Chapter 080 Cancer Cell Biology and Angiogenesis (Part 9) ppt

... cutaneous T cell lymphoma (e.g., vorinostat) and some solid tumors. HDAC inhibitors may target cancer cells via a number of mechanisms including upregulation of death receptors (DR4/5, FAS, and their ... (DR4/5, FAS, and their ligands) and p21 Cip1/Waf1 , as well as inhibition of cell cycle checkpoints. The pattern of gene transcription is aberrant in all human cancers, and...

Ngày tải lên: 07/07/2014, 01:20

... before the clinical utility of this approach can be fully realized. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3) Figure 80-1 ... other stimuli, and predisposes cells to chromosome instability. This genomic instability greatly increases the probability that p53 null cells will acquire additional mutations and become malignant. ... transcription...

Ngày tải lên: 07/07/2014, 01:20

... -C, and -D are produced by tumor cells and stromal cells in response to hypoxia or oncogenic signals, and induce production of new blood vessels and lymphatic channels through which tumor cells ... factor beta (TGF-β) and the hepatocyte growth factor (HGF)/c-Met pathways, as well as changes in the expression of adhesion molecules that mediate cell- cell and cell- extracellu...

Ngày tải lên: 07/07/2014, 01:20

... synthesis and mitosis and in response to environmental mutagens; these repair pathways are often abnormal in cancer cells. When a normal cell has sustained too much damage to repair, the cell activates ... damage to the organ. These cell death pathways are also commonly altered in cancer cells, leading to the survival of damaged cells that would normally die. Cancer cells...

Ngày tải lên: 07/07/2014, 01:20

... whether a cell will enter S-phase. The complex of CDK4 or CDK6 with D type cyclins forms a G 1 -specific kinase whose activity is regulated by growth factors, nutrients, and cell- cell and cell- matrix ... targeted therapy of cancer. Therapeutic Approaches to Cell Cycle Abnormalities in Cancer The mechanism of cell division is substantially the same in all dividing cells...

Ngày tải lên: 07/07/2014, 01:20

... melanoma, prostate, lung, breast, and colon cancer cells in vitro. Clinical trials of telomerase vaccines are underway. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) Telomerase DNA ... epithelium, and germ cells) that require extensive cell division to maintain tissue homeostasis. More than 90% of human cancers express high levels of telomerase that...

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... Breast cancer Binds HER2 on tumor cell surface and induces receptor internalization. Cetuximab (Erbitux) EGFR Colon cancer, squamous cell carcinoma of the head and neck Binds extracellular ... Possible activity against BRAF in melanoma, colon cancer, and others. Erlotinib (Tarceva) EGFR Non- small cell lung cancer; pancreatic cancer Competitive inhibit...

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... of tumor cells and induces internalization of the receptor, thereby reducing the level of surface expression. This leads to inhibition of cell cycle progression and renders cancer cells more ... breast cancer patients. The PDGFR and its ligand, platelet-derived growth factor (PDGF), are overexpressed in many glioblastomas and in subsets of melanoma, ovarian, pancreatic, ga...

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... the cancer cell, without harming normal cells (which maintain wild-type function for gene A). High- throughput screens can now be performed using isogenic cell line pairs in which one cell ... transition and passage through the cell cycle. Inhibition of one pathway (such as pathway A by a targeted inhibitor) has no significant effect due to redundancy provi ded by pathways B...

Ngày tải lên: 07/07/2014, 01:20

... that may include growth arrest, differentiation, or apoptosis. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 8) PI3K is a heterodimeric lipid kinase that catalyses the conversion ... of Myc, β-catenin, cyclin D1, and cyclin E, and blocking upregulation of p27 Kip1 and Bim (an apoptosis-inducing protein). Furthermore, the growth of cancer cells requ...

Ngày tải lên: 07/07/2014, 01:20