Báo cáo y học: " Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections" pdf

... article Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue ... metalloproteinase (MMP) mRNAs in human synovial fibroblasts (SFs) by Staphylococcus aureusInduction of multiple matrix metall...

Ngày tải lên: 09/08/2014, 08:23

... [14]. In vertebrates the (2–5)A pathway is also induced by interferons [15]. The major enzyme in this pathway, the (2–5)A synthetase catalyzes the synthesis of a series of 2¢)5¢- linked oligoadenylates, ... to 24 h . The i dentity of the p 3 A 2 product synthesized by the (2–5)A synthetase both in tissue and in primmorphs of S. domuncula was verified by...

Ngày tải lên: 21/02/2014, 15:20

... on the availability of these acc essory factors. When transfected in HeLa cells, the activity of the COUP-TFI promoter was a bout the same r egardless of the size of the s equence used until the ... likely due to poor DNA-binding af®nity of full-length Ets-1 rather than to poor potential of its activation domain. This is supported by the existence (at least in...

Ngày tải lên: 17/03/2014, 17:20

... is calculated by dividing the counts/min in the presence of CII by the counts/min in the presence of ovalbumin. Analyses of cytokine production by ELISA Mononuclear cells were isolated from the Peyer’s ... oedema and erythema from the ankle to the tarsal bone; and 4 = oedema and erythema from the ankle to the entire leg. The sum of values from three...

Ngày tải lên: 09/08/2014, 01:23

... differently depending on the kind of antigen-presenting cell. Another issue to address is the role played by synovial tissue in diar- throdial joints because these joints are predominantly affected. The ... paraffin sections were stained with haematox- ylin and erythrosine [26]. Statistical analysis Frequency of arthritis was analyzed using the χ 2 test, and anti- b...

Ngày tải lên: 09/08/2014, 07:20

... throughout the tissue, including the lining layer and lymphocyte infiltrates. Colocalisation analysis revealed that the CD68 + synovial lining layer contained a large number of cells stained intensely ... potent inhibitor for the synthesis of proin- flammatory cytokines in monocytes/macrophages and T cells [11], is substantially expressed by lining macrophages and inf...

Ngày tải lên: 09/08/2014, 08:22

... mediators of arthritis. Increased levels of these cytokines are found in the joints of rheumatoid arthritis patients, and the cytokines trigger arthritis when applied into the joints of naïve mice. ... strains. In the case of C57Bl/6 mice, only 40% develop arthritis – and the severity of inflammation in the joints also proved to be significantly lower...

Ngày tải lên: 09/08/2014, 10:23

... types, as a result of which Figure 3 Induction of HLA-B27 heavy-chain dimers in KG-1 cells and human dendritic cellsInduction of HLA-B27 heavy-chain dimers in KG-1 cells and human dendritic cells. ... accumulation of misfolded heavy chains and correlates with the magnitude of the unfolded protein response in transgenic rats: implications for the pathogenes...

Ngày tải lên: 09/08/2014, 13:21

... to increase its DNA binding activity [27], it will be interesting to test whether the ERK activity could be induced by NBS1 overexpression, leading to the phosphorylation of HSF4b. HSPA4 and ... previously demonstrated that c-MYC, a dominant oncoprotein, directly activates NBS1 expression [7]. The proliferation-inducing function of NBS1 is supported by the phenotypes of di...

Ngày tải lên: 10/08/2014, 05:21

... antibody developed by D.A. Fischman was obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD and maintained by the University of Iowa, Department of Biological ... stages includes heart looping, chamber formation, and ballooning. Our study demonstrated that the expression of myosin, stained by the anti-cardiac myosin an...

Ngày tải lên: 10/08/2014, 10:20