gastric mucosa were observed in any groups based on the findings of this experiment In addition to serological...

Ngày tải lên: 08/08/2014, 16:23

... are involved in the joint degradation process in RA Thus, MCP-4 ⁄ CCL13 might have roles not only in the proliferation of synovial cells but also in the invasion of synovial cells, resulting in ... Results of a multicenter placebocontrolled double-blind randomized phase III clinical study of treatment of rheumatoid arthritis with recombinant interferon-gamma Rheumatol Int 8, 87–93 Sigidin YA, ... (2001) An investigation of cell proliferation and soluble mediators induced by interleukin 1beta in human synovial fibroblasts: comparative response in osteoarthritis and rheumatoid arthritis In amm...

Ngày tải lên: 16/03/2014, 05:20

... for inhibitor of apoptosis protein) domain is an evolutionarily conserved zinc-binding motif Many, but not all, proteins containing the BIR domain (BIR family proteins) play important roles in ... are distinct proteins rather than the nonallelic isoforms of a single protein in pseudotetraploid X laevis Another cDNA encodes a 401-residue protein containing two N-terminal BIR domains and ... survivin2, encodes a similar but distinct molecule of 157 aminoacid residues containing a single BIR domain As a very similar protein, named SIX, was recently identified as an RXRa-interacting protein...

Ngày tải lên: 30/03/2014, 16:20

... encoding systems, and the pronunciation(s) of the character in Chinese (listed under the feature kMandarin in the Unihan database), in Japanese (both the On reading and the Kun reading : kJapaneseKun ... pronunciations in Japanese, Chinese, and Korean:   U+91D1 U+91D1 U+91D1 U+91D1 kJapaneseKun KANE kJapaneseOn KIN KON kKorean KIM KUM kMandarin JIN1 JIN4   In the example above, is represented in its ... value in the first column, with a feature name in the second column and the values of the feature in the third column The Japanese Kun reading of is KANE, while the Japanese On readings of is KIN...

Ngày tải lên: 31/03/2014, 03:20

... evaluate the severity of psoriatic lesions by assessing the extent of skin involvement, erythema, plaque thickness, and degree of scaling [31] The PASI score can vary in increments of 0.1 units from ... agents) with the goal of preventing or slowing permanent structural joint damage and longterm disability in IRD is the accurate monitoring of HRQL in daily practice and in clinical trials [37] The ... planning of the healthcare services should take these findings into account by maintaining the focus on impairment and physical function, but also focusing on the mental and social consequences of...

Ngày tải lên: 18/06/2014, 19:20

... directly obtained patient preferences in a sample of rheumatoid arthritis patients Methods Study sample A sample of patients with a rheumatologist-confirmed diagnosis of rheumatoid arthritis (RA) ... have found that, for the majority of individuals, incorporating the relative importance of domains in indirect HRQL measurement has little effect on the accuracy of utility estimation [43] While ... issues in obtaining values for health states Med Care 1984, 22:543-552 Jenkinson C, Gray A, Doll H, Lawrence K, Keoghane S, Layte R: Evaluation of index and profile measures of health status in a...

Ngày tải lên: 20/06/2014, 15:20

... preparation of recombinant vaccines For identification of recombinant protein, Sf-9 cells were infected with recombinant baculoviruses in 96-well microplate and incubated for days Infected cells ... cultured in liter spin flask, and suspended in 15 ml of PBS Immune response of mice given recombinant prME, E and NS1 proteins To evaluate the immunogenicity of recombinant proteins, groups of 13 ... play a dominant role in the receptor binding, generation of neutralizing antibodies and induction of a protective immunity [11,20] In addition to the structural proteins, NS1 protein is also...

Ngày tải lên: 07/08/2014, 18:21

... eniws dna staog rof metsys gnirotinom-ores A aeroK ni VEJ tsniaga detaniccav ton yltnerruc era yeht esuaceb slamina citsemod ni noitcefni VEJ fo gnirotinom lacigolores rof lamina lenitnes doog ... tnarg a yb yllaicnanif detroppus saw krow sihT doolb fo gnilpmas rof eeL naS-gnuhC rD dna tpircsunam eht fo gnidaer luferac rof kraP gnoY-eeJ rD knaht ot ekil dluow srohtua ehT stnemgdelwonkcA ... )021/62( %7.12 saw VEJ rof etar evitisop eht dna ytic ujgnoyK ni ylno detcelloc erew selpmas mures enivo eht tub ,aeroK ni 6591 ni tuo deirrac saw ,staog dna peehs gnidulcni ,slamina citsemod ni noitcefni...

Ngày tải lên: 07/08/2014, 20:23

... regulation by interleukin 12 of the development of murine type II collagen-induced arthritis: possible involvement of endogenous interleukin 10 and tumor necrosis factor alpha Arthritis Rheum ... FLSs, indicating that the major cellular sources of IP-10 are probably either monocytes or PMNs during coculture Involvement of integrin–ICAM-1 ligand interactions in the upregulation of IP-10 ... molecules, including the ICAM-1–integrin pathway [19,29] The potential role of these molecules in FLS–leukocyte interactions was investigated by assessing the capacity of specific antibodies to inhibit...

Ngày tải lên: 09/08/2014, 01:21

... Mohan S, Ljunghall S: Circulating levels of insulin-like growth factor-I and -II, and IGF- binding protein-3 in inflammation and after parathyroid hormone infusion Bone Miner 1994, 24:25-31 33 De ... included in a 2-year, randomized, single-blind, controlled study The included patients had an active disease that met at least two of the following criteria: ≥6 painful joints, ≥3 swollen joints, ... of sIL-6R The alteration in sIL-6R was inversely associated with change in BMD in the lumbar spine To find out if there was an independent correlation between sIL-6R and BMD in the lumbar spine,...

Ngày tải lên: 09/08/2014, 01:21

... SOCS box protein (ASB4), thought to mediate ubiquitination of various target proteins, and the intracellular domain of the Notch receptor (involved in the maintenance of cells in an undifferentiated ... synovial lining and stromal cells [75] In adjuvant-induced arthritis, HIF-1α has been localized to synovium of inflamed joints [12] Conversely, targeted deletion of HIF-1α in cells of the myeloid lineage ... hypoxia in the joint cavities of rheumatoid arthritis and osteoarthritis patients Clin Rheumatol 2007, 26:2023-2029 Jawed S, Gaffney K, Blake DR: Intra-articular pressure profile of the knee joint in...

Ngày tải lên: 09/08/2014, 01:22