medical biochemistry human metabolism in health and disease

... the activity of a serine-threonine protein kinase called protein kinase A (PKA). Briefly, this particu- lar signaling pathway involves binding of glucagon or epinephrine to its respective ... tools to comprehend and appreciate the detailed resources-both print and electronic-that contain the ever-expanding body of knowledge on human metabolism in health and disease. MI...

Ngày tải lên: 06/07/2014, 15:19

... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinase domain. The mutated residues are indicated in yellow, a-helices are in cyan, ... T-cell kinase (ITK) could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry- ing a fusion protein, originating from a translo...

Ngày tải lên: 14/02/2014, 18:20

... Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechopen.com Aneuploidy in Health and Disease, Edited by ... processes are involved in maintenance and propagation of genetic information: DNA replication, DNA damage repair and chromosome segregation. Error in any of these processes migh...

Ngày tải lên: 21/02/2014, 23:20

... myofibrillar protein from tissues containing myosin and actin (muscle, smooth muscle such as gut, skin). In man, 3-methylhistidine is quantitatively excreted into urine; in rat, 3-methylhistidine is also ... Needs in Disease Most of the discussion to this point has centered around amino acid and protein metabolism in normal individuals. Although the effect of disease on ami...

Ngày tải lên: 06/03/2014, 05:21

... integrin-binding ligand N-linked glycoprotein (SIBLING) Individual members of the SIBLING family are known to bind strongly to both pro- and active forms of specific MMPs. Bone sialoprotein binds ... proMMP-binding partners involved in activation. Allosteric activation Gelatinase interactions with collagen and gelatin Binding of macromolecules or specific thiol-binding reagents to an MMP...

Ngày tải lên: 15/03/2014, 00:20

... and mRNA binding to cytosolic and poly- some proteins in brain and peripheral tissues. Brain Res. Mol. Brain Res. 58, 170–177. 39. Lauger, P. (1991) Na,K-ATPase, in Electrogenic Ion Pumps, Sinauer, ... HOMEOSTASIS AND NEUROLOGICAL DISEASE Substantial progress has been made in the understanding of the pathophysiology and mechanisms involved in the attenuation of brain homeo...

Ngày tải lên: 15/03/2014, 19:20

... modulated by lumican-evoked signaling, including vinculin and focal adhesion kinase [82]. Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe- sion ... with the EGF-binding domain [32]. The structural constraints of the EGFR binding region support a stochiometry of 1 : 1 for the decorin pro- tein core and EGFR, suggesting that...

Ngày tải lên: 15/03/2014, 23:20

... motif) that maintains them as inactive zymogens, and a catalytic domain with a z inc-binding site (Zn, HEXXHXXGXXH) and a conserved methionine (Met-turn) supporting the catalytic zinc. Interaction between ... (GAIP)-interacting C-terminus ⁄ synectin and calc ium ⁄ calmodulin-associated serine kinase, since the C2 region contains a class II PSD-95 ⁄ Discs-large ⁄ Zonula occludens protein...

Ngày tải lên: 15/03/2014, 23:20

... Accumulating evidences indicate that HSPGs act to inhibit cellular invasion by promoting tight cell–cell and cell–ECM interactions, and by main- taining the structural integrity and self-assembly ... signaling. Expression of HSulf-1 in cell lines derived from head and neck carcinoma inhibits cell growth, motility and invasion in vitro [17]. Similarly, overexpression of HSulf-1...

Ngày tải lên: 15/03/2014, 23:20