Báo cáo khoa học: "In vitro and in vivo gene therapy with CMV vector-mediated presumed dog b-nerve growth factor in pyridoxine-induced neuropathy dogs" pot

Báo cáo khoa học: "Molecular characterization and genogrouping of VP1 of aquatic birnavirus GC1 isolated from rockfish Sebastes schlegeli in Korea" potx

... motif in GTP-binding proteins [1,16] and is observed in several viral proteins that have a tentative role in RNA replication [15]. The same motif was present in the IPNV strains [4] and in GC1 ... 25]. They identified several conserved domains associated with RdRps and GTP-binding proteinsin the IPNV strains; these domains were the same as those in other RNA viruses. However, they also ... Daltons, and it contains a single large ORF encoding the 846-amino acid VP1 protein. The VP1 sequence starts with the nucleotide sequence ‘GGAAA’ and contains the inverted terminal repeats ‘GGGTCAA-...

Báo cáo khoa học: The tetralogy of Fallot-associated G274D mutation impairs folding of the second epidermal growth factor repeat in Jagged-1 potx

... domain is nec-essary and sufﬁcient for binding to Notch receptors, with EGF1 and 2 substantially increasing the binding[38]. Although the structural determinants of the Not-ch ⁄ ligands interactions ... bonds half-cystines, and w7 the C-terminal linker residues), counting the muta-tions occurring in each window, and dividing these valuesby the average number of residues in the window.AcknowledgementsWe ... Winship PR& Handford PA (1998) A Gly –> Ser change causesdefective folding in vitro of calcium-binding epidermal growth factor- like domains from factor IX and ﬁbrillin-1. J Biol Chem...

Tài liệu Báo cáo khoa học: "Learning Parse and Translation Decisions From Examples With Rich Context" pdf

... R. Quinlan. 1986. Induction of decision trees. In Machine Learning I (I), pages 81-106. R. L. Rivest. 1987. Learning Decision Lists. In Machine Learning 2, pages 229-246. R. F. Simmons and ... context, integrating morphological, syntactic, semantic and other aspects relevant to making good parse decisions, thereby also allowing the parsing to be deterministic. Applying machine learning ... text parsing. Using • a rich and unified context with 205 features, • a complex parse action language that allows in- tegrated part of speech tagging and syntactic and semantic processing, •...

Báo cáo khoa học: " Concurrent capecitabine and upper abdominal radiation therapy is well tolerated" ppsx

... T, Sutter T, Zuhlke H, Hinke A, Kolling-Schlebusch K,Frings S: Phase I trial evaluating the concurrent combinationof radiotherapy and capecitabine in rectal cancer. J Clin Oncol2002, 20(19):3983-3991.7. ... Vaitkevicius VK, Du W,Levin KJ, Shields AF: A single-institution experience with con-current capecitabine and radiation therapy in gastrointesti-nal malignancies. Int J Radiat Oncol Biol Phys ... patients included 28 (32%) with pancreaticadenocarcinoma, 18 (20%) with cholangiocarcinoma, 11 (13%) with ampullary carcinoma, 11 (13%) with other primary tumors, 14 (16%) with liver metastases, and...

Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt

... POZ domain to interact with the cullins CUL3A and CUL3B [3,4,16], we inves-tigated what kind of protein–protein interactions werefacilitated by their MATH domains by performing twolMINT-7262855: ... [8,9]. BTB ⁄ POZ proteins areoften transcriptional regulators containing a C2H2domain for DNA binding, but can also be found in combination with various other protein–protein inter-action motifs, ... on the basis of homology with the C-terminalregion of meprins A and B and the TRAF-C domain, and, like the BTB domain, facilitates protein–proteininteraction [24]. Meprins are tissue-speciﬁc...

Tài liệu Báo cáo khoa học: Template requirements and binding of hepatitis C virus NS5B polymerase during in vitro RNA synthesis from the 3¢-end of virus minus-strand RNA docx

... radioactivity incorporated into the nucleic acids was measuredafter TCA precipitation and plotted against the incubation time in minutes.T. Astier-Gin et al. Binding and replication of 3¢-end of HCV minus ... requirements and binding of hepatitis C virusNS5B polymerase during in vitro RNA synthesis from the3¢-end of virus minus-strand RNAThe´re`se Astier-Gin, Pantxika Bellecave, Simon Litvak and Michel ... several domains of the 341 nucleotide region of the minus-strand3¢-end interact with HCV RdRp during in vitro RNA synthesis, in parti-cular the region located between nucleotides 219 and 239.AbbreviationsHCV,...

Báo cáo khoa học: "In vitro and in vivo gene therapy with CMV vector-mediated presumed dog b-nerve growth factor in pyridoxine-induced neuropathy dogs" pot

... hyyoun@snu.ac.kr In vitro and in vivo gene therapy with CMV vector-mediated presumed dog β-nerve growth factor in pyridoxine-induced neuropathy dogs Jin-Young Chung1, Jung-Hoon Choi2, Il-Seob Shin1, ... JC, Mata M, Fink DJ. In vivo gene therapy for pyridox-ine-induced neuropathy by herpes simplex virus-mediated Presumed dog β-NGF gene therapy in vitro and in vivo 369 (Gene therapy systems, ... pdβ-NGF in vitro and gene therapy using recombinant pdβ-NGF plasmid in the dog model, having pyridoxine-induced peripheral neuropathy. Materials and MethodsCloning of the presumed dog β-NGF...

Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

... heterologous expression of genes encoding metallo-proteins can lead to incorrect metal ion incorporation.This is observed in rubredoxin and desulforedoxinswhere zinc, instead of native metal ... and enrich the native R2F within its original genetic back-ground. A ﬁrst obstacle was the low rate of gene trans-fer into C. ammoniagenes [15,16], which is not a modelorganism, notwithstanding ... operate correctly,any introduced gene (cis-acting DNA) must comply with unknown (trans-acting factors) (e.g. chaperones orcofactors) in the host cell [14]. An increasing awarenessof these...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... interactions, aSTAT protein DNA-binding domain and an SH2domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a targetprotein [38,39]. Within zebraﬁsh stat6, ... regions containing the t-bet and foxp3 genes. Around t-bet, the genes TBK1-bind-ing protein 1, oxysterol-binding protein-like 7 (OS-BPL7) and mitochondrial ribosomal protein L10 werefound in the ... isshared by all FOX proteins, a leucine zipper domain and a C2H2 zinc ﬁnger domain, both of which arethought to help mediate DNA binding and may beinvolved in the induction of dimerization...

Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx

... triglyceride, glucose, leptin and insulin, and insulin sensitivity, in TG miceAfter 6 weeks of normal or HF diet, serum levels oftriglyceride, glucose, leptin and insulin were deter-mined (Fig. 4A). ... tail vein(t = 0 min) and immediately measured for glucose, usingan Antsense II. Porcine insulin was injected subcutaneously, and blood was collected at 30, 60, 90 and 120 min afterinjection.Measurement ... washing,the sections were incubated with the biotinylated goat anti-(rabbit IgG) for 30 min (Vector Laboratories, Burlingame,CA, USA), and this was followed by staining with theavidin–biotin–peroxidase...

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