Báo cáo y học: "Phenotypic and functional characterisation of CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis" pps

... arthritis (JIA) and to investigate the functional and anatomical heterogeneity of these cell subsets in relation to the expression of the inflammatory chemokine receptors CXCR3 and CCR5. Memory ... provided the original work is properly cited. Abstract The aim of the study was to characterise CCR7 + and CCR7 - memory T cells infiltrating the infla...

Ngày tải lên: 09/08/2014, 06:22

... be investigated because of the paucity of the latter cells in SF. In adulthood, transitional B cells generated in the bone marrow are released into the bloodstream and transported to the spleen, ... expression of costim- ulatory molecules. Upregulation of CD86 on synovial memory B cells suggests that these cells can efficiently present anti- gen to and...

Ngày tải lên: 09/08/2014, 14:22

... over the prominence of the muscles at the base of the most ulna r digit (hypothenar muscles) to check for the presence of action potentials in the muscles. The motor nerve conductio n velocity (MNCV) was ... chain reaction (PCR) was used to identify the sex- determining region of the Y- chromosome (Sry) and b-actin to investigate whether cells of donor...

Ngày tải lên: 10/08/2014, 10:20

... black staining was used to confirm protein presence and to detect bands not stained by the ruthenium red dye. Analysis of antifreeze activity Antifreeze activity was quantitated a s thermal hysteresis, which ... have enhanced binding to ice and this is not likely to be the case. This may be relevant to the calculation of smelt AFP activity. The activity of smelt AFP...

Ngày tải lên: 24/03/2014, 03:21

... proliferation of γδ T cells. Some infor- mation has been obtained on the capacity of γδ T cells to produce cytokines. To fully delineate the regulatory and effector activities of γδ T cells in ruminants, ... maintained by cycles of antigen stimulation and culture in the presence of CM . Whether this reflects a greater capacity to proliferate in...

Ngày tải lên: 07/08/2014, 14:22

... the TIMP-2 inhibitory effect, thereby supporting MMP9 activity in vitro. In the present study, we show that RA patients frequently develop autoimmune response to TIMPs that may act as a functionally ... examples of protective rather then harm- ful autoimmunity in RA. This hypothesis seems to conflict with the present view of MMP-mediated proteolytic degradation of cartil...

Ngày tải lên: 09/08/2014, 06:23

... [12]. These obser- vations, together with knowledge of the hierarchy of regulatory networks, have led to the hypothesis of ‘analog’ and ‘digital’ components of gene regulation in bacteria. The ... with lengths ranging from 1 to 14 kbp (Figure 1). They then determined the transcrip- tional profiles of the EPODs by DNA microarray analysis and found that they fell...

Ngày tải lên: 09/08/2014, 20:21

... formation [16,17]. It preferentially undergoes proteolysis to yield NT- and CT-truncated that interact with cytoske letal components to form NFT-like inclusions in neuronal cells [16]. To understand the pathogenesis ... facilitating the transportation of plasma chylomicron remnant to the liver through either the remnant receptor or LDLR [8,9]. Owing to distinct domai...

Ngày tải lên: 10/08/2014, 05:21

... observed in all of the stem-loop structures. We further show that RRE sequences derived from one of the samples (VT5) retained the ability to bind to Rev protein under in vitro conditions, though the ... for this conservation is not known, it is tempting to speculate that certain mutations are uniquely selected in our region. Host factors, besides other factors may pot...

Ngày tải lên: 10/08/2014, 05:21

... likely were attributable to the treatment started on the index date, rather than to natural variations in disease activity; switching to a different RA medication after the index date; or other ... not adhere to the study protocol, including continuing to take the medication, are generally excluded from continuing to participate in the trial. These patients’ out...

Ngày tải lên: 25/10/2012, 10:45