ccr7 and ccr7 cd4 memory t cells isolated from sf

... after total knee/hip arthroplasty Patients were informed about the purpose of the study and gave written consent Approval for the study was granted by our ethics committee Patient characteristics ... but they were not impaired in synovial fluid from RA patients Our data indicate that NKT cells may be involved in the disease process of RA and that a strategy to boost the regulatory potential ... aberrant presentation of the natural NKT cell antigen, but not decreased reactivity, might account for the NKT cell reduction in these responder patients In contrast, in 46.2% of the patients ('nonresponders')...

Ngày tải lên: 09/08/2014, 06:22

... Kaplan-Meier method Results Patient characteristics Patient characteristics are shown in Table for the 22 patients treated with IFN-a 2b, the 22 patients not treated with IFN-a 2b, and the 20 healthy subjects ... donors and by stage in the 44 patients with melanoma (22 patients treated in this study and the other 22 patients who were referred to our institution during the study); these data again suggest that ... with IFN-a 2b treatment may indeed contribute to the antitumor response A better understanding of the mechanism of action of IFN-a 2b may facilitate the development of treatment strategies to...

Ngày tải lên: 18/06/2014, 16:20

... compartment in the periphery [10] The association of CD4+ CD28– T cells with disease status has given rise to the hypothesis that these cells directly contribute to disease manifestations Patients ... cytokines in the absence of a costimulatory pathway CD4+ CD28– T cells contribute to the cell infiltrate and exhibit increased survival after apoptotic stimuli Resistance to apoptosis in CD28– T cells ... online http://arthritis-research.com/content/5/4/R210 In the present study we evaluated the correlation between the CD4+ CD28– T- cell subset and extra-articular manifestations, magnitude of joint involvement,...

Ngày tải lên: 09/08/2014, 01:22

... of MTX or anti-TNF treatment Forty patients (21 SpA and 19 RA) received anti-TNF drugs All RA patients and 10/21 SpA patients had anti-TNF + MTX Twenty-two MTX naive RA patients received MTX EBV ... AU and IG contributed to the ELISPOT assay analyses GC and AV contributed to interpretation of the data Competing interests The authors declare that they have no competing interests Page of (page ... both patients, an EBV-specific T- cell response to latent peptides was detectable at baseline but was not detectable at week 12 Nevertheless, the response to lytic peptides was persistent in both...

Ngày tải lên: 09/08/2014, 14:21

... cultures after stimulation with TLR ligands Secretion of proinflammatory cytokines in cultures from septic patients was significantly diminished at both time points compared with cultures from ... and participated together with H-DV in the interpretation of all data and revised the manuscript for important intellectual content Acknowledgements The present work is dedicated to Holger Poehlmann ... cytokine-positive monocytes after LPS stimulation were less pronounced between patients and controls Notably, the percentage of IL-1β-positive monocytes did not differ between septic patients and controls...

Ngày tải lên: 13/08/2014, 18:22

... subjects and characterized TCCs specific for this antigen The data obtained suggest that hnRNP-A2 may constitute an important T cell autoantigen in patients with SLE, indicating a potential role ... CD4+ CD28+ and CD4+ CD28-) secreted comparable amounts of IFNγ and IL-10 (Figure 3b) CD4+ T cells (obtained from two SLE patients and two healthy controls) were stimulated with anti-CD3 and antiCD28 ... incubation with supernatants from T cell clones (TCCs) CD4+ T cells of two healthy controls (HC-1, (TCCs) HC-2) and two systemic lupus erythematosus (SLE) patients (SLE-1, SLE-2) were stimulated...

Ngày tải lên: 09/08/2014, 08:22

... manuscript preparation UW participated in patient recruitment, statistical analysis, and manuscript preparation HH participated in the coordination of the study and helped with patient recruitment and ... death on cytokine production of stimulated T cells upon coincubation with catecholamines was tested After stimulation of T cells for 48 hours with anti-CD3-mAb and anti-CD28-mAb together with ... HDs and patients with RA (data not shown) Discussion In the present study, we determined the effects of catecholamines on cytokine production of T cells from patients with RA and HDs In addition,...

Ngày tải lên: 09/08/2014, 08:22

... at each visit to the clinic, the patients were questioned about compliance with the study diet Also, between visits, the nurse made phone calls to the patients and the patients had the opportunity ... coinventor on some patents relating to anti-PC The other authors declare that they have no competing interests Available online http://arthritis-research.com/content/10/2/R34 Authors' contributions ... correlated to changes of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) [13] These results suggest that the abnormal lipid levels are related to inflammation On the other hand, treatment...

Ngày tải lên: 09/08/2014, 10:23

... related to the fact that most patients had low inflammatory activity However, when separating the patients into those with low DAS28 and those with DAS28 corresponding to moderate activity it was ... the patients with rheumatoid cachexia In the present cohort of patients we did not find that DAS28 or CRP differed between those with cachexia and the rest of the patients, probably related to ... not find that the FA intake differed between cachectic and non-cachectic patients Adherence to a Mediterranean diet did not differ either between cachectic and non-cachectic patients Thus, diet...

Ngày tải lên: 09/08/2014, 13:22

... Competing interests The authors declare that they have no competing interests Authors' contributions TET participated in the conception and design of the project and in the analysis and interpretation ... interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and interpretation of data KMJD contributed to the acquisition ... data HRG contributed to the revision of the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript...

Ngày tải lên: 09/08/2014, 01:22

... Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts Arthritis Rheum 2004, 50:776-784 Arnett FC, Edworthy ... response studies and participated in the immunoassays MLC participated in the design of the study and performed the statistical analysis MKP participated in the isolation of the cells CHY drafted the ... intense than that in RA PBMC (Fig 7b) To confirm the link between PI3K activity and NF-κB, we performed EMSA to determine the NF-κB binding activity after treatment with both LY294002 and PDTC...

Ngày tải lên: 09/08/2014, 06:22

... anti-TNF-α therapy for treatment of persistent active disease, despite treatment with methotrexate Patients were enrolled, starting from when infliximab entered the market, from January 2001 to ... juxta-articular bone destruction Competing interests The authors declare that they have no competing interests Authors' contributions The initial draft of the report was written by HM and PM Patients ... now on the market, and it would be unethical not to use and even to withhold infliximab treatment from RA patients with active disease We regarded the optimal situation to be one in which the only...

Ngày tải lên: 09/08/2014, 10:20

... the new exercises, we presented to the experts the entire hand or foot that included the joint-of-interest from the single joint exercise This allowed us to test whether the presentation of the ... Martin Mola E, Pavelka K, Sany J, Settas J, et al.: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: ... Fatenejad S: Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate Results from the TEMPO trial Arthritis Rheum 2006, 54:3119-3125 Landewé R, van der...

Ngày tải lên: 09/08/2014, 10:20

... blocker rather than anakinra as a first biologic agent to treat RA patients, concordant with a recent consensus statement, and national and international registries [3] Treatment with recombinant IL-1Ra ... criteria within weeks Similar to experience with other biologics for the treatment of RA patients, there was a subset of patients who did not respond to treatment On the other hand, some patients ... related to study medication All patients with infectious events were treated with antibiotics and recovered fully within the expected time frame None of the patients prematurely discontinued treatment...

Ngày tải lên: 09/08/2014, 10:23

... Competing interests The authors declare that they have no competing interests Authors' contributions TET participated in the conception and design of the project and in the analysis and interpretation ... interpretation of data and contributed substantially to the drafting of the manuscript VFP participated in the acquisition, analysis, and interpretation of data KMJD contributed to the acquisition ... data HRG contributed to the revision of the draft of the manuscript GDK contributed substantially to the conception and design of the project and to the revision of the draft of the manuscript...

Ngày tải lên: 09/08/2014, 13:22

... years followup Of the 163 patients in this study, 128 had X-rays at all four time points, 29 at three time points and six patients at two time points The patients with and without hand X-rays had ... RA patients treated with penicillamine [24] Kalla and colleagues have also shown that DMARD treatment increase the cortical bone mass in RA patients [25] The DMARD-treated patients in this study ... statistical analyses and prepared the manuscript MH contributed in the statistical analyses and substantially contributed to the manuscript SØ organised the clinical data collection GH organised the...

Ngày tải lên: 09/08/2014, 14:22

... bursitis, synovitis and erosion) Sensitivity and specificity of the podiatrist's results were calculated from cross-tabulation against the radiologist's results as the gold standard Results Thirty ... Thirty two patients with RA were recruited One patient withdrew due to time issues during the visit Thirty one patients completed the study There were 24 female and male patients, 12 seronegative and ... helped to draft the manuscript SS participated in study design and coordination JB participated in the design of the study and helped to draft the manuscript CE participated in the design of the study,...

Ngày tải lên: 10/08/2014, 21:23

... editing the manuscript JTG performed statistical analyses and edited the manuscript GC participated in data collection and edited the manuscript NL performed statistical analysis and edited the ... (eight patients), asthma (eight patients) or rheumatoid lung disease (two patients) Demographic characteristics did not differ among those with and without PFT abnormalities; however, the proportion ... Competing interests The authors declare that they have no competing interests Authors' contributions DAP participated in the study design, data collection and analysis as well as in writing and...

Ngày tải lên: 12/08/2014, 14:21

... consecutive rheumatoid arthritis (RA) patients were recruited from the rheumatology outpatient clinics of the Dudley Group of Hospitals NHS Trust, UK All patients met the retrospective application ... Putte LB, van Riel PL: Modified disease activity scores that include twenty-eightjoint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis ... the second study is that manual methods were used to detect and mark out the vessel diameter during flow-mediated dilation (FMD) This method is less accurate than automated wall tracking software,...

Ngày tải lên: 12/08/2014, 17:21

... admitted) stayed as inpatients at the hospital after they were admitted The length of hospitalisation for these 32 patients was: a) between one to five days for eight patients (25% of the 32 patients), ... impact on the quality of life of the patient It also associates with very high costs to the health system Hence, it is important to identify strategies that may improve overall management and ... activities Data for numbers and reasons for hospital admissions as well as the length of hospitalisation (that is, total days that a patient stayed as an inpatient at the hospital as a result of the admission)...

Ngày tải lên: 12/08/2014, 17:22