Chapter 005 Principles of Clinical Pharmacology (Part 10) doc

... Chapter 005. Principles of Clinical Pharmacology (Part 10) Multiple Variants Modulating Drug Effects As this discussion makes clear, for each drug with a defined mechanism of action ... Indeed, one major result of understanding of the role of genetics in drug action has been improved screening of drugs during the development process to reduce the likelihood...

Ngày tải lên: 06/07/2014, 08:20

... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of...

Ngày tải lên: 06/07/2014, 08:20

... effect of the drugs, it may produce severe agonist–mediated effects (such as hypertension or tachycardia) if the blocking drug is abruptly withdrawn. Chapter 005. Principles of Clinical Pharmacology ... site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceive. For drugs used i...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 12) Drug Interactions Not Mediated by Changes in Drug Disposition Drugs may act on separate components of a common process ... with combinations of antiplatelet agents (glycoprotein IIb/IIIa inhibitors, aspirin, clopidogrel) and anticoagulants (warfarin, heparins) are often used in the treatment of vascular dis...

Ngày tải lên: 06/07/2014, 08:20

... chemically alter nuclear material, stimulating the formation of antinuclear antibodies and Chapter 005. Principles of Clinical Pharmacology (Part 13) Epidemiology Patients receive, on average, ... tissue toxicity. Because of the reactive nature of these metabolites, covalent binding often occurs close to the site of production, typically the liver. The most comm...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the sa...

Ngày tải lên: 06/07/2014, 08:20

... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5- 2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its si...

Ngày tải lên: 06/07/2014, 08:20

... orally Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of ... volume of distribution of lidocaine is reduced. Therefore, lower-than- normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid t...

Ngày tải lên: 06/07/2014, 08:20

... and Response Chapter 005. Principles of Clinical Pharmacology (Part 6) Principles of Dose Selection The desired goal of therapy with any drug is to maximize the likelihood of a beneficial ... an understanding of the relationships between plasma concentration and anticipated effects. For example, measurement of QT interval is used during treatment with sotalol...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 005. Principles of Clinical Pharmacology (Part 7) Renal Disease Renal excretion of parent drug and metabolites is generally accomplished ... of lidocaine is reduced by about 50% in heart failure, and therapeutic plasma levels are achieved at infusion rates of 50% or less than those usually required. The volume of distribution of ... linked to the occurr...

Ngày tải lên: 06/07/2014, 08:20