Chapter 101 Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) doc

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 6) Peripheral blood smear from patients with membrane-cytoskeleton abnormalities. A. Hereditary spherocytosis. ... Hereditary elliptocytosis, heterozygote. C. Elliptocytosis, with both alleles of the α-spectrin gene mutated. [From L Luzzatto, in J Gribben and D Pravan (eds): Molecular...

Ngày tải lên: 07/07/2014, 04:20

... often associated with hemosiderinuria and an Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 2) Table 101- 2 General Features of Hemolytic Disorders General examination ... pyknosis and actual loss of the nucleus. Reticulocytes Increased Bilirubin Increased (mostly unconjugated) LDH Increased (up to 10X normal with...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 7) Clinical Presentation and Diagnosis The spectrum of clinical severity ... prophylaxis postsplenectomy is controversial. 4. HS patients often may require cholecystectomy. It used to be considered mandatory to combine this procedure with splenectomy, but this may not ... HE causing...

Ngày tải lên: 07/07/2014, 04:20

... dish of fava beans; but t rigger can be Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 11) Table 101- 5 Drugs that Carry Risk of Clinical Hemolysis in Persons with ... history taking Favism Acute Destruc tion of older fraction of G6PD- deficient red G6PD assay Triggere d by ingestion of large dish of fava beans; but t rigge...

Ngày tải lên: 07/07/2014, 04:20

... screening tests, which are suitable for population Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 12) Figure 101- 6 hemodialysis may be necessary, but if there ... of NNJ due to other causes. In cases with CNSHA, if the anemia is not severe, regular folic acid supplements and regular hematologic surveillance will suffice. It...

Ngày tải lên: 07/07/2014, 04:20

... Extracorpuscular Factors Hereditary Hemoglobinopathies Familial hemolytic uremic syndrome (HUS) Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 1) Harrison's ... of anemia in these two groups of patients are quite different, and they will be considered separately. Hemolytic Anemias Anemias due to increased destr...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 3) Figure 101- 1 cause considerable iron loss, needing replacement. With chronic ... needs frequent blood transfusions. Chronic iron overload will cause secondary hemochromatosis; this will cause damage, particularly to the liver, eventually leading to cirrhosis, and to the heart...

Ngày tải lên: 07/07/2014, 04:20

... instead autosomal recessive (with the patient being homozygous). Figure 101- 3 Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 5) Hemolytic Anemias Due to Abnormalities ... (including ankyrin and the so-called band 4.1 and band 4.2), which thus connect these two structures intimately. Figure 101- 2 Diagram of red ce...

Ngày tải lên: 07/07/2014, 04:20

... Chapter 101. Hemolytic Anemias and Anemia Due to Acute Blood Loss (Part 8) Abnormalities of the Glycolytic Pathway (Fig. 101- 1) Since red cells, in the course ... the jaundice persists and is usually associated with a very high reticulocytosis. The anemia is of variable severity; sometimes it is so severe as to require regular blood transfusions; somet...

Ngày tải lên: 07/07/2014, 04:20

... directly and via reduced glutathione (GSH), defends these cells against oxidative stress. G6PD deficiency is a prime example of an HA due to interaction between an intracorpuscular and an extracorpuscular ... G6PD activity in most tissues, this is less marked than in red cells, and it does not seem to produce symptoms. Figure 101- 4 Diagram of redox metabolism in the r...

Ngày tải lên: 07/07/2014, 04:20