Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" ppsx

... presence of inflammatory lesions in the vicinity of apoptotic cells, as observed both in UVB-induced and in LE skin lesions in SLE patients, suggests that these lesions result from an inflammatory clearance ... cells at any Figure 3 Co-localisation of apoptotic keratinocytes and infiltrate in lupus erythematosus (LE) skin lesionsCo-localisation of...

Ngày tải lên: 09/08/2014, 08:22

... apoptosis of synoviocytes, intra-articular gene transfer could decrease the hyperplasia of the synovial intimal lining. Although not feasible for systemic administration, local therapy could debulk ... especially interesting target because it rapidly induces apoptosis in cultured synoviocytes [5]. PUMA is a Bcl-2 homology 3 (BH3)-only pro -apoptotic Bcl-2 family member recently ide...

Ngày tải lên: 09/08/2014, 08:22

... Section of Respirology, Department of Internal Medicine; Richard Warrington: Section of Allergy and Immunology, Department of Internal Medicine; and Mary Cheang: Department of Community Health ... control of cytokine production. 38 The hormone leptin of the IL-6 family has effects on inflammation, including the release of IL-6 from macro- phages and lymphocytes. 39,40 Leptin l...

Ngày tải lên: 08/08/2014, 21:20

... spinally recuperate. Although unknowns regarding spinal nycthemeral varia- tions in quadrupeds remain, further investigations may help define the physical aspects of recuperation during sleep in ... there are two combined forces working against the task of maintaining hydraulic vertebral spacing: 1) stabilizing musculature and 2) grav- ity. In absolute terms, an anti-gravity muscle...

Ngày tải lên: 10/08/2014, 09:20

... the site of injection Injection of microorganisms resulted in a dramatic decrease in numbers of both circulating and tissue in ltrating haemocytes within 3 h of injection. To study haemocyte behaviour ... were fixed for 10 min by addition of 1 vol. ice-cold 4% paraformal- dehyde in 100 m M NaCl/P i containing 10% saccharose. Cells were centrifuged on slides for 5 min at 20...

Ngày tải lên: 18/03/2014, 01:20

... management including diagnosis, family studies, prognostic information, prenatal diagnosis and is useful in defining new diseases. In this review we outline the clinical utility of molecular testing for ... vaccine responses can be undertaken [5,6]. Further advanced tests including the enumeration of subsets of lymphocytes using flow cytometry can be useful in evaluating patien...

Ngày tải lên: 08/08/2014, 21:20

... cost-effectiveness of cyclooxygenase 2-selective versus nonselective nonsteroidal anti-inflamma- tory drugs in a cohort of coumarin users: a pharmacoeco- nomic analysis linked to a case-control study. Clin Ther ... Chiou CF, Ofman J: Minimizing complications from nonsteroidal antiinflammatory drugs: cost-effectiveness of competing strategies in varying risk groups. Arthritis Rheum 2...

Ngày tải lên: 09/08/2014, 01:22

... these hypotheses in autoimmune individuals and in rodent auto- immunity models because intrinsic B cell hyperreactivity, the provision of excessive T cell help and the presence of inflammatory mediators ... should have indirect effects on other cell types and on inflammatory mediators, some of which might improve disease activity independently of effects on autoantibody produc...

Ngày tải lên: 09/08/2014, 01:24

... corresponding to the microscopic findings in hematoxylin and eosin staining. In addition, leukocyte infiltration into the synovial fluid of the inflamed knee joints following rTRAIL treatment was reduced ... estimate the degree of TUNEL staining in synovial tissue sections. Investigators blindly reviewed primarily two areas: synovial lining and subsynovial regions. The extent of...

Ngày tải lên: 09/08/2014, 07:20

... subsequently accumulated in the mineralised matrix. Increased OPN may augment OB synthetic activity by increasing OB longevity and surface extent of bone formation. Hence, increased OPN mRNA expression in OA may contribute ... not for citation purposes) lular matrix, is synthesised only by bone-forming OB cells. OCN is suggested to be involved in the mineralisation process of newl...

Ngày tải lên: 09/08/2014, 08:23